scholarly journals Ethyl acetate fraction of Amomum xanthioides improves bile duct ligation-induced liver fibrosis of rat model via modulation of pro-fibrogenic cytokines

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Hyeong-Geug Kim ◽  
Jong-Min Han ◽  
Jin-Seok Lee ◽  
Jong Suk Lee ◽  
Chang-Gue Son
Keyword(s):  
Bile Duct ◽  
Liver Fibrosis ◽  
Ethyl Acetate ◽  
Rat Model ◽  
Bile Duct Ligation ◽  
Ethyl Acetate Fraction ◽  
Duct Ligation

scholarly journals Amniotic Membrane Application Reduces Liver Fibrosis in a Bile Duct Ligation Rat Model

2011 ◽  
Vol 20 (3) ◽  
pp. 441-453 ◽  
Author(s):  
Luciana B. Sant'anna ◽  
Anna Cargnoni ◽  
Lorenzo Ressel ◽  
Graziella Vanosi ◽  
Ornella Parolini
Keyword(s):  
Bile Duct ◽  
Liver Fibrosis ◽  
Amniotic Membrane ◽  
Rat Model ◽  
Bile Duct Ligation ◽  
Duct Ligation

Aqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligation

2012 ◽  
Vol 50 (10) ◽  
pp. 3505-3513 ◽  
Author(s):  
Jong-Min Han ◽  
Hyeong-Geug Kim ◽  
Min-Kyung Choi ◽  
Jin-Suk Lee ◽  
Hye-Jung Park ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Fibrosis ◽  
Aqueous Extract ◽  
Rat Model ◽  
Bile Duct Ligation ◽  
Artemisia Iwayomogi ◽  
Duct Ligation

CGX, a multiple herbal drug, improves cholestatic liver fibrosis in a bile duct ligation-induced rat model

2013 ◽  
Vol 145 (2) ◽  
pp. 653-662 ◽  
Author(s):  
Hyeong-Geug Kim ◽  
Jong-Min Han ◽  
Hye-Won Lee ◽  
Jin-Seok Lee ◽  
Seung-Wan Son ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Fibrosis ◽  
Rat Model ◽  
Bile Duct Ligation ◽  
Herbal Drug ◽  
Duct Ligation

scholarly journals 3D molecular MR imaging of liver fibrosis and response to rapamycin therapy in a bile duct ligation rat model

2015 ◽  
Vol 63 (3) ◽  
pp. 689-696 ◽  
Author(s):  
Christian T. Farrar ◽  
Danielle K. DePeralta ◽  
Helen Day ◽  
Tyson A. Rietz ◽  
Lan Wei ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Fibrosis ◽  
Mr Imaging ◽  
Rat Model ◽  
Bile Duct Ligation ◽  
Duct Ligation

Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis

2012 ◽  
Vol 32 (9) ◽  
pp. 1342-1353 ◽  
Author(s):  
Erawan Borkham-Kamphorst ◽  
Sebastian Huss ◽  
Eddy Leur ◽  
Ute Haas ◽  
Ralf Weiskirchen
Keyword(s):  
Bile Duct ◽  
Gene Transfer ◽  
Liver Fibrosis ◽  
Bile Duct Ligation ◽  
Hepatocyte Apoptosis ◽  
Duct Ligation

scholarly journals PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA

FEBS Letters ◽  
2007 ◽  
Vol 581 (16) ◽  
pp. 3098-3104 ◽  
Author(s):  
Hongtao Wang ◽  
Yan Zhang ◽  
Robert O. Heuckeroth
Keyword(s):  
Bile Duct ◽  
Liver Fibrosis ◽  
Bile Duct Ligation ◽  
Duct Ligation ◽  
Pai 1

Polyphenols from Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats

2003 ◽  
Vol 285 (5) ◽  
pp. G1004-G1013 ◽  
Author(s):  
Zhi Zhong ◽  
Matthias Froh ◽  
Mark Lehnert ◽  
Robert Schoonhoven ◽  
Liu Yang ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Fibrosis ◽  
Transforming Growth Factor ◽  
Bile Duct Ligation ◽  
Smooth Muscle Actin ◽  
Control Diet ◽  
Free Radical Scavengers ◽  
Bile Duct Proliferation ◽  
Duct Ligation ◽  
Experimental Cholestasis

Accumulation of hydrophobic bile acids during cholestasis leads to generation of oxygen free radicals in the liver. Accordingly, this study investigated whether polyphenols from green tea Camellia sinenesis, which are potent free radical scavengers, decrease hepatic injury caused by experimental cholestasis. Rats were fed a standard chow or a diet containing 0.1% polyphenolic extracts from C. sinenesis starting 3 days before bile duct ligation. After bile duct ligation, serum alanine transaminase increased to 760 U/l after 1 day in rats fed a control diet. Focal necrosis and bile duct proliferation were also observed after 1–2 days, and fibrosis developed 2–3 wk after bile duct ligation. Additionally, procollagen-α1(I) mRNA increased 30-fold 3 wk after bile duct ligation, accompanied by increased expression of α-smooth muscle actin and transforming growth factor-β and the accumulation of 4-hydroxynenonal, an end product of lipid peroxidation. Polyphenol feeding blocked or blunted all of these bile duct ligation-dependent changes by 45–73%. Together, the results indicate that cholestasis due to bile duct ligation causes liver injury by mechanisms involving oxidative stress. Polyphenols from C. sinenesis scavenge oxygen radicals and prevent activation of stellate cells, thereby minimizing liver fibrosis.

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