scholarly journals Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Christiane Maria Ayo ◽  
Fábio Batista Frederico ◽  
Rubens Camargo Siqueira ◽  
Cinara de Cássia Brandão de Mattos ◽  
Mariana Previato ◽  
...  
Keyword(s):  
Hla Class I ◽  
Ocular Toxoplasmosis ◽  
Class I ◽  
Genes Encoding ◽  
Kir Receptors

scholarly journals Crosses of two independently derived transgenic mice demonstrate functional complementation of the genes encoding heavy (HLA-B27) and light (beta 2-microglobulin) chains of HLA class I antigens.

1987 ◽  
Vol 6 (6) ◽  
pp. 1673-1676 ◽  
Author(s):  
P. Krimpenfort ◽  
G. Rudenko ◽  
F. Hochstenbach ◽  
D. Guessow ◽  
A. Berns ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Hla Class I ◽  
Functional Complementation ◽  
Class I ◽  
Hla B27 ◽  
Hla Class I Antigens ◽  
Genes Encoding ◽  
Beta 2 ◽  
Beta 2 Microglobulin

The Fas:FasL lytic pathway is inhibited by HLA class I via a mechanism involving KIR receptors

2002 ◽  
Vol 63 (10) ◽  
pp. S18
Author(s):  
Zacharie Brahmi ◽  
Hui Lin Chua
Keyword(s):  
Hla Class I ◽  
Class I ◽  
Kir Receptors

Neonatal NK-cell repertoires are functionally, but not structurally, biased toward recognition of self HLA class I

Blood ◽  
2011 ◽  
Vol 117 (19) ◽  
pp. 5152-5156 ◽  
Author(s):  
Kathrin Schönberg ◽  
Johannes C. Fischer ◽  
Gesine Kögler ◽  
Markus Uhrberg
Keyword(s):  
Nk Cells ◽  
Cytokine Production ◽  
Nk Cell ◽  
Killer Cell ◽  
Human Leukocyte ◽  
Hla Class I ◽  
Class I ◽  
Structural Adaptation ◽  
Leukocyte Antigen ◽  
Kir Receptors

Abstract Human natural killer (NK)–cell repertoires are biased toward more frequent expression of inhibitory killer cell Ig-like receptor (KIR) receptors for self-human leukocyte antigen (HLA) class I. Moreover, only those NK cells that express cognate receptors for self are fully functional in terms of cytotoxicity and cytokine production. It is so far unknown whether functional education and structural adaptation to HLA class I are implemented during NK-cell development and whether both processes are mechanistically connected. Here we show that NK-cell repertoires in cord blood are not yet shaped toward increased clonal frequencies of KIR for self-HLA class I as determined for the 3 major KIR ligands C1, C2, and Bw4. Nonetheless, neonatal NK cells expressing cognate KIR exhibited enhanced effector function on the level of degranulation and cytokine production. The study suggests that functional education of cognate KIR by self-HLA class I precedes structural adaptation of KIR repertoires and that both processes are not directly linked to each other.

scholarly journals Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules

2012 ◽  
Vol 367 (1590) ◽  
pp. 800-811 ◽  
Author(s):  
Peter Parham ◽  
Paul J. Norman ◽  
Laurent Abi-Rached ◽  
Lisbeth A. Guethlein
Keyword(s):  
Mhc Class I ◽  
Nk Cell ◽  
Killer Cell ◽  
Hla Class I ◽  
Class I ◽  
Human Populations ◽  
Immune Defence ◽  
Histocompatibility Complex ◽  
Nk Cell Receptors ◽  
Genes Encoding

In placental mammals, natural killer (NK) cells are a population of lymphocytes that make unique contributions to immune defence and reproduction, functions essential for survival of individuals, populations and species. Modulating these functions are conserved and variable NK-cell receptors that recognize epitopes of major histocompatibility complex (MHC) class I molecules. In humans, for example, recognition of human leucocyte antigen (HLA)-E by the CD94:NKG2A receptor is conserved, whereas recognition of HLA-A, B and C by the killer cell immunoglobulin-like receptors (KIRs) is diversified. Competing demands of the immune and reproductive systems, and of T-cell and NK-cell immunity—combined with the segregation on different chromosomes of variable NK-cell receptors and their MHC class I ligands—drive an unusually rapid evolution that has resulted in unprecedented levels of species specificity, as first appreciated from comparison of mice and humans. Counterparts to human KIR are present only in simian primates. Observed in these species is the coevolution of KIR and the four MHC class I epitopes to which human KIR recognition is restricted. Unique to hominids is the emergence of the MHC-C locus as a supplier of specialized and superior ligands for KIR. This evolutionary trend is most highly elaborated in the chimpanzee. Unique to the human KIR locus are two groups of KIR haplotypes that are present in all human populations and subject to balancing selection. Group A KIR haplotypes resemble chimpanzee KIR haplotypes and are enriched for genes encoding KIR that bind HLA class I, whereas group B KIR haplotypes are enriched for genes encoding receptors with diminished capacity to bind HLA class I. Correlating with their balance in human populations, B haplotypes favour reproductive success, whereas A haplotypes favour successful immune defence. Evolution of the B KIR haplotypes is thus unique to the human species.

Engagement of HLA class I α1 domain induces apoptosis of activated CD45RA+ T cells

1997 ◽  
Vol 56 (1-3) ◽  
pp. 69
Author(s):  
L Genestier
Keyword(s):  
T Cells ◽  
Hla Class I ◽  
Class I
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