scholarly journals Evaluation of microbubble contrast agents for dynamic imaging with x-ray phase contrast

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
T. P. Millard ◽  
M. Endrizzi ◽  
N. Everdell ◽  
L. Rigon ◽  
F. Arfelli ◽  
...  

2015 ◽  
Vol 22 (5) ◽  
pp. 1279-1288 ◽  
Author(s):  
Isobel A. Aloisio ◽  
David M. Paganin ◽  
Christopher A. Wright ◽  
Kaye S. Morgan

Phase-contrast X-ray imaging using a paper analyzer enables the visualization of X-ray transparent biological structures using the refractive properties of the sample. The technique measures the sample-induced distortions of a spatially random reference pattern to retrieve quantitative sample information. This phase-contrast method is promising for biomedical application due to both a simple experimental set-up and a capability for real-time imaging. The authors explore the experimental configuration required to achieve robustness and accuracy in terms of (i) the paper analyzer feature size, (ii) the sample-to-detector distance, and (iii) the exposure time. Results using a synchrotron source confirm that the technique achieves accurate phase retrieval with a range of paper analyzers and at exposures as short as 0.5 ms. These exposure times are sufficiently short relative to characteristic physiological timescales to enable real-time dynamic imaging of living samples. A theoretical guide to the choice of sample-to-detector distance is also derived. While the measurements are specific to the set-up, these guidelines, the example speckle images, the strategies for analysis in the presence of noise and the experimental considerations and discussion will be of value to those who wish to use the speckle-tracking paper analyzer technique.



2005 ◽  
Vol 50 (21) ◽  
pp. 5031-5040 ◽  
Author(s):  
R A Lewis ◽  
N Yagi ◽  
M J Kitchen ◽  
M J Morgan ◽  
D Paganin ◽  
...  
Keyword(s):  




2008 ◽  
Vol 53 (23) ◽  
pp. 6911-6923 ◽  
Author(s):  
Christopher M Laperle ◽  
Theron J Hamilton ◽  
Philip Wintermeyer ◽  
Evan J Walker ◽  
Daxin Shi ◽  
...  


2020 ◽  
Vol 64 (2) ◽  
pp. 20503-1-20503-5
Author(s):  
Faiz Wali ◽  
Shenghao Wang ◽  
Ji Li ◽  
Jianheng Huang ◽  
Yaohu Lei ◽  
...  

Abstract Grating-based x-ray phase-contrast imaging has the potential to enhance image quality and provide inner structure details non-destructively. In this work, using grating-based x-ray phase-contrast imaging system and employing integrating-bucket method, the quantitative expressions of signal-to-noise ratios due to photon statistics and mechanical error are analyzed in detail. Photon statistical noise and mechanical error are the main sources affecting the image noise in x-ray grating interferometry. Integrating-bucket method is a new phase extraction method translated to x-ray grating interferometry; hence, its image quality analysis would be of great importance to get high-quality phase image. The authors’ conclusions provide an alternate method to get high-quality refraction signal using grating interferometer, and hence increases applicability of grating interferometry in preclinical and clinical usage.





Author(s):  
Jianheng Huang ◽  
Yaohu Lei ◽  
Xin Liu ◽  
Jinchuan Guo ◽  
Ji Li ◽  
...  


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