Chapter 10. Beyond Thermogels – Other Forms of Noncovalently Formed Polymeric Hydrogels

Soft contact lenses can improve the bioavailability and prolong the residence time of drugs and, therefore, are ideal drug carriers for ophthalmic drug delivery. Hydrogels are the leading materials of soft contact lenses because of their biocompatibility and transparent characteristic. In order to increase the amount of load drug and to control their release at the expected intervals, many strategies are developed to modify the conventional contact lens as well as the novel hydrogel contact lenses that include (i) polymeric hydrogels with controlled hydrophilic/hydrophobic copolymer ratio; (ii) hydrogels for inclusion of drugs in a colloidal structure dispersed in the contact lenses; (iii) ligand-containing hydrogels; (iv) molecularly imprinted polymeric hydrogels; (v) hydrogel with the surface containing multilayer structure for drugs loading and releasing. The advantages and disadvantages of these strategies in modifying or designing hydrogel contact lenses for extended ophthalmic drug delivery are analyzed in this paper.

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In vitro drug release studies from the polymeric hydrogels based on HEA and HPMA using 4-{(E)-[(3Z)-3-(4-(acryloyloxy)benzylidene)-2-hexylidene]methyl}phenyl acrylate as a crosslinker

Biomaterials ◽

10.1016/j.biomaterials.2004.04.023 ◽

2005 ◽

Vol 26 (10) ◽

pp. 1185-1193 ◽

Cited By ~ 37

Author(s):

A. Arun ◽

B.S.R. Reddy

Keyword(s):

Drug Release ◽

In Vitro Drug Release ◽

Release Studies ◽

Polymeric Hydrogels ◽

Methyl Phenyl

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Progress in aggregation‐induced emission‐active fluorescent polymeric hydrogels

Aggregate ◽

10.1002/agt2.37 ◽

2021 ◽

Author(s):

Wei Lu ◽

Shuxin Wei ◽

Huihui Shi ◽

Xiaoxia Le ◽

Guangqiang Yin ◽

...

Keyword(s):

Aggregation Induced Emission ◽

Polymeric Hydrogels

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Detection of protein deposition on contact lens type polymeric hydrogels by Coomassie blue R staining

Biomaterials ◽

10.1016/0142-9612(91)90033-7 ◽

1991 ◽

Vol 12 (3) ◽

pp. 267-274 ◽

Cited By ~ 8

Author(s):

M.S. Goldenberg ◽

A.C. Beekman

Keyword(s):

Contact Lens ◽

Protein Deposition ◽

Coomassie Blue ◽

Polymeric Hydrogels

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3D Printed Polymeric Hydrogels for Nerve Regeneration

Polymers ◽

10.3390/polym10091041 ◽

2018 ◽

Vol 10 (9) ◽

pp. 1041 ◽

Cited By ~ 12

Author(s):

Binoy Maiti ◽

David Díaz Díaz

Keyword(s):

Nerve Regeneration ◽

Nerve Cell ◽

Clinical Applications ◽

Cell Regeneration ◽

3D Bioprinting ◽

Ability To Regenerate ◽

3D Printed ◽

Polymeric Hydrogels ◽

Human Nervous System

The human nervous system lacks an inherent ability to regenerate its components upon damage or diseased conditions. During the last decade, this has motivated the development of a number of strategies for nerve regeneration. However, most of those approaches have not been used in clinical applications till today. For instance, although biomaterial-based scaffolds have been extensively used for nerve reparation, the lack of more customized structures have hampered their use in vivo. This highlight focuses mainly on how 3D bioprinting technology, using polymeric hydrogels as bio-inks, can be used for the development of new nerve guidance channels or devices for peripheral nerve cell regeneration. In this concise contribution, some of the most recent and representative examples are highlighted to discuss the challenges involved in various aspects of 3D bioprinting for nerve cell regeneration, specifically when using polymeric hydrogels.

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