Sticky ends in a self-assembling ABA triblock copolymer: the role of ureas in stimuli-responsive hydrogels

2019 ◽  
Vol 4 (1) ◽  
pp. 91-102 ◽  
Author(s):  
Ryan T. Shafranek ◽  
Joel D. Leger ◽  
Song Zhang ◽  
Munira Khalil ◽  
Xiaodan Gu ◽  
...  
Keyword(s):  
Self Assembly ◽  
Viscoelastic Properties ◽  
Triblock Copolymer ◽  
Thermal Response ◽  
Stimuli Responsive ◽  
Self Assembling ◽  
Polymeric Hydrogels ◽  
Aba Triblock Copolymer ◽  
Responsive Hydrogels

Directed self-assembly in polymeric hydrogels allows tunability of thermal response and viscoelastic properties.

All-or-none switching of photon upconversion in self-assembled organogel systems

2017 ◽  
Vol 196 ◽  
pp. 305-316 ◽  
Author(s):  
Pengfei Duan ◽  
Deepak Asthana ◽  
Takuya Nakashima ◽  
Tsuyoshi Kawai ◽  
Nobuhiro Yanai ◽  
...  
Keyword(s):  
Self Assembly ◽  
Room Temperature ◽  
Stimuli Responsive ◽  
Molecular Systems ◽  
Controlled Assembly ◽  
Outstanding Problem ◽  
Self Assembling ◽  
New Strategy ◽  
Donor Acceptor

Aggregation-induced photon upconversion (iPUC) based on a triplet–triplet annihilation (TTA) process is successfully developed via controlled self-assembly of donor–acceptor pairs in organogel nanoassemblies. Although segregation of donor from acceptor assemblies has been an outstanding problem in TTA-based UC and iPUC, we resolved this issue by modifying both the triplet donor and aggregation induced emission (AIE)-type acceptor with glutamate-based self-assembling moieties. These donors and acceptors co-assemble to form organogels without segregation. Interestingly, these donor–acceptor binary gels show upconversion at room temperature but the upconversion phenomena were lost upon dissolution of the gels on heating. The observed changes in TTA-UC emission were thermally reversible, reflecting the controlled assembly/disassembly of the binary molecular systems. The observed on/off ratio of UC emission was much higher than that of the aggregation-induced fluorescence of the acceptor, which highlights the important role of iPUC, i.e., multi-exciton TTA for photoluminescence switching. This work bridges iPUC and supramolecular chemistry and provides a new strategy for designing stimuli-responsive upconversion systems.

Directive Effect of Chain Length in Modulating Peptide Nano-assemblies

2020 ◽  
Vol 27 (9) ◽  
pp. 923-929
Author(s):  
Gaurav Pandey ◽  
Prem Prakash Das ◽  
Vibin Ramakrishnan
Keyword(s):  
Electron Microscopy ◽  
Amino Acids ◽  
Light Scattering ◽  
Chain Length ◽  
Self Assembly ◽  
The Self ◽  
Ionic Charge ◽  
Self Assembling ◽  
Biophysical Techniques

Background: RADA-4 (Ac-RADARADARADARADA-NH2) is the most extensively studied and marketed self-assembling peptide, forming hydrogel, used to create defined threedimensional microenvironments for cell culture applications. Objectives: In this work, we use various biophysical techniques to investigate the length dependency of RADA aggregation and assembly. Methods: We synthesized a series of RADA-N peptides, N ranging from 1 to 4, resulting in four peptides having 4, 8, 12, and 16 amino acids in their sequence. Through a combination of various biophysical methods including thioflavin T fluorescence assay, static right angle light scattering assay, Dynamic Light Scattering (DLS), electron microscopy, CD, and IR spectroscopy, we have examined the role of chain-length on the self-assembly of RADA peptide. Results: Our observations show that the aggregation of ionic, charge-complementary RADA motifcontaining peptides is length-dependent, with N less than 3 are not forming spontaneous selfassemblies. Conclusion: The six biophysical experiments discussed in this paper validate the significance of chain-length on the epitaxial growth of RADA peptide self-assembly.

Supramolecular ABA Triblock Copolymer with Polyrotaxane as B Block and Its Hierarchical Self-Assembly

2008 ◽  
Vol 41 (14) ◽  
pp. 5295-5300 ◽  
Author(s):  
Lixia Ren ◽  
Fuyou Ke ◽  
Yongming Chen ◽  
Dehai Liang ◽  
Jin Huang
Keyword(s):  
Self Assembly ◽  
Triblock Copolymer ◽  
Aba Triblock Copolymer

Main-chain PPEGMEMA-b-PBTFVPP-b-PPEGMEMA perfluorocyclobutyl aryl ether-based amphiphilic ABA triblock copolymer: synthesis and self-assembly

RSC Advances ◽  
2015 ◽  
Vol 5 (94) ◽  
pp. 77388-77398 ◽  
Author(s):  
Chun Feng ◽  
Wenqiang Yao ◽  
Guolin Lu ◽  
Yongjun Li ◽  
Xiaoyu Huang
Keyword(s):  
Self Assembly ◽  
Triblock Copolymer ◽  
Main Chain ◽  
Triblock Copolymers ◽  
Aryl Ether ◽  
Step Growth ◽  
Aba Triblock Copolymer ◽  
Transformation Strategy

A novel perfluorocyclobutyl aryl ether-based amphiphilic ABA triblock copolymers were synthesized via the site transformation strategy using sequential thermal [2π + 2π] step-growth cycloaddition polymerization and ATRP.

From multi-responsive tri- and diblock copolymers to diblock-copolymer-decorated gold nanoparticles: the effect of architecture on micellization behaviors in aqueous solutions

Soft Matter ◽  
2015 ◽  
Vol 11 (24) ◽  
pp. 4830-4839 ◽  
Author(s):  
Lichun Song ◽  
Hui Sun ◽  
Xiaolu Chen ◽  
Xia Han ◽  
Honglai Liu
Keyword(s):  
Gold Nanoparticles ◽  
Aqueous Solutions ◽  
Diblock Copolymer ◽  
Triblock Copolymer ◽  
Diblock Copolymers ◽  
Stimuli Responsive ◽  
Aba Triblock Copolymer

This work reports on the aqueous stimuli-responsive behaviors of an ABA triblock copolymer, a BAB triblock copolymer, an AB diblock copolymer and citrate-based gold nanoparticles decorated with AB diblock copolymers.

Self-assembly of a liquid crystal ABA triblock copolymer in a B-selective organic solvent

Polymer ◽  
2015 ◽  
Vol 66 ◽  
pp. 94-99 ◽  
Author(s):  
Mohammad Tariqul Islam ◽  
Mashooq Khan ◽  
Taegyu Shin ◽  
Soo-Young Park
Keyword(s):  
Liquid Crystal ◽  
Organic Solvent ◽  
Self Assembly ◽  
Triblock Copolymer ◽  
Aba Triblock Copolymer

Synthesis of a Novel Electroactive ABA Triblock Copolymer and its Spontaneous Self-Assembly in Water

2007 ◽  
Vol 28 (15) ◽  
pp. 1559-1566 ◽  
Author(s):  
Lihong Huang ◽  
Jun Hu ◽  
Le Lang ◽  
Xuesi Chen ◽  
Yen Wei ◽  
...  
Keyword(s):  
Self Assembly ◽  
Triblock Copolymer ◽  
Aba Triblock Copolymer

Stimuli responsive hydrogels derived from a renewable resource: synthesis, self-assembly in water and application in drug delivery

2015 ◽  
Vol 3 (27) ◽  
pp. 5560-5568 ◽  
Author(s):  
Krishnamoorthy Lalitha ◽  
Y. Siva Prasad ◽  
C. Uma Maheswari ◽  
Vellaisamy Sridharan ◽  
George John ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Renewable Resource ◽  
Stimuli Responsive ◽  
Composite Gel ◽  
Drug Delivery Applications ◽  
Responsive Hydrogels

We report coumarin-tris based hydrogel and curcumin encapsulated composite gel for stimuli responsive drug delivery applications.

scholarly journals Control over the fibrillization yield by varying the oligomeric nucleation propensities of self-assembling peptides

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Chun Yin Jerry Lau ◽  
Federico Fontana ◽  
Laurens D. B. Mandemaker ◽  
Dennie Wezendonk ◽  
Benjamin Vermeer ◽  
...  
Keyword(s):  
Thermodynamic Stability ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Supramolecular Assemblies ◽  
Mechanistic Studies ◽  
Molecular Changes ◽  
Self Assembling ◽  
Charged Residues ◽  
Β Sheet

AbstractSelf-assembling peptides are an exemplary class of supramolecular biomaterials of broad biomedical utility. Mechanistic studies on the peptide self-assembly demonstrated the importance of the oligomeric intermediates towards the properties of the supramolecular biomaterials being formed. In this study, we demonstrate how the overall yield of the supramolecular assemblies are moderated through subtle molecular changes in the peptide monomers. This strategy is exemplified with a set of surfactant-like peptides (SLPs) with different β-sheet propensities and charged residues flanking the aggregation domains. By integrating different techniques, we show that these molecular changes can alter both the nucleation propensity of the oligomeric intermediates and the thermodynamic stability of the fibril structures. We demonstrate that the amount of assembled nanofibers are critically defined by the oligomeric nucleation propensities. Our findings offer guidance on designing self-assembling peptides for different biomedical applications, as well as insights into the role of protein gatekeeper sequences in preventing amyloidosis.

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