Effectiveness, Safety, and Cost Efficacy of Water (H2O) as a Substitute for Sodium Bicarbonate (NaHCO3) Plus Solution in Neutralization of Chemical Peeling Using 35% Glycolic Acid Solution

Author(s):  
2021 ◽  
pp. 014556132098606
Author(s):  
Nguyen Quynh Anh ◽  
Pawin Numthavaj ◽  
Thongchai Bhongmakapat

Objectives: This study compared the cerumen dissolution activities of 7.5% sodium bicarbonate, 5% potassium hydroxide, 10% lactic acid, 3% salicylic acid, 10% glycolic acid, and distilled water. Methods: An in vitro study was conducted with 36 cerumen samples. The cerumenolytic activities of the 6 agents were assessed by recording the degree of cerumen disintegration using digital photography at 15 minutes, 30 minutes, 1 hour, 2 hours, and 12 hours. The undissolved cerumen that remained after 12 hours was removed from the solutions and weighed after drying. Results: Potassium hydroxide showed the fastest cerumenolytic activity, dissolving a moderate amount of cerumen at 30 minutes, while glycolic acid and salicylic acid caused no visible changes in the cerumen samples. Samples treated with potassium hydroxide and sodium bicarbonate exhibited higher degrees of disintegration compared to samples treated with distilled water (odds ratio and 95% CI: 273.237 [0.203-367 470.4] and 1.129 [0.002-850.341], respectively). The greatest reduction in cerumen weight was associated with the use of sodium bicarbonate; however, this result did not reach statistical significance. Conclusions: Among the solutions tested, 5% potassium hydroxide showed the fastest dissolution activity, yielding moderate disintegration within only 30 minutes. In terms of residual cerumen weight within 12 hours, all solutions exhibited equivalent effectiveness in the disintegration of cerumen.


Author(s):  
Jasleen Kaur ◽  
Tanreet Kaur

<p class="abstract"><strong>Background:</strong> Although various treatment options are available for the management of melasma, still it is challenging disorder to treat. Apart from topical therapies, newer modalities like laser toning and chemical peeling are being explored to manage this notorious dermatosis. To evaluate and compare the efficacy and side effects of laser toning versus 50% glycolic acid peel in the management of melasma.</p><p class="abstract"><strong>Methods:</strong> A split face comparative study was done in 30 female patients with melasma. Over the right half of patient’s face laser toning was done whereas other half was treated with 50% glycolic acid peel. 4 such sessions were given at an interval of 15 days. Response to treatment was assessed using melasma area and severity index (MASI) score.<strong></strong></p><p class="abstract"><strong>Results:</strong> Baseline mean MASI score on right and left half of patient’s face was 7.85±3.34 and 6.25±1.56 respectively. After completion of 4 treatment sessions, it was reduced to 4.23±1.45 and 3.71±1.10 respectively with statistically insignificant difference between two halves (p=0.08). Recurrence rate of melasma was higher (46.66%) with laser toning in comparison to glycolic acid peel (26.6% patients).</p><p class="abstract"><strong>Conclusions:</strong> Glycolic acid peel and laser toning were comparable in terms of outcome with laser toning showing slightly better results. In comparison to peels recurrence rate and complications like hypopigmentation in Asian patients were higher with laser toning.</p>


2017 ◽  
Vol 17 (5) ◽  
pp. 797-801
Author(s):  
Jeong In Jae ◽  
Hyun Dong Ju ◽  
Kim Dong Hyun ◽  
Moon Soo Yoon ◽  
Hee Jung Lee

2011 ◽  
Vol 17 (4) ◽  
pp. 427-433 ◽  
Author(s):  
Natsuko Kakudo ◽  
Satoshi Kushida ◽  
Nobuko Tanaka ◽  
Tatsuya Minakata ◽  
Kenji Suzuki ◽  
...  

2012 ◽  
Vol 5 (2) ◽  
pp. 122
Author(s):  
SupriyaP Deshmukh ◽  
YugalK Sharma ◽  
KirtiS Deo ◽  
NitinC Chaudhari ◽  
Kedarnath Dash

Author(s):  
Ghazal Ahmed ◽  
Dharmendra Kumar Mishra

<p class="abstract"><strong>Background:</strong> Periorbital melanosis (POM) is a common aesthetic condition with significant impact. Chemical peeling is a frequently used treatment; yet, an ideal peeling agent is however to find. The aim of the study was to compare the clinical efficacy and safety of 20% glycolic acid (GA) and 30% lactic acid (LA) peels in POM.</p><p class="abstract"><strong>Methods:</strong> With approval and consent, the study was conducted from September 2016-August 2017. Patients aged 18-60 years of both sexes, having a constitutional POM were enrolled. Patients known to be allergic to the peeling agents were excluded. Alternate patients were enrolled into Gr-G (20% GA) and Gr-L (30% LA) and were treated every 3 weeks, for 3 sessions and evaluated till 9 weeks. Clinical improvement using POM grading, patients’ global assessment, satisfaction, and physician's global satisfaction were noted. Data are presented in number, percentages and mean±standard deviation. INSTAT software was used for statistical analysis; p&lt;0.05 was considered significant.<strong></strong></p><p class="abstract"><strong>Results:</strong> Fifty-six (27 in Gr-G, 29 in Gr-L) were enrolled; 70.37% and 68.97% completed the study. Demographic variables, baseline POM grade, and skin types were similar. Compared to baseline, both Gr-G and Gr-L showed significant improvement (p&lt;0.0001). Patient-reported significantly higher improvement in Gr-L (p=0.008) and higher satisfaction. Both the peeling agents were tolerated well with statistically indifferent adverse effects.</p><strong>Conclusions:</strong>Both GA and LA are useful in the aesthetic treatment of the constitutional type of POM. Three sessions of 30% LA peel appears to be better than 20% GA peeling used at 3 weeks apart. <p> </p>


2019 ◽  
Vol 21 (27) ◽  
pp. 14941-14944 ◽  
Author(s):  
Arunas Jagminas ◽  
Giedrė Grincienė ◽  
Algis Selskis ◽  
Katsiaryna Chernyakova

This study highlighted the formation mechanism of a nanoporous alumina/graphene composite film observed by Al anodization in glycolic acid solution under extremely high current densities.


Sign in / Sign up

Export Citation Format

Share Document