460 Effect of Different Fatty Acid Profiles in the Maternal and Finishing Diet on Subcutaneous Adipose Tissue Fatty Acid Profile and Gene Expression.

This study was conducted to determine the effects of feeding oil palm frond silage based diets with added linseed oil (LO) containing highα-linolenic acid (C18:3n-3), namely, high LO (HLO), low LO (LLO), and without LO as the control group (CON) on the fatty acid (FA) composition of subcutaneous adipose tissue and the gene expression of peroxisome proliferator-activated receptor (PPAR)α, PPAR-γ, and stearoyl-CoA desaturase (SCD) in Boer goats. The proportion of C18:3n-3 in subcutaneous adipose tissue was increased (P<0.01) by increasing the LO in the diet, suggesting that the FA from HLO might have escaped ruminal biohydrogenation. Animals fed HLO diets had lower proportions of C18:1 trans-11, C18:2n-6, CLA cis-9 trans-11, and C20:4n-6 and higher proportions of C18:3n-3, C22:5n-3, and C22:6n-3 in the subcutaneous adipose tissue than animals fed the CON diets, resulting in a decreased n-6:n-3 fatty acid ratio (FAR) in the tissue. In addition, feeding the HLO diet upregulated the expression of PPAR-γ(P<0.05) but downregulated the expression of SCD (P<0.05) in the adipose tissue. The results of the present study show that LO can be safely incorporated in the diets of goats to enrich goat meat with potential health beneficial FA (i.e., n-3 FA).

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Seven Countries Study cohort in Crete, Greece: gluteal adipose-tissue fatty-acid profiles of survivors, at 2010

Public Health Nutrition ◽

10.1017/s1368980015002335 ◽

2015 ◽

Vol 19 (7) ◽

pp. 1164-1167 ◽

Cited By ~ 1

Author(s):

Christopher Papandreou ◽

Michalis Kiriakakis ◽

Georgios A Fragkiadakis ◽

Christos M Hatzis ◽

Anthony G Kafatos

Keyword(s):

Adipose Tissue ◽

Fatty Acid ◽

Rural Areas ◽

Lower Amount ◽

Study Cohort ◽

Diet Change ◽

Fatty Acid Profiles ◽

Adipose Tissue Fatty Acid ◽

Tissue Fatty Acid ◽

Seven Countries Study

AbstractObjectiveTo analyse the gluteal adipose-tissue fatty-acid profiles from Cretan cohort survivors of the Seven Countries Study (SCS) at 2010 and to compare them with those of survivors assessed in 2000, as well as with literature data on male Cretans at 1965.DesignWe analysed data concerning the gluteal adipose-tissue fatty acids (analysed by GC) from three studies.SettingThe island of Crete (rural areas and the city of Heraklion).SubjectsTwenty-two of the 2010 SCS survivors aged 90 years and over; seventy-eight men aged 80 years of the 2000 SCS survivors; and 280 men assessed in 1965.ResultsIn comparison to 1965 and 2000, the SCS survivors in 2010 had a higher amount of 18:1n-9 (P<0·05) in their gluteal adipose tissue and a lower amount of PUFA (P<0·05). On the other hand, a constant decrease in adipose-tissue 14:1n-5 and 16:1n-7 was recorded between 1965 and 2010 (P<0·001), and between 2000 and 2010 (P<0·05), while 18:2n-6 appeared to decrease between the 1965 and 2010 assessments (P<0·001).ConclusionsComparison with a 1965 representative Cretan sample and 2000 SCS survivors indicated an increased concentration of oleic acid (known for its protective role against mortality) and a decreased concentration of PUFA (known for their susceptibility to oxidation) in our surviving sample at 2010. These changes may reflect internal physiological processes due to diet change within these years and/or ageing.

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