scholarly journals Dissociable diffusion MRI patterns of white matter microstructure and connectivity in Alzheimer’s disease spectrum

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Nhat Trung Doan ◽  
Andreas Engvig ◽  
Karin Persson ◽  
Dag Alnæs ◽  
Tobias Kaufmann ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Diffusion Mri ◽  
Disease Spectrum ◽  
White Matter Microstructure

scholarly journals In vivo microstructural heterogeneity of white matter lesions in Alzheimer’s disease using tissue compositional analysis of diffusion MRI data

2019 ◽  
Author(s):  
Remika Mito ◽  
Thijs Dhollander ◽  
Ying Xia ◽  
David Raffelt ◽  
Olivier Salvado ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Diffusion Mri ◽  
Classification Scheme ◽  
Free Water ◽  
Imaging Biomarkers ◽  
White Matter Microstructure ◽  
Periventricular Lesions

AbstractWhite matter hyperintensities (WMH) are commonly observed in elderly individuals, and are typically more prevalent in Alzheimer’s disease subjects than in healthy subjects. These lesions can be identified on fluid attenuated inversion recovery (FLAIR) MRI, on which they are hyperintense compared to their surroundings. These MRI-visible lesions appear homogeneously hyperintense despite known heterogeneity in their pathological underpinnings, and are commonly regarded as surrogate markers of small vessel disease in in vivo studies. Consequently, the extent to which these lesions contribute to Alzheimer’s disease remains unclear, likely due to the somewhat limited way in which these lesions are assessed in vivo. Diffusion MRI is sensitive to white matter microstructure, and might thus be used to investigate microstructural changes within WMH. In this study, we applied a method called single-shell 3-tissue constrained spherical deconvolution, which models white matter microstructure while also accounting for other tissue compartments, to investigate WMH in vivo. Diffusion MRI data and FLAIR images were obtained from Alzheimer’s disease (n = 48) and healthy elderly control (n = 94) subjects from the Australian Imaging, Biomarkers and Lifestyle study of ageing. WMH were automatically segmented and classified as periventricular or deep lesions from FLAIR images based on their continuity with the lateral ventricles, and the 3-tissue profile of different classes of WMH was characterised by three metrics, which together characterised the relative tissue profile in terms of the white matter-, grey matter-, and fluid-like characteristics of the diffusion signal. Our findings revealed that periventricular and deep lesion classes could be distinguished from one another, and from normal-appearing white matter based on their 3-tissue profile, with substantially higher free water content in periventricular lesions than deep. Given the higher lesion load of periventricular lesions in Alzheimer’s disease patients, the 3-tissue profile of these WMH could be interpreted as reflecting the more deleterious pathological underpinnings that are associated with disease. However, when alternatively classifying lesion sub-regions in terms of distance contours from the ventricles to account for potential heterogeneity within confluent lesions, we found that the highest fluid content was present in lesion areas most proximal to the ventricles, which were common to both Alzheimer’s disease subjects and healthy controls. We argue that whatever classification scheme is used when investigating WMH, failure to account for heterogeneity within lesions may result in classification-scheme dependent conclusions. Future studies of WMH in Alzheimer’s Disease would benefit from inclusion of microstructural information when characterising lesions.

scholarly journals White matter microstructure and cerebrospinal fluid biomarkers of Alzheimer’s disease in middle‐aged cognitively unimpaired participants (the ALFA study)

2020 ◽  
Vol 16 (S2) ◽  
Author(s):  
Greg Operto ◽  
Marta Milà‐Alomà ◽  
Marc Suárez‐Calvet ◽  
Carles Falcon ◽  
Gwen Kollmorgen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
White Matter ◽  
Middle Aged ◽  
White Matter Microstructure ◽  
Cerebrospinal Fluid Biomarkers

scholarly journals Cerebrospinal Fluid Markers of Alzheimer’s Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer’s Disease

2016 ◽  
Vol 50 (3) ◽  
pp. 873-886 ◽  
Author(s):  
Kelsey E. Melah ◽  
Sharon Yuan-Fu Lu ◽  
Siobhan M. Hoscheidt ◽  
Andrew L. Alexander ◽  
Nagesh Adluru ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Cerebrospinal Fluid ◽  
White Matter ◽  
Microglial Activation ◽  
White Matter Microstructure

P1-321: White Matter Microstructure Disruption Could Be an Early Phenomenon in The Pathophysiology of Preclinical Alzheimer's Disease: FundaciÓ ACE Healthy Brain Initiative

2016 ◽  
Vol 12 ◽  
pp. P548-P548
Author(s):  
Octavio Rodriguez-Gomez ◽  
Angela Sanabria ◽  
Alba Perez ◽  
Domingo Sanchez ◽  
Susana Ruiz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Preclinical Alzheimer’S Disease ◽  
White Matter Microstructure

scholarly journals Common Alzheimer's Disease Risk Variant Within the CLU Gene Affects White Matter Microstructure in Young Adults

2011 ◽  
Vol 31 (18) ◽  
pp. 6764-6770 ◽  
Author(s):  
M. N. Braskie ◽  
N. Jahanshad ◽  
J. L. Stein ◽  
M. Barysheva ◽  
K. L. McMahon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Young Adults ◽  
White Matter ◽  
Disease Risk ◽  
Risk Variant ◽  
White Matter Microstructure

scholarly journals Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer's disease

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Alexa Pichet Binette ◽  
Guillaume Theaud ◽  
François Rheault ◽  
Maggie Roy ◽  
D Louis Collins ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Autosomal Dominant ◽  
Mean Diffusivity ◽  
Free Water ◽  
Tau Proteins ◽  
Uncinate Fasciculus ◽  
Mutation Carriers ◽  
White Matter Microstructure

Beta-amyloid (Aβ) and tau proteins, the pathological hallmarks of Alzheimer's disease (AD), are believed to spread through connected regions of the brain. Combining diffusion imaging and positron emission tomography, we investigated associations between white matter microstructure specifically in bundles connecting regions where Aβ or tau accumulates and pathology. We focussed on free-water corrected diffusion measures in the anterior cingulum, posterior cingulum, and uncinate fasciculus in cognitively normal older adults at risk of sporadic AD and presymptomatic mutation carriers of autosomal dominant AD. In Aβ-positive or tau-positive groups, lower tissue fractional anisotropy and higher mean diffusivity related to greater Aβ and tau burden in both cohorts. Associations were found in the posterior cingulum and uncinate fasciculus in preclinical sporadic AD, and in the anterior and posterior cingulum in presymptomatic mutation carriers. These results suggest that microstructural alterations accompany pathological accumulation as early as the preclinical stage of both sporadic and autosomal dominant AD.

scholarly journals White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI

Brain ◽  
2009 ◽  
Vol 132 (9) ◽  
pp. 2579-2592 ◽  
Author(s):  
Y. Zhang ◽  
N. Schuff ◽  
A.-T. Du ◽  
H. J. Rosen ◽  
J. H. Kramer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Frontotemporal Dementia ◽  
Diffusion Mri ◽  
White Matter Damage

Difference in white matter microstructure in differential diagnosis of normal pressure hydrocephalus and Alzheimer's disease

2016 ◽  
Vol 140 ◽  
pp. 52-59 ◽  
Author(s):  
Daniel Hořínek ◽  
Irena Štěpán-Buksakowska ◽  
Nikoletta Szabó ◽  
Bradley J. Erickson ◽  
Eszter Tóth ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Differential Diagnosis ◽  
White Matter ◽  
Normal Pressure Hydrocephalus ◽  
Normal Pressure ◽  
White Matter Microstructure

scholarly journals CSF T-Tau/Aβ42 Predicts White Matter Microstructure in Healthy Adults at Risk for Alzheimer’s Disease

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e37720 ◽  
Author(s):  
Barbara B. Bendlin ◽  
Cynthia M. Carlsson ◽  
Sterling C. Johnson ◽  
Henrik Zetterberg ◽  
Kaj Blennow ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
White Matter ◽  
Healthy Adults ◽  
White Matter Microstructure ◽  
T Tau
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