scholarly journals The puzzle of toxicity of gold nanoparticles. The case-study of HeLa cells

2015 ◽  
Vol 4 (4) ◽  
pp. 796-800 ◽  
Author(s):  
Ilaria Fratoddi ◽  
Iole Venditti ◽  
Cesare Cametti ◽  
Maria Vittoria Russo
Keyword(s):  
Gold Nanoparticles ◽  
Hela Cells ◽  
Particle Concentration ◽  
Size And Shape ◽  
Functionalized Gold Nanoparticles

Data on the viability of HeLa cells exposed to functionalized gold nanoparticles have been analyzed on the basis of metrics based on the numerical particle concentration that takes into account both the size and shape of the nanoparticles.

scholarly journals Use in vitro of Gold Nanoparticles Functionalized with Folic Acid as a Photothermal Agent on Treatment of HeLa Cells

2018 ◽  
Vol 62 (1) ◽  
Author(s):  
Linda Bertel Garay ◽  
Fernando Martínez Ortega ◽  
Stelia Carolina Méndez-Sanchez
Keyword(s):  
Gold Nanoparticles ◽  
Folic Acid ◽  
Cancer Cells ◽  
Hela Cells ◽  
Near Infrared ◽  
Infrared Light ◽  
Molar Ratio ◽  
Functionalized Gold Nanoparticles ◽  
Dose Dependent

<p>Folic acid (FA) is used as a recognition molecule to achieve selective internalization in cancer cells. Here functionalized gold nanoparticles with folic acid (AuNP-FA) are proposed as suitable therapeutic agents for cervix cancer cells by photothermal damage. The functionalized gold nanoparticles with folic acid were synthesized by mixing hydrogen tetrachloroaurate with folic acid in a molar ratio of 0.56/1 under radiation of mercury lamp (λ<sub>max</sub>=254 nm). HeLa cells were incubated with AuNP-FA during 48 h, then were irradiated and the cytotoxicity was analyzed 12 h after irradiation. The AuNP-FA were dose-dependent cytotoxic under irradiation and not cytotoxic in the absence of radiation. The viability of cancer cells treated with functionalized and non-functionalized gold nanoparticles (AuNPs), with and without near infrared light at 808 nm, was measured by MTT assays. This work provides useful guidance toward the synthesis of biocompatible nanomaterials for biological applications.</p>

scholarly journals Correction: Poly(adenine)-mediated DNA-functionalized gold nanoparticles for sensitive detection of mercury ions in aqueous media

RSC Advances ◽  
2021 ◽  
Vol 11 (37) ◽  
pp. 22691-22691
Author(s):  
Jinjin Yin ◽  
Jiuchao Wang ◽  
Xiyue Yang ◽  
Tao Wu ◽  
Huashan Wang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Aqueous Media ◽  
Sensitive Detection ◽  
Mercury Ions ◽  
Functionalized Gold Nanoparticles

Correction for ‘Poly(adenine)-mediated DNA-functionalized gold nanoparticles for sensitive detection of mercury ions in aqueous media’ by Jinjin Yin et al., RSC Adv., 2019, 9, 18728–18733, DOI: 10.1039/C9RA03041G.

Functionalized Gold Nanoparticles as Phosphorescent Nanomaterials and Sensors

2006 ◽  
Vol 128 (6) ◽  
pp. 1907-1913 ◽  
Author(s):  
Binil Itty Ipe ◽  
Karuvath Yoosaf ◽  
Kakkudiyil George Thomas
Keyword(s):  
Gold Nanoparticles ◽  
Functionalized Gold Nanoparticles

Inhibition of S. aureus‐Infection of HUVECs by Trehalose and Glucose‐functionalized Gold Nanoparticles

2021 ◽  
Author(s):  
Yimeng Li ◽  
Nicholas Ariotti ◽  
Behnaz Aghaei ◽  
Elvis Pandzic ◽  
Sylvia Ganda ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Aureus Infection ◽  
Functionalized Gold Nanoparticles

scholarly journals X-ray Fluorescence Uptake Measurement of Functionalized Gold Nanoparticles in Tumor Cell Microsamples

2021 ◽  
Vol 22 (7) ◽  
pp. 3691
Author(s):  
Oliver Schmutzler ◽  
Sebastian Graf ◽  
Nils Behm ◽  
Wael Y. Mansour ◽  
Florian Blumendorf ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Irradiation Time ◽  
High Sensitivity ◽  
Nanoparticle Uptake ◽  
X Ray ◽  
Functionalized Gold Nanoparticles ◽  
Uptake Measurement ◽  
Prostate Tumor Cells ◽  
Non Destructive

Quantitative cellular in vitro nanoparticle uptake measurements are possible with a large number of different techniques, however, all have their respective restrictions. Here, we demonstrate the application of synchrotron-based X-ray fluorescence imaging (XFI) on prostate tumor cells, which have internalized differently functionalized gold nanoparticles. Total nanoparticle uptake on the order of a few hundred picograms could be conveniently observed with microsamples consisting of only a few hundreds of cells. A comparison with mass spectroscopy quantification is provided, experimental results are both supported and sensitivity limits of this XFI approach extrapolated by Monte-Carlo simulations, yielding a minimum detectable nanoparticle mass of just 5 pg. This study demonstrates the high sensitivity level of XFI, allowing non-destructive uptake measurements with very small microsamples within just seconds of irradiation time.

Effect of Polymer Chain Length on the Superlattice Assembly of Functionalized Gold Nanoparticles

Langmuir ◽  
2021 ◽  
Author(s):  
Hyeong Jin Kim ◽  
Wenjie Wang ◽  
Honghu Zhang ◽  
Guillaume Freychet ◽  
Benjamin M. Ocko ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Chain Length ◽  
Polymer Chain ◽  
Functionalized Gold Nanoparticles
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