scholarly journals Combinatorial RNA Interference Therapy Prevents Selection of Pre-existing HBV Variants in Human Liver Chimeric Mice

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Yao-Ming Shih ◽  
Cheng-Pu Sun ◽  
Hui-Hsien Chou ◽  
Tzu-Hui Wu ◽  
Chun-Chi Chen ◽  
...  
Keyword(s):  
Rna Interference ◽  
Human Liver ◽  
Chimeric Mice ◽  
Hbv Variants ◽  
Selection Of

Efficacy of HDV mono-infection with genotype 1 and 3 in CRPISPR/Cas generated humanized NTCP mice compared to human liver chimeric mice

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
K Giersch ◽  
T Volz ◽  
J Kah ◽  
L Allweiss ◽  
A Lohse ◽  
...  
Keyword(s):  
Human Liver ◽  
Genotype 1 ◽  
Chimeric Mice

scholarly journals Efficacy of hepatitis B virus ribonuclease H inhibitors, a new class of replication antagonists, in FRG human liver chimeric mice

2018 ◽  
Vol 149 ◽  
pp. 41-47 ◽  
Author(s):  
Kelly R. Long ◽  
Elena Lomonosova ◽  
Qilan Li ◽  
Nathan L. Ponzar ◽  
Juan A. Villa ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Liver ◽  
Ribonuclease H ◽  
Chimeric Mice ◽  
New Class ◽  
B Virus

Emergence and selection of HBV variants in an anti-HBe positive patient persistently infected with quasi-species

1997 ◽  
Vol 26 (4) ◽  
pp. 748-753 ◽  
Author(s):  
Alexandra Alexopoulou ◽  
Peter Karayiannis ◽  
Stephanos J. Hadziyannis ◽  
Nobuyashu Aiba ◽  
Howard C. Thomas
Keyword(s):  
Positive Patient ◽  
Persistently Infected ◽  
Hbv Variants ◽  
Selection Of

scholarly journals Plasmodium vivax Liver Stage Development and Hypnozoite Persistence in Human Liver-Chimeric Mice

2015 ◽  
Vol 17 (4) ◽  
pp. 536 ◽  
Author(s):  
Sebastian A. Mikolajczak ◽  
Ashley M. Vaughan ◽  
Niwat Kangwanrangsan ◽  
Wanlapa Roobsoong ◽  
Matthew Fishbaugher ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Human Liver ◽  
Chimeric Mice ◽  
Liver Stage ◽  
Stage Development

scholarly journals Autofluorescence in freshly isolated adult human liver sinusoidal cells

2021 ◽  
Vol 65 (4) ◽  
Author(s):  
Anett Kristin Larsen ◽  
Jaione Simón-Santamaría ◽  
Kjetil Elvevold ◽  
Bo Göran Ericzon ◽  
Kim Erlend Mortensen ◽  
...  
Keyword(s):  
Human Liver ◽  
Cultured Cells ◽  
Confocal Imaging ◽  
Live Cells ◽  
Sinusoidal Cells ◽  
Imaging Flow Cytometry ◽  
Wide Range ◽  
Liver Sinusoidal Cells ◽  
Liver Endothelial Cells ◽  
Selection Of

Autofluorescent granules of various sizes were observed in primary human liver endothelial cells (LSECs) upon laser irradiation using a wide range of wavelengths. Autofluorescence was detected in LAMP-1 positive vesicles, suggesting lysosomal location. Confocal imaging of freshly prepared cultures and imaging flow cytometry of non-cultured cells revealed fluorescence in all channels used. Treatment with a lipofuscin autofluorescence quencher reduced autofluorescence, most efficiently in the near UV-area. These results, combined with the knowledge of the very active blood clearance function of LSECs support the notion that lysosomally located autofluorescent material reflected accumulation of lipofuscin in the intact liver. These results illustrate the importance of careful selection of fluorophores, especially when labelling of live cells where the quencher is not compatible.

scholarly journals Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

2010 ◽  
Vol 120 (3) ◽  
pp. 924-930 ◽  
Author(s):  
Karl-Dimiter Bissig ◽  
Stefan F. Wieland ◽  
Phu Tran ◽  
Masanori Isogawa ◽  
Tam T. Le ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hepatitis B ◽  
Human Liver ◽  
Chimeric Mice
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