Illustration of SID-IM-SID (surface-induced dissociation-ion mobility-SID) mass spectrometry: homo and hetero model protein complexes

The Analyst ◽  
2015 ◽  
Vol 140 (20) ◽  
pp. 7012-7019 ◽  
Author(s):  
Royston S. Quintyn ◽  
Sophie R. Harvey ◽  
Vicki H. Wysocki
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Protein Complex ◽  
Protein Complexes ◽  
Second Stage ◽  
Surface Induced Dissociation ◽  
Model Protein ◽  
Complex Architecture

Surface collisions generate subcomplexes, which are then separated by ion mobility and dissociated into their individual subunitsviaa second stage of surface collisions to elucidate protein complex architecture and assembly.

scholarly journals Surface induced dissociation as a tool to study membrane protein complexes

2017 ◽  
Vol 53 (21) ◽  
pp. 3106-3109 ◽  
Author(s):  
Sophie R. Harvey ◽  
Yang Liu ◽  
Wen Liu ◽  
Vicki H. Wysocki ◽  
Arthur Laganowsky
Keyword(s):  
Mass Spectrometry ◽  
Membrane Protein ◽  
Ion Mobility ◽  
Protein Complexes ◽  
Integral Membrane Protein ◽  
Ion Mobility Mass Spectrometry ◽  
Surface Induced Dissociation ◽  
Membrane Protein Complexes

Native ion mobility mass spectrometry (MS) and surface induced dissociation (SID) are applied to study the integral membrane protein complexes AmtB and AqpZ.

scholarly journals Mass Spectrometry in Structural Biology: Surface‐induced Dissociation/Ion Mobility of Protein Complexes

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Vicki Wysocki ◽  
Royston Quintyn ◽  
Sophie Harvey ◽  
Yang Song ◽  
Jing Yan ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Structural Biology ◽  
Ion Mobility ◽  
Protein Complexes ◽  
Surface Induced Dissociation

scholarly journals Localization of Protein Complex Bound Ligands by Surface-Induced Dissociation High-Resolution Mass Spectrometry

2018 ◽  
Vol 90 (21) ◽  
pp. 12796-12801 ◽  
Author(s):  
Florian Busch ◽  
Zachary L. VanAernum ◽  
Yue Ju ◽  
Jing Yan ◽  
Joshua D. Gilbert ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Protein Complex ◽  
High Resolution Mass Spectrometry ◽  
Surface Induced Dissociation ◽  
High Resolution Mass ◽  
Resolution Mass

Ion Mobility–Mass Spectrometry Reveals Long-Lived, Unfolded Intermediates in the Dissociation of Protein Complexes

2007 ◽  
Vol 46 (42) ◽  
pp. 8001-8004 ◽  
Author(s):  
Brandon T. Ruotolo ◽  
Suk-Joon Hyung ◽  
Paula M. Robinson ◽  
Kevin Giles ◽  
Robert H. Bateman ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Protein Complexes ◽  
Ion Mobility Mass Spectrometry
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