The paper proposes a synergy-based myoelectric control strategy for prosthetic hands. Synergy is first reviewed in the context of hand movement, then postural synergy-based proportional and simultaneous control has been introduced to prosthetic manipulation via the principal component analysis (PCA) framework. Experiments have been comprehensively carried out on lab-developed prosthetic hand called SJU-5 to evaluate the proposed method. It is evident that the synergy driven myoelectric control achieves the targeted objectives and performs well on the SJU-5 prosthetic hand.