Spiro scaffolds are being increasingly utilized in drug discovery due to their inherent three-dimensionality and structural variations, resulting in new synthetic routes to introduce spiro building blocks into more pharmaceutically active molecules. Multicomponent cascade reactions, involving thein situgeneration of carbonyl ylides from α-diazocarbonyl compounds and aldehydes, and 1,3-dipolar cycloadditon with 3-arylideneoxindoles gave a novel class of dispirooxindole derivatives, namely 1,1′′-dibenzyl-5′-(4-chlorophenyl)-4′-phenyl-4′,5′-dihydrodispiro[indoline-3,2′-furan-3′,3′′-indoline]-2,2′′-dione, C44H33ClN2O3, (I), 1′′-acetyl-1-benzyl-5′-(4-chlorophenyl)-4′-phenyl-4′,5′-dihydrodispiro[indoline-3,2′-furan-3′,3′′-indoline]-2,2′′-dione, C39H29ClN2O4, (II), 1′′-acetyl-1-benzyl-4′,5′-diphenyl-4′,5′-dihydrodispiro[indoline-3,2′-furan-3′,3′′-indoline]-2,2′′-dione, C39H30N2O4, (III), and 1′′-acetyl-1-benzyl-4′,5′-diphenyl-4′,5′-dihydrodispiro[indoline-3,2′-furan-3′,3′′-indoline]-2,2′′-dione acetonitrile hemisolvate, C39H30N2O4·0.5C2H3N, (IV). All four compounds exist as racemic mixtures of theSSSRandRRRSstereoisomers. In these structures, the two H atoms of the dihydrofuran ring and the two substituted oxindole rings are in atransorientation, facilitating intramolecular C—H...O and π–π interactions. These weak interactions play a prominent role in the structural stability and aid the highly regio- and diastereoselective synthesis. In each of the four structures, the molecular assembly in the crystal is also governed by weak noncovalent interactions. Compound (IV) is the solvated analogue of (III) and the two compounds show similar structural features.
Cu3Pt1–Cu2O nanocomposites: synergistic effect-dependent high activity and stability for the gas-phase selective oxidation of alcohols