Constructing a FRET-based molecular chemodosimeter for cysteine over homocysteine and glutathione by naphthalimide and phenazine derivatives

The Analyst ◽  
2015 ◽  
Vol 140 (1) ◽  
pp. 182-189 ◽  
Author(s):  
Lin Yang ◽  
Weisong Qu ◽  
Xiao Zhang ◽  
Yandi Hang ◽  
Jianli Hua
Keyword(s):  
Hela Cells ◽  
Fluorescence Enhancement ◽  
Turn On

A chemodosimeter PHSN achieved turn-on fluorescence enhancement at 540 nm and discrimination of cysteine from homocysteine and glutathione in Hela cells.

scholarly journals A 7-Hydroxybenzoxazinone-Containing Fluorescence Turn-On Probe for Biothiols and Its Bioimaging Applications

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3102 ◽  
Author(s):  
Bin Li ◽  
Datong Zhang ◽  
Ruibing An ◽  
Yaling Zhu
Keyword(s):  
Amino Acids ◽  
Detection Limit ◽  
High Resistance ◽  
Hela Cells ◽  
Fluorescence Enhancement ◽  
Stokes Shift ◽  
Potential Utility ◽  
Strong Fluorescence ◽  
Turn On ◽  
Fluorescence Turn On

In this work, a novel 7-hydroxybenzoxazinone-based fluorescent probe (PBD) for the selective sensing of biothiols is reported. Upon treatment with biothiols, PBD shows a strong fluorescence enhancement (up to 70-fold) and a large Stokes shift (155 nm). Meanwhile, this probe exhibits high resistance to interference from other amino acids and competing species. PBD features good linearity ranges with a low detection limit of 14.5 nM for glutathione (GSH), 17.5 nM for cysteine (Cys), and 80.0 nM for homocysteine (Hcy), respectively. Finally, the potential utility of this probe for biothiol sensing in living HeLa cells is demonstrated.

scholarly journals Coplanarity driven fluorescence turn-on sensor for chromium(iii) and its application for bio-imaging

2018 ◽  
Vol 17 (2) ◽  
pp. 239-244 ◽  
Author(s):  
G. Balamurugan ◽  
S. Velmathi
Keyword(s):  
Hela Cells ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Fluorescence Enhancement ◽  
Live Cell ◽  
Turn On ◽  
Bio Imaging ◽  
Heteroaromatic Aldehyde ◽  
Fluorescence Turn On

The sensing behaviour of benzimidazole and thiozole derivatives from heteroaromatic aldehyde was studied towards various cations and anions. S1 showed selectivity towards Cr3+ with fluorescence enhancement and live cell imaging of Hela cells was successfully demonstrated.

scholarly journals A Novel Thiophene-Based Fluorescent Chemosensor for the Detection of Zn2+ and CN−: Imaging Applications in Live Cells and Zebrafish

Sensors ◽  
2019 ◽  
Vol 19 (24) ◽  
pp. 5458 ◽  
Author(s):  
Min Seon Kim ◽  
Dongju Yun ◽  
Ju Byeong Chae ◽  
Haeri So ◽  
Hyojin Lee ◽  
...  
Keyword(s):  
Hela Cells ◽  
Fluorescence Enhancement ◽  
Limit Of Detection ◽  
Zinc Ion ◽  
World Health ◽  
Live Cells ◽  
Real Samples ◽  
Turn On ◽  
Health Organization ◽  
Nmr Titrations

A novel fluorescent turn-on chemosensor DHADC ((E)-3-((4-(diethylamino)-2-hydroxybenzylidene)amino)-2,3-dihydrothiophene-2-carboxamide) has been developed and used to detect Zn2+ and CN−. Compound DHADC displayed a notable fluorescence increase with Zn2+. The limit of detection (2.55 ± 0.05 μM) for zinc ion was far below the standard (76 μM) of the WHO (World Health Organization). In particular, compound DHADC could be applied to determine Zn2+ in real samples, and to image Zn2+ in both HeLa cells and zebrafish. Additionally, DHADC could detect CN− through a fluorescence enhancement with little inhibition with the existence of other types of anions. The detection processes of compound DHADC for Zn2+ and CN− were demonstrated with various analytical methods like Job plots, 1H NMR titrations, and ESI-Mass analyses.

A novel ratiometric and turn-on fluorescent coumarin-based probe for Fe(iii)

2019 ◽  
Vol 43 (30) ◽  
pp. 12032-12041 ◽  
Author(s):  
Tiziana Pivetta ◽  
Sebastiano Masuri ◽  
Maria Grazia Cabiddu ◽  
Claudia Caltagirone ◽  
Anna Pintus ◽  
...  
Keyword(s):  
Fluorescence Enhancement ◽  
Fluorescent Chemosensor ◽  
Turn On

6-Methoxy-3-(pyridin-2-yl)-2H-chromen-2-one exhibited fluorescence enhancement in the presence of Fe(iii). This molecule was a selective fluorescent chemosensor for Fe(iii).

A fluorescent turn-on probe for cyanide anion detection based on an AIE active cobalt(ii) complex

2018 ◽  
Vol 47 (6) ◽  
pp. 2079-2085 ◽  
Author(s):  
Moustafa T. Gabr ◽  
F. Christopher Pigge
Keyword(s):  
Aqueous Solution ◽  
Fluorescence Enhancement ◽  
Anion Detection ◽  
Cyanide Anion ◽  
Turn On

A Co(ii) complex based on an AIE-active tetraarylethylene ligand displays selective fluorescence enhancement in the presence of cyanide anion in aqueous solution.

A novel turn-on fluorescent probe for selective sensing and imaging of glutathione in live cells and organisms

The Analyst ◽  
2019 ◽  
Vol 144 (10) ◽  
pp. 3260-3266 ◽  
Author(s):  
Xiaodong Zhang ◽  
Ziqian Wang ◽  
Zongwei Guo ◽  
Nianzhe He ◽  
Peng Liu ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Hela Cells ◽  
K562 Cells ◽  
Live Cells ◽  
Zebrafish Embryos ◽  
Turn On ◽  
Imatinib Resistant

A novel 1-oxo-1H-phenalene-2,3-dicarbonitrile (OPD)-based fluorescent probe was developed to sense and image GSH in HeLa cells, different imatinib-resistant K562 cells, D. magna and zebrafish embryos.

A novel chemosensor with visible light excitability for sensing Zn2+in physiological medium and in HeLa cells

2014 ◽  
Vol 12 (27) ◽  
pp. 4975-4982 ◽  
Author(s):  
Barun Kumar Datta ◽  
Durairaj Thiyagarajan ◽  
Soham Samanta ◽  
Aiyagari Ramesh ◽  
Gopal Das
Keyword(s):  
Visible Light ◽  
Hela Cells ◽  
Turn On ◽  
Physiological Medium ◽  
Highly Sensitive

A highly sensitive, fluorescent, non-cytotoxic turn-on chemosensor with visible light excitability for the detection of intracellular Zn2+ions.

Two novel “turn on” fluorescent probes for monitoring hypochlorite in living HeLa cells

2021 ◽  
Vol 196 ◽  
pp. 109749
Author(s):  
Ling Wang ◽  
Rui Zhang ◽  
Ying-Cui Bu ◽  
Ze Huang ◽  
Lin Kong ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Hela Cells ◽  
Turn On

A turn-on fluorescent probe for tumor hypoxia imaging in living cells

2015 ◽  
Vol 51 (79) ◽  
pp. 14739-14741 ◽  
Author(s):  
Qi Cai ◽  
Tao Yu ◽  
Weiping Zhu ◽  
Yufang Xu ◽  
Xuhong Qian
Keyword(s):  
Fluorescent Probe ◽  
Hela Cells ◽  
Tumor Hypoxia ◽  
Living Cells ◽  
Hypoxia Imaging ◽  
Turn On ◽  
Reducing Ability ◽  
Oxygen Concentrations

A turn-on fluorescent probe was designed and synthesized for tumor hypoxia imaging, which could show excellent reducing ability under chemical or bio-reductase conditions and good performance in hypoxia imaging for HeLa cells at different oxygen concentrations.

A highly selective turn-on fluorescent sensor for fluoride and its application in imaging of living cells

2014 ◽  
Vol 38 (12) ◽  
pp. 6198-6204 ◽  
Author(s):  
Jiun-Ting Yeh ◽  
Parthiban Venkatesan ◽  
Shu-Pao Wu
Keyword(s):  
Fluorescent Probe ◽  
Fluorescence Enhancement ◽  
Fluorescent Sensor ◽  
Living Cells ◽  
Green Fluorescence ◽  
Turn On ◽  
Highly Sensitive

A highly sensitive and selective fluorescent probe (FS) is based on a fluoride-specific desilylation reaction to yield a significant green fluorescence enhancement.

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