Characterization of tumor-targeting Ag2S quantum dots for cancer imaging and therapy in vivo

Nanoscale ◽  
2014 ◽  
Vol 6 (21) ◽  
pp. 12580-12590 ◽  
Author(s):  
Haiyan Chen ◽  
Bowen Li ◽  
Min Zhang ◽  
Kang Sun ◽  
Yiran Wang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Tumor Targeting ◽  
Cancer Imaging ◽  
Ag2s Quantum Dots

Aqueous synthesis of PEGylated Ag2S quantum dots and their in vivo tumor targeting behavior

2020 ◽  
Vol 529 (4) ◽  
pp. 930-935
Author(s):  
Feng Lu ◽  
Wenwen Ju ◽  
Ning Zhao ◽  
Ting Zhao ◽  
Chen Zhan ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Tumor Targeting ◽  
Aqueous Synthesis ◽  
Ag2s Quantum Dots

In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near-Infrared Region

2012 ◽  
Vol 51 (39) ◽  
pp. 9818-9821 ◽  
Author(s):  
Guosong Hong ◽  
Joshua T. Robinson ◽  
Yejun Zhang ◽  
Shuo Diao ◽  
Alexander L. Antaris ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Infrared Region ◽  
In Vivo Fluorescence ◽  
In Vivo Fluorescence Imaging ◽  
Near Infrared Region ◽  
Ag2s Quantum Dots

Use of the Semiconductor Nanotechnologies “Quantum Dots” for in vivo Cancer Imaging

2009 ◽  
Vol 4 (3) ◽  
pp. 207-215 ◽  
Author(s):  
Monica Ciarlo ◽  
Patrizia Russo ◽  
Alfredo Cesario ◽  
Sara Ramella ◽  
Gabriella Baio ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Cancer Imaging

scholarly journals Sortase-mediated site-specific modification of interleukin-2 for the generation of a tumor targeting acetazolamide-cytokine conjugate

2020 ◽  
Author(s):  
Baptiste Gouyou ◽  
J Millul ◽  
A Villa ◽  
S Cazzamalli ◽  
D Neri ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Tumor Targeting ◽  
Interleukin 2 ◽  
Industrial Applications ◽  
Carbonic Anhydrase Ix ◽  
Site Specific ◽  
Tumor Bearing ◽  
Bioactive Proteins

1.AbstractSmall ligands specific to tumor-associated antigens can be used as alternatives to antibodies for the delivery of small payloads such as radionuclides, cytotoxic drugs and fluorophores. Their use as delivery moiety of bioactive proteins like cytokines remains largely unexplored. Here, we describe the preparation and in vivo characterization of the first small molecule-cytokine conjugate targeting carbonic anhydrase IX (CAIX), a marker of renal cell carcinoma and hypoxia. Site-specific conjugation between interleukin-2 and acetazolamide was obtained by Sortase A-mediated transpeptidation. Binding of the conjugate to the cognate CAIX antigen was confirmed by surface plasmon resonance. The in vivo targeting of structures expressing carbonic anhydrase IX was assessed by biodistribution experiments in tumor bearing mice. Optimization of manufacturability and tumor targeting performance of acetazolamide-cytokine products will be required in order to enable industrial applications.Graphical abstract

Radioisotope Co-57 incorporated layered double hydroxide nanoparticles as a cancer imaging agent

RSC Advances ◽  
2016 ◽  
Vol 6 (54) ◽  
pp. 48415-48419 ◽  
Author(s):  
Tae-Hyun Kim ◽  
Jun Young Lee ◽  
Min-Kyu Kim ◽  
Jeong Hoon Park ◽  
Jae-Min Oh
Keyword(s):  
Layered Double Hydroxide ◽  
Cellular Uptake ◽  
Tumor Targeting ◽  
Cancer Imaging ◽  
Imaging Agent ◽  
Isomorphous Substitution ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

Radioisotope Co-57 substituted LDH were successfully prepared by isomorphous substitution and showed high in vitro cellular uptake and tumor targeting in vivo biodistribution.

Synthesis and Characterization of Near-Infrared Cu−In−Se/ZnS Core/Shell Quantum Dots for In vivo Imaging

2010 ◽  
Vol 22 (22) ◽  
pp. 6117-6124 ◽  
Author(s):  
E. Cassette ◽  
T. Pons ◽  
C. Bouet ◽  
M. Helle ◽  
L. Bezdetnaya ◽  
...  
Keyword(s):  
Quantum Dots ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Synthesis And Characterization ◽  
Core Shell

scholarly journals Recent Progress in the Development of Poly(lactic-co-glycolic acid)-Based Nanostructures for Cancer Imaging and Therapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 280 ◽  
Author(s):  
Ki-Taek Kim ◽  
Jae-Young Lee ◽  
Dae-Duk Kim ◽  
In-Soo Yoon ◽  
Hyun-Jong Cho
Keyword(s):  
Tumor Targeting ◽  
Glycolic Acid ◽  
Cancer Imaging ◽  
Functional Materials ◽  
Plga Nanoparticles ◽  
Clinical Applications ◽  
Internal Space ◽  
Receptor Interactions ◽  
Size Controlled

Diverse nanosystems for use in cancer imaging and therapy have been designed and their clinical applications have been assessed. Among a variety of materials available to fabricate nanosystems, poly(lactic-co-glycolic acid) (PLGA) has been widely used due to its biocompatibility and biodegradability. In order to provide tumor-targeting and diagnostic properties, PLGA or PLGA nanoparticles (NPs) can be modified with other functional materials. Hydrophobic or hydrophilic therapeutic cargos can be placed in the internal space or adsorbed onto the surface of PLGA NPs. Protocols for the fabrication of PLGA-based NPs for cancer imaging and therapy are already well established. Moreover, the biocompatibility and biodegradability of PLGA may elevate its feasibility for clinical application in injection formulations. Size-controlled NP’s properties and ligand–receptor interactions may provide passive and active tumor-targeting abilities, respectively, after intravenous administration. Additionally, the introduction of several imaging modalities to PLGA-based NPs can enable drug delivery guided by in vivo imaging. Versatile platform technology of PLGA-based NPs can be applied to the delivery of small chemicals, peptides, proteins, and nucleic acids for use in cancer therapy. This review describes recent findings and insights into the development of tumor-targeted PLGA-based NPs for use of cancer imaging and therapy.

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