Synthesis and mode of action of oligomeric sesquiterpene lactones

2016 ◽  
Vol 33 (5) ◽  
pp. 602-611 ◽  
Author(s):  
Chao Li ◽  
Alexander X. Jones ◽  
Xiaoguang Lei
Keyword(s):  
Case Studies ◽  
Mode Of Action ◽  
Sesquiterpene Lactones ◽  
Biological Mechanism

In this highlight we describe two case studies from our laboratory, involving the biomimetic syntheses and the biological mechanism elucidation of the bioactive oligomeric sesquiterpenoids, (+)-ainsliadimer A (4) and (−)-ainsliatrimer A (5).

scholarly journals Epistemic values of quantity and variety of evidence in biological mechanism research

2021 ◽  
Vol 11 (2) ◽  
Author(s):  
Yin Chung Au
Keyword(s):  
Experimental Data ◽  
Causal Inference ◽  
Case Studies ◽  
Biological Mechanism ◽  
Data Generation ◽  
Extended Version ◽  
Epistemic Values ◽  
Difference Making ◽  
Mechanism Research ◽  
The Difference

AbstractThis paper proposes an extended version of the interventionist account for causal inference in the practical context of biological mechanism research. This paper studies the details of biological mechanism researchers’ practices of assessing the evidential legitimacy of experimental data, arguing why quantity and variety are two important criteria for this assessment. Because of the nature of biological mechanism research, the epistemic values of these two criteria result from the independence both between the causation of data generation and the causation in question and between different interventions, not techniques. The former independence ensures that the interventions in the causation in question are not affected by the causation that is responsible for data generation. The latter independence ensures the reliability of the final mechanisms not only in the empirical but also the formal aspects. This paper first explores how the researchers use quantity to check the effectiveness of interventions, where they at the same time determine the validity of the difference-making revealed by the results of interventions. Then, this paper draws a distinction between experimental interventions and experimental techniques, so that the reliability of mechanisms, as supported by the variety of evidence, can be safely ensured in the probabilistic sense. The latter process is where the researchers establish evidence of the mechanisms connecting the events of interest. By using case studies, this paper proposes to use ‘intervention’ as the fruitful connecting point of literature between evidence and mechanisms.

scholarly journals Mode of Action of the Sesquiterpene Lactones Psilostachyin and Psilostachyin C on Trypanosoma cruzi

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0150526 ◽  
Author(s):  
Valeria P. Sülsen ◽  
Vanesa Puente ◽  
Daniela Papademetrio ◽  
Alcira Batlle ◽  
Virginia S. Martino ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Mode Of Action ◽  
Sesquiterpene Lactones

Synergistic Insecticidal Mode of Action between Sesquiterpene Lactones and a Phototoxin, α-Terthienyl

2007 ◽  
Vol 71 (2) ◽  
pp. 111-115
Author(s):  
Gabriel Guillet ◽  
Juraj Harmatha ◽  
Thomas G. Waddell ◽  
Bernard J. R. Philogène ◽  
John T. Arnason
Keyword(s):  
Mode Of Action ◽  
Sesquiterpene Lactones

Cardiac-inhibiting properties of the sesquiterpene lactone, parthenin, in the migratory grasshopper, Melanoplus sanguinipes

1981 ◽  
Vol 59 (2) ◽  
pp. 285-292 ◽  
Author(s):  
Anna K. Picman ◽  
R. H. Elliott ◽  
G. H. N. Towers
Keyword(s):  
Glutamic Acid ◽  
Plant Defense ◽  
Sesquiterpene Lactone ◽  
Mode Of Action ◽  
Reduced Glutathione ◽  
Sesquiterpene Lactones ◽  
Melanoplus Sanguinipes ◽  
Inhibitory Effects ◽  
Lethal Effects ◽  
Sulphydryl Groups

The cardiac-inhibiting properties of the sesquiterpene lactone, parthenin, were examined on semiisolated heart preparations of the migratory grasshopper, Melanoplus sanguinipes. Compared with saline-treated hearts, 0.3 mM parthenin significantly increased the frequency of heartbeat. However, higher concentrations of parthenin (3.4–51.3 mM) were progressively more inhibitory and caused a cessation in heartbeat within 1 h after application.Parthenin-arrested hearts treated with reduced glutathione, DL-cystathionine, acetylcholine, or L-glutamic acid remained inactive. In contrast, L-cysteine, DL-homocysteine, or dithiothreitol (DTT) reinitiated heartbeat in parthenin-arrested hearts. When the isolated monoadduct of parthenin and cysteine was applied to heart preparations, no inhibitory effects were apparent. The inhibitory effects of parthenin could also be delayed or prevented by mixing the compound with equimolar concentrations of cysteine, homocysteine, or DTT prior to its application to the heart. Because certain thiol agents negate or neutralize the cardiac-inhibiting properties of parthenin, the findings suggest that the lethal effects of sesquiterpene lactones on insects are due, in part, to an interference with free sulphydryl groups which appear essential to normal cardiac activity.The implications of these findings are discussed in terms of the mode of action, detoxification, and importance of parthenin in plant defense.

Symposium-in-Print Synergistic Insecticidal Mode of Action between Sesquiterpene Lactones and a Phototoxin, α-Terthienyl

2000 ◽  
Vol 71 (2) ◽  
pp. 111 ◽  
Author(s):  
Gabriel Guillet ◽  
Juraj Harmatha ◽  
Thomas G. Waddell ◽  
Bernard J. R. Philogène ◽  
John T. Arnason
Keyword(s):  
Mode Of Action ◽  
Sesquiterpene Lactones

Mode of action of sesquiterpene lactones as anti-inflammatory agents

1980 ◽  
Vol 69 (5) ◽  
pp. 537-543 ◽  
Author(s):  
I.H. Hall ◽  
C.O. Starnes ◽  
K.H. Lee ◽  
T.G. Waddell
Keyword(s):  
Mode Of Action ◽  
Sesquiterpene Lactones ◽  
Anti Inflammatory

Mode of action of the sesquiterpene lactones eupatoriopicrin and estafietin on Trypanosoma cruzi

Phytomedicine ◽  
2021 ◽  
pp. 153900
Author(s):  
Orlando G. Elso ◽  
Vanesa Puente ◽  
Patricia Barrera ◽  
Miguel A. Sosa-Escudero ◽  
Valeria P. Sülsen ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Mode Of Action ◽  
Sesquiterpene Lactones

Prediction of modes of action of components of traditional medicinal preparations

2019 ◽  
Vol 5 (2) ◽  
Author(s):  
Fatima Baldo
Keyword(s):  
Natural Products ◽  
Traditional Medicine ◽  
Case Studies ◽  
Mode Of Action ◽  
Traditional Methods ◽  
Modes Of Action ◽  
Biochemical Methods ◽  
Medicinal Preparations ◽  
The World ◽  
Multiple Regions

Abstract Traditional medicine preparations are used to treat many ailments in multiple regions across the world. Despite their widespread use, the mode of action of these preparations and their constituents are not fully understood. Traditional methods of elucidating the modes of action of these natural products (NPs) can be expensive and time consuming e. g. biochemical methods, bioactivity guided fractionation, etc. In this review, we discuss some methods for the prediction of the modes of action of traditional medicine preparations, both in mixtures and as isolated NPs. These methods are useful to predict targets of NPs before they are experimentally validated. Case studies of the applications of these methods are also provided herein.

scholarly journals Living Contexts of Non-Take-Up in Germany

2021 ◽  
Vol 47 (2) ◽  
pp. 261-282
Author(s):  
Jennifer Eckhardt
Keyword(s):  
Case Studies ◽  
Empirical Research ◽  
Mode Of Action ◽  
Social Benefits ◽  
Research Areas

Abstract This article focuses on the refusal of social benefits in Germany from the perspectives of people who practice it. Through the presentation of three case studies, forms of subjectivation are reconstructed which offer insights into societal origins of refusal as an everyday mode of action and point towards further thematic and empirical research areas.

ChemInform Abstract: Synthesis and Mode of Action of Oligomeric Sesquiterpene Lactones

ChemInform ◽  
2016 ◽  
Vol 47 (29) ◽  
Author(s):  
Chao Li ◽  
Alexander X. Jones ◽  
Xiaoguang Lei
Keyword(s):  
Mode Of Action ◽  
Sesquiterpene Lactones
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