Enzyme-mediated fast injectable hydrogels based on chitosan–glycolic acid/tyrosine: preparation, characterization, and chondrocyte culture

2014 ◽  
Vol 5 (2) ◽  
pp. 391-398 ◽  
Author(s):  
Rong Jin ◽  
Chao Lin ◽  
Aoneng Cao
Keyword(s):  
Glycolic Acid ◽  
Injectable Hydrogels ◽  
Chondrocyte Culture

Effect of Poly (Lactic–Co–Glycolic Acid) (75:25)/ Hydroxyapatite Composite on Chondrocyte Culture for Tissue Reconstruction

2007 ◽  
pp. 353-356
Author(s):  
Jung Bok Lee ◽  
Seong Mi Yu ◽  
Sang Gil Lee ◽  
Jae Bong Choi ◽  
Jeong Koo Kim
Keyword(s):  
Glycolic Acid ◽  
Chondrocyte Culture ◽  
Hydroxyapatite Composite ◽  
Tissue Reconstruction

Poly(ethylene glycol)–poly(lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications

2013 ◽  
Vol 172 (3) ◽  
pp. 715-729 ◽  
Author(s):  
Amit Alexander ◽  
Ajazuddin ◽  
Junaid Khan ◽  
Swarnlata Saraf ◽  
Shailendra Saraf
Keyword(s):  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Glycolic Acid ◽  
Poly Ethylene Glycol ◽  
Injectable Hydrogels ◽  
Poly Ethylene

Preparation of glycolic acid ethyl cellulose microspheres

2013 ◽  
Vol 32 (5) ◽  
pp. 532-535
Author(s):  
Xin-xia WANG ◽  
Ya-ling LIN ◽  
Guo-qing ZHANG ◽  
Gui-chen ZHOU ◽  
Ying LU ◽  
...  
Keyword(s):  
Ethyl Cellulose ◽  
Glycolic Acid

Hepatic arterial embolization with glycolic acid-ethylcellulose microspheres in treatment of hepatic tumor in rabbits

2013 ◽  
Vol 32 (9) ◽  
pp. 954-958
Author(s):  
Dong-juan XING ◽  
Wei-hua SONG ◽  
Shao-juan GONG ◽  
Ai-min XU ◽  
Xiao-wei LI ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Arterial Embolization ◽  
Hepatic Tumor ◽  
Hepatic Arterial Embolization

5-Fluorouracil Loaded Orally Administered WGA-decorated Poly(lactic-co-glycolic acid) Nanoparticles for Treatment of Colorectal Cancer: In Vivo Evaluation

2020 ◽  
Vol 10 ◽  
Author(s):  
Aditya Nath Pandey ◽  
Kuldeep Rajpoot ◽  
Sunil K. Jain
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Oral Delivery ◽  
Wheat Germ ◽  
Glycolic Acid ◽  
Organ Distribution ◽  
In Vivo Evaluation ◽  
Distribution Study ◽  
Prolonged Retention

Background:: Several studies have suggested potential aptitude of polylactic-co-glycolic acid (PLGA)-derived nanoparticles (NPs) to improve the antitumor efficacy of anticancer drugs against colon cancer. Further, conjugation of lectins over the surface of the NPs may ameliorate interaction and thus enhance attachment of NPs with receptors. Objective:: The main goal of the study was to prepare and evaluate targeting potential (in vivo) of the optimized NPs against colorectal cancer. Methods:: The 5-fluorouracil (5-FU) loaded and wheat germ agglutinin (WGA)-conjugated PLGA-NPs (WFUNPs) were prepared and then they were evaluated in vivo for targeting aptitude of formulation using gamma scintigraphy after oral delivery. The WGA-conjugated and non-conjugated optimized NPs were compared for any significant results. Further, optimized formulations were also assessed for different parameters such as radiolabeling efficiency, sodium pertechnetate uptake, stability of NPs, and organ distribution study. Results:: Findings suggested prolonged retention of 99mTc-tagged WFUNPs in the colonic region after 24 h study. Eventually, the outcome from conjugated formulation revealed enhanced bioavailability of the drug in blood plasma for up to 24 h. Conclusion:: In conclusion, WGA-conjugation to NPs could improve the performance of the PLGA-NPs in the treatment of colorectal cancer.

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