scholarly journals Erratum: Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Chong Yew Tan ◽  
Samuel Virtue ◽  
Steven Murfitt ◽  
Lee D. Roberts ◽  
Yi Hui Phua ◽  
...  
Author(s):  
André C. Carpentier

Insulin inhibits systemic nonesterified fatty acid (NEFA) flux to a greater degree than glucose or any other metabolite. This remarkable effect is mainly due to insulin-mediated inhibition of intracellular triglyceride (TG) lipolysis in adipose tissues and is essential to prevent diabetic ketoacidosis, but also to limit the potential lipotoxic effects of NEFA in lean tissues that contributes to the development of diabetes complications. Insulin also regulates adipose tissue fatty acid esterification, glycerol and TG synthesis, lipogenesis and possibly oxidation, contributing to the trapping of dietary fatty acids in the postprandial state. Excess NEFA flux at a given insulin level has been used to define in vivo adipose tissue insulin resistance. Adipose tissue insulin resistance defined in this fashion has been associated with several dysmetabolic features and complications of diabetes, but the mechanistic significance of this concept is not fully understood. This review focusses on the in vivo regulation of adipose tissue fatty acid metabolism by insulin and the mechanistic significance of the current definition of adipose tissue insulin resistance. One hundred years after the discovery of insulin and despite decades of investigations, much is still to be understood about the multifaceted in vivo actions of this hormone on adipose tissue fatty acid metabolism.


2001 ◽  
Vol 120 (5) ◽  
pp. A710-A710
Author(s):  
S LAL ◽  
J MCLAUGHLIN ◽  
O NIAZ ◽  
G DOCKRAY ◽  
A VARRO ◽  
...  

2012 ◽  
Vol 86 (4-5) ◽  
pp. 189-199 ◽  
Author(s):  
Remko S. Kuipers ◽  
Martine F. Luxwolda ◽  
Pieter J. Offringa ◽  
E. Rudy Boersma ◽  
D.A. Janneke Dijck-Brouwer ◽  
...  

1983 ◽  
Vol 31 (12) ◽  
pp. 4213-4219 ◽  
Author(s):  
HIROSHI NAKAHARA ◽  
SATOSHI OKADA ◽  
KENSHU MOCHIDA ◽  
HIDENOBU OHMORI ◽  
MASAICHIRO MASU

Pancreatology ◽  
2020 ◽  
Vol 20 ◽  
pp. S41
Author(s):  
U. Mahajan ◽  
G. Adam ◽  
A. Alnatsha ◽  
Q. Li ◽  
G. Beyer ◽  
...  

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