A general metal-free route towards the synthesis of 1,2,3-triazoles from readily available primary amines and ketones

2016 ◽  
Vol 52 (14) ◽  
pp. 2885-2888 ◽  
Author(s):  
Joice Thomas ◽  
Sampad Jana ◽  
Jubi John ◽  
Sandra Liekens ◽  
Wim Dehaen
Keyword(s):  
Natural Products ◽  
Primary Amines ◽  
Metal Free ◽  
Amino Esters

A metal-free route towards different 1,2,3-triazole heterocycles was accomplished by using inexpensive and readily available ketones and primary amines. This reaction is very general and was extended to functionalize different amino esters, dendrimers and natural products.

Formation of Carbon-Oxygen Bond Mediated by Hypervalent Iodine Reagents Under Metal-free Conditions

2020 ◽  
Vol 17 ◽  
Author(s):  
Ayesha Jalil ◽  
Yaxin O Yang ◽  
Zhendong Chen ◽  
Rongxuan Jia ◽  
Tianhao Bi ◽  
...  
Keyword(s):  
Natural Products ◽  
Bond Formation ◽  
Building Blocks ◽  
Review Article ◽  
Hypervalent Iodine ◽  
Metal Free ◽  
Bioactive Natural Products ◽  
The Past ◽  
Oxygen Bond ◽  
Privileged Scaffolds

: Hypervalent iodine reagents are a class of non-metallic oxidants have been widely used in the construction of several sorts of bond formations. This surging interest in hypervalent iodine reagents is essentially due to their very useful oxidizing properties, combined with their benign environmental character and commercial availability from the past few decades ago. Furthermore, these hypervalent iodine reagents have been used in the construction of many significant building blocks and privileged scaffolds of bioactive natural products. The purpose of writing this review article is to explore all the transformations in which carbon-oxygen bond formation occurred by using hypervalent iodine reagents under metal-free conditions

scholarly journals Metal-Free Air Oxidation in a Convenient Cascade Approach for the Access to Isoquinoline-1,3,4(2H)-triones

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2177
Author(s):  
Antonia Di Mola ◽  
Consiglia Tedesco ◽  
Antonio Massa
Keyword(s):  
Heterocyclic Compounds ◽  
Aromatic Ketone ◽  
Primary Amines ◽  
Cascade Process ◽  
Staudinger Reaction ◽  
Caspase Inhibitor ◽  
Air Oxidation ◽  
Metal Free ◽  
Free Air

Herein we describe a very useful application of the readily available trifunctional aromatic ketone methyl-2-(2-bromoacetyl)benzoate in reactions with primary amines. An unexpected in situ air oxidation that follows a cascade process allowed the access to a series of isoquinoline-1,3,4(2H)-triones, a class of heterocyclic compounds of great interest containing an oxygen-rich heterocyclic scaffold. A modification of the original protocol, utilizing a Staudinger reaction in the presence of trimethylphosphine, was necessary for the synthesis of Caspase inhibitor trione with free NH group.

Synthesis of 2-Aryl-5-alkyl-fulleropyrrolidines: Metal-Free-Mediated Reaction of [60]Fullerene with Aromatic Aldehydes and Inactive Primary Amines

2017 ◽  
Vol 82 (16) ◽  
pp. 8617-8627 ◽  
Author(s):  
Meng Zhang ◽  
Hui-Juan Wang ◽  
Fa-Bao Li ◽  
Xin-Xin Zhong ◽  
Yong-Shun Huang ◽  
...  
Keyword(s):  
Aromatic Aldehydes ◽  
Primary Amines ◽  
Metal Free

ChemInform Abstract: Direct Amination of 2-(1-Tosylalkyl)phenols with Aqueous Ammonia: A Metal-Free Synthesis of Primary Amines.

ChemInform ◽  
2015 ◽  
Vol 46 (26) ◽  
pp. no-no
Author(s):  
Bo Wu ◽  
Xiang Gao ◽  
Mu-Wang Chen ◽  
Yong-Gui Zhou
Keyword(s):  
Aqueous Ammonia ◽  
Primary Amines ◽  
Direct Amination ◽  
Metal Free

Beyond conventional construction of phthalimide core: A review

2021 ◽  
Author(s):  
Suven Das
Keyword(s):  
Natural Products ◽  
Organic Materials ◽  
Structural Motif ◽  
Primary Amines ◽  
Common Strategy ◽  
Phthalic Acids

Phthalimides are privileged structural motif frequently found in natural products, pharmaceuticals and organic materials. The Most common strategy for their synthesis involves condensation of phthalic acids/anhydrides with primary amines. However,...

ChemInform Abstract: A Metal-Free Oxidative Amination of Benzoxazoles with Primary Amines and Ammonia.

ChemInform ◽  
2012 ◽  
Vol 43 (17) ◽  
pp. no-no
Author(s):  
Ulrich Kloeckner ◽  
Nicole M. Weckenmann ◽  
Boris J. Nachtsheim
Keyword(s):  
Primary Amines ◽  
Oxidative Amination ◽  
Metal Free

Decarboxylative dipropargylation of primary amines with propiolic acids and formaldehyde via metal-free coupling

Tetrahedron ◽  
2015 ◽  
Vol 71 (18) ◽  
pp. 2724-2728 ◽  
Author(s):  
Huihui Jia ◽  
Huangdi Feng ◽  
Zhihua Sun
Keyword(s):  
Primary Amines ◽  
Metal Free

Mild Access to N-Formylation of Primary Amines using Ethers as C1 Synthons under Metal-Free Conditions

2018 ◽  
Vol 360 (20) ◽  
pp. 3960-3968 ◽  
Author(s):  
Mohana Reddy Mutra ◽  
Ganesh Kumar Dhandabani ◽  
Jeh-Jeng Wang
Keyword(s):  
Primary Amines ◽  
Metal Free
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