The FUor Star V2493 Cyg (HBC 722)—Eleven Years at Maximum Brightness

At the time of stellar evolution, young stellar objects go through processes of increased activity and instability. Star formation takes place in several stages during which the star accumulates enough mass to initiate thermonuclear reactions in the nucleus. A significant percentage of the mass of Sun-like stars accumulates during periods of increased accretion known as FUor outbursts. Since we know only about two dozen stars of this type, the study of each new object is very important for our knowledge. In this paper, we present data from photometric monitoring on a FUor object V2493 Cyg discovered in 2010. Our data were obtained in the optical region with BVRI Johnson–Cousins set of filters during the period from November 2016 to February 2021. The results of our observations show that during this period no significant changes in the brightness of the star were registered. We only detect variations with a small amplitude around the maximum brightness value. Thus, since 2013 V2493 Cyg remains at its maximum brightness, without a decrease in brightness. Such photometric behavior is not typical of other stars from FUor type. Usually, the light curves of FUors are asymmetrical, with a very rapid rise and gradual decline of the brightness. V2493 Cyg remains unique in this respect with a very rapid rise in brightness and prolonged retention in maximum light. Our period analysis made for the interval February 2013–February 2021 reveals a well-defined period of 914 ± 10 days. Such periodicity can be explained by dust structures remaining from star formation in orbit around the star.

Intra-Articular Drug Delivery for Osteoarthritis Treatment

Osteoarthritis (OA) is the most prevalent degenerative joint disease affecting millions of people worldwide. Currently, clinical nonsurgical treatments of OA are only limited to pain relief, anti-inflammation, and viscosupplementation. Developing disease-modifying OA drugs (DMOADs) is highly demanded for the efficient treatment of OA. As OA is a local disease, intra-articular (IA) injection directly delivers drugs to synovial joints, resulting in high-concentration drugs in the joint and reduced side effects, accompanied with traditional oral or topical administrations. However, the injected drugs are rapidly cleaved. By properly designing the drug delivery systems, prolonged retention time and targeting could be obtained. In this review, we summarize the drugs investigated for OA treatment and recent advances in the IA drug delivery systems, including micro- and nano-particles, liposomes, and hydrogels, hoping to provide some information for designing the IA injected formulations.

Colonic Delivery of Celastrol-Loaded Layer-by-Layer Liposomes with Pectin/Trimethylated Chitosan Coating to Enhance Its Anti-Ulcerative Colitis Effects

Herein, a flexible oral colon-targeting delivery system, mediated by electrostatic layer-by-layer alternate deposition with pectin-trimethyl chitosan (TMC) onto liposomes-loading celastrol (Cel/PT-LbL Lipo), was fabricated to enhance anti-UC efficacy. Along with layer-by-layer coating, Cel/Lipo exhibited surface charge reversal, a slight increase in particle size, and a sustained drug release profile in a simulative gastrointestinal tract medium. Based on its bilayer coating of polysaccharides, Cel/PT-LbL Lipo alleviated cytotoxicity of celastrol in colon epithelial NCM460 cells. Due to the strong mucoadhesion of TMC with mucin, PT-LbL Lipo benefited colon localization and prolonged retention ability of its payloads. Ultimately, Cel/PT-LbL Lipo significantly mitigated colitis symptoms and accelerated colitis repair in DSS-treated mice by regulating the levels of pro-inflammatory factors related to the TLR4/MyD88/NF-κB signaling pathway. Collectively, this study demonstrates that the pectin/trimethylated chitosan coating may allow for Cel/PT-LbL Lipo to function as a more beneficial therapeutic strategy for UC treatment.

Remembering the pattern: A longitudinal case study on statistical learning in spatial navigation and memory consolidation

Distinct brain systems are thought to support statistical learning over different timescales. Regularities encountered during online perceptual experience can be acquired rapidly by the hippocampus. Further processing during offline consolidation can establish these regularities gradually in cortical regions, including the medial prefrontal cortex (mPFC). These mechanisms of statistical learning may be critical during spatial navigation, for which knowledge of the structure of an environment can facilitate future behavior. Rapid acquisition and prolonged retention of regularities have been investigated in isolation, but how they interact in the context of spatial navigation is unknown. We had the rare opportunity to study the brain systems underlying both rapid and gradual timescales of statistical learning using intracranial electroencephalography (iEEG) longitudinally in the same patient over a period of three weeks. As hypothesized, spatial patterns were represented in the hippocampus but not mPFC for up to one week after statistical learning and then represented in the mPFC but not hippocampus two and three weeks after statistical learning. Taken together, these findings clarify that the hippocampus may do the initial work of extracting regularities and transfer these integrated memories to cortex, rather than only storing individual experiences and leaving it up to cortex to extract regularities.

On Social Contagion in Gamification

Social connections shape our behaviour because of peer pressure and social contagion. This phenomenon is amplified in online networks by particularly influential individuals: influencers. Although this concept originated in social media, recent research shows how influencers can also exist in games and affect players' long-term retention. Prolonged retention caused by influencers could benefit gameful systems, especially if the system's goal is positive behavioural change. Retention is desirable because it can aid in internalizing new habits. Therefore, we investigated retention influencers' presence within a location-based persuasive gamified system (Play&Go) and their influence on other behaviours (i.e., the pursuit of a gamification goal), via social network analysis techniques. Results show how retention influencers exist in Play&Go and how studying different influence types (which push the systems' goals) may lead to different influencer groups. Our findings emphasize the importance of social mechanics in location-based gamification and discuss the value of understanding a player community to improve game design.

NIR responsive tumor vaccine in situ for photothermal ablation and chemotherapy to trigger robust antitumor immune responses

Background Therapeutic tumor vaccine (TTV) that induces tumor-specific immunity has enormous potentials in tumor treatment, but high heterogeneity and poor immunogenicity of tumor seriously impair its clinical efficacy. Herein, a novel NIR responsive tumor vaccine in situ (HA-PDA@IQ/DOX HG) was prepared by integrating hyaluronic acid functionalized polydopamine nanoparticles (HA-PDA NPs) with immune adjuvants (Imiquimod, IQ) and doxorubicin (DOX) into thermal-sensitive hydrogel. Results HA-PDA@IQ NPs with high photothermal conversion efficiency (41.2%) and T1-relaxation efficiency were using HA as stabilizer by the one-pot oxidative polymerization. Then, HA-PDA@IQ loaded DOX via π-π stacking and mixed with thermal-sensitive hydrogel to form the HA-PDA@IQ/DOX HG. The hydrogel-confined delivery mode endowed HA-PDA@IQ/DOX NPs with multiple photothermal ablation performance once injection upon NIR irradiation due to the prolonged retention in tumor site. More importantly, this mode enabled HA-PDA@IQ/DOX NPs to promote the DC maturation, memory T cells in lymphatic node as well as cytotoxic T lymphocytes in spleen. Conclusion Taken together, the HA-PDA@IQ/DOX HG could be served as a theranostic tumor vaccine for complete photothermal ablation to trigger robust antitumor immune responses.

Adenomatoid odontogenic tumor: Case report

The adenomatoid odontogenic tumor is a benign epithelial pathology that comprises 3 to 7% of odontogenic tumors. It has the characteristic of slow and progressive growth and almost no symptoms, being more frequent in women especially in the first two decades of life. Also, the anterior region of the maxilla is the anatomical location mostly affected. A white female patient, 16 years old, presented absence of the canine, first, and second maxillary premolars on the right side, prolonged retention of the right upper deciduous second molar, volumetric increase in the buccal and palatal alveolar ridge with extension to the bottom of the right maxillary vestibule, being diagnosed after the incisional biopsy as an adenomatoid odontogenic tumor. Considering the clinical and radiographic examination, it was decided to perform decompression of the lesion before performing enucleation and curettage.