scholarly journals Epistemic values of quantity and variety of evidence in biological mechanism research

2021 ◽  
Vol 11 (2) ◽  
Author(s):  
Yin Chung Au
Keyword(s):  
Experimental Data ◽  
Causal Inference ◽  
Case Studies ◽  
Biological Mechanism ◽  
Data Generation ◽  
Extended Version ◽  
Epistemic Values ◽  
Difference Making ◽  
Mechanism Research ◽  
The Difference

AbstractThis paper proposes an extended version of the interventionist account for causal inference in the practical context of biological mechanism research. This paper studies the details of biological mechanism researchers’ practices of assessing the evidential legitimacy of experimental data, arguing why quantity and variety are two important criteria for this assessment. Because of the nature of biological mechanism research, the epistemic values of these two criteria result from the independence both between the causation of data generation and the causation in question and between different interventions, not techniques. The former independence ensures that the interventions in the causation in question are not affected by the causation that is responsible for data generation. The latter independence ensures the reliability of the final mechanisms not only in the empirical but also the formal aspects. This paper first explores how the researchers use quantity to check the effectiveness of interventions, where they at the same time determine the validity of the difference-making revealed by the results of interventions. Then, this paper draws a distinction between experimental interventions and experimental techniques, so that the reliability of mechanisms, as supported by the variety of evidence, can be safely ensured in the probabilistic sense. The latter process is where the researchers establish evidence of the mechanisms connecting the events of interest. By using case studies, this paper proposes to use ‘intervention’ as the fruitful connecting point of literature between evidence and mechanisms.

scholarly journals Three-Dimensional Structures of Carbohydrates and Where to Find Them

2020 ◽  
Vol 21 (20) ◽  
pp. 7702 ◽  
Author(s):  
Sofya I. Scherbinina ◽  
Philip V. Toukach
Keyword(s):  
Experimental Data ◽  
Molecular Modeling ◽  
Computational Methods ◽  
Three Dimensional ◽  
Structural Diversity ◽  
Structural Data ◽  
Structural Features ◽  
Data Validation ◽  
Data Generation ◽  
Efficient Treatment

Analysis and systematization of accumulated data on carbohydrate structural diversity is a subject of great interest for structural glycobiology. Despite being a challenging task, development of computational methods for efficient treatment and management of spatial (3D) structural features of carbohydrates breaks new ground in modern glycoscience. This review is dedicated to approaches of chemo- and glyco-informatics towards 3D structural data generation, deposition and processing in regard to carbohydrates and their derivatives. Databases, molecular modeling and experimental data validation services, and structure visualization facilities developed for last five years are reviewed.

Drained instability of sand in plane strain

2010 ◽  
Vol 47 (4) ◽  
pp. 400-412 ◽  
Author(s):  
Dariusz Wanatowski ◽  
Jian Chu ◽  
Wai Lay Loke
Keyword(s):  
Experimental Data ◽  
Plane Strain ◽  
Case Studies ◽  
Static Loading ◽  
State Parameter ◽  
Dam Failure ◽  
Triaxial Tests ◽  
Granular Soil ◽  
Laboratory Studies ◽  
Dense Sand

Flowslide or failure of loose granular soil slopes is often explained using liquefaction or instability data obtained from undrained triaxial tests. However, under static loading conditions, the assumption of an undrained condition is not realistic for sand, particularly clean sand. Case studies have indicated that instability of granular soil can occur under essentially drained conditions (e.g., the Wachusett Dam failure in 1907). Laboratory studies on Changi sand by Chu et al. in 2003 have shown that sand can become unstable under completely drained conditions. However, these studies were carried out under axisymmetric conditions and thus, cannot be applied directly to the analysis of slope failures. In this paper, experimental data obtained from plane-strain tests are presented to study the instability behaviour of loose and dense sand under plane-strain conditions. Based on these test data, the conditions for the occurrence of drained instability in plane strain are established. Using the modified state parameter, the conditions for instability under both axisymmetric and plane-strain conditions can be unified. A framework for interpreting the instability conditions of sandy slopes developed under axisymmetric conditions also extends into plane-strain conditions.

Dose-window dependence on Si crystal orientation in separation by implanted oxygen substrate formation

2004 ◽  
Vol 19 (12) ◽  
pp. 3607-3613 ◽  
Author(s):  
H. Iikawa ◽  
M. Nakao ◽  
K. Izumi
Keyword(s):  
Experimental Data ◽  
Numerical Analysis ◽  
Crystal Orientation ◽  
Oxygen Ion ◽  
The Difference ◽  
First Time ◽  
Good Agreement

Separation by implemented oxygen (SIMOX)(111) substrates have been formed by oxygen-ion (16O+) implantation into Si(111), showing that a so-called “dose-window” at 16O+-implantation into Si differs from Si(100) to Si(111). In SIMOX(100), an oxygen dose of 4 × 1017/cm2 into Si(100) is widely recognized as the dose-window when the acceleration energy is 180 keV. For the first time, our work shows that an oxygen dose of 5 × 1017/cm2 into Si(111) is the dose-window for the formation of SIMOX(111) substrates when the acceleration energy is 180 keV. The difference between dose-windows is caused by anisotropy of the crystal orientation during growth of the faceted buried SiO2. We also numerically analyzed the data at different oxidation velocities for each facet of the polyhedral SiO2 islands. Numerical analysis results show good agreement with the experimental data.

The Tensile Property of the SPF/Cotton Blended Yarn

2011 ◽  
Vol 321 ◽  
pp. 192-195
Author(s):  
Qing Bin Yang ◽  
Xiao Yang
Keyword(s):  
Experimental Data ◽  
Simple Model ◽  
Tensile Property ◽  
Cotton Fibers ◽  
Blended Yarn ◽  
The Difference ◽  
The Relationship

In order to analysis the relationship between the strength and elongation and the blended ratio of SPF/Cotton blended yarn, the strength and elongation of SPF /cotton blended yarn with different blended ratio were measured and compared with the simple model. The results indicated that For the SPF/cotton blended yarn, the difference between the experimental data and the model value is remarkable because of the high cohesion of the cotton fibers.

Naturalized Aesthetics and Emotion Theory

Projections ◽  
2018 ◽  
Vol 12 (2) ◽  
pp. 76-85 ◽  
Author(s):  
Rainer Reisenzein
Keyword(s):  
Empirical Evidence ◽  
Case Studies ◽  
Integrated System ◽  
Third Culture ◽  
Extended Version ◽  
Basic Emotions ◽  
The Third ◽  
Psychological Theories ◽  
Concrete Application ◽  
Emotion Theory

Murray Smith’s proposal in Film, Art, and the Third Culture for a naturalized aesthetics is of interest to both film theorists and psychologists: for the former, it helps to elucidate how films work; for the latter, it provides concrete application cases of psychological theories. However, there are reasons for believing that the theory of emotions that Smith has adopted from psychology to ground his case studies—an extended version of basic emotions theory—is less well supported than he suggests. The available empirical evidence seems more compatible with the assumption that the different emotions are outputs of a single, integrated system.

scholarly journals THE PROBLEMS EXPERIMENT MODELING UNDER IMPACT OF TORN VANE WITH TURBOJET FAN CASE

2020 ◽  
pp. 5-11
Author(s):  
Vladimir Kurteyev ◽  
◽  
Boris Mozerov ◽  
Keyword(s):  
Experimental Data ◽  
Laboratory Experiment ◽  
Plane Model ◽  
Cylindrical Model ◽  
Calculation Results ◽  
The Difference

There is studied the problems experiment modeling under impact of torn vane with turbojet fan case. There are outlined shortcomings of equipment for plane and cylindrical model cases testing. There is indicated the difference between calculation results and experimental data for metals plane models. There are indicated diagram laboratory experiment installation on basic pressurized balloons for testing metals plane models. There are calculated parameters of metals plane model with the point of views criterion modeling.

scholarly journals Моделирование проводимости Капицы через шероховатые интерфейсы между твердыми телами

2021 ◽  
Vol 63 (7) ◽  
pp. 982
Author(s):  
Б. Лю ◽  
В.И. Хвесюк ◽  
А.А. Баринов
Keyword(s):  
Experimental Data ◽  
Theoretical Prediction ◽  
Transmission Coefficient ◽  
Wide Temperature Range ◽  
Acoustic Waves ◽  
Theoretical Method ◽  
Interface Roughness ◽  
Kapitza Conductance ◽  
Acoustic Mismatch ◽  
The Difference

In this work, we have formulated and solved the problem of determining the Kapitza conductance across the interface between two solids, taking into account the interface roughness. We use a modified acoustic mismatch model (AMM). The difference from the classic model is that the dispersion properties of acoustic waves are considered. A significant advantage of this model is that the theoretical prediction agrees well with experimental data over a wide temperature range: from 30K to more than 300K. Finally, a theoretical method with the statistical distribution of roughness profiles is used to determine the energy transmission coefficient across the interface.

scholarly journals A sparse modeling for small data: Case studies in controlled syntheses of 2D materials

2022 ◽  
Author(s):  
Yuri Haraguchi ◽  
Yasuhiko Igarashi ◽  
Hiroaki Imai ◽  
Yuya Oaki
Keyword(s):  
Experimental Data ◽  
Case Studies ◽  
Materials Science ◽  
2D Materials ◽  
Small Data ◽  
Sparse Modeling

Data-scientific approaches have permeated in chemistry and materials science. In general, these approaches are not easily applied to small data, such as experimental data in laboratories. Our group has focused...

scholarly journals Neuronal Coherence Agent for Shared Intentionality: A Hypothesis of Neurobiological Processes Occurring during Social Interaction

2021 ◽  
Vol 5 (4) ◽  
pp. 1-1
Author(s):  
Igor Val Danilov ◽  
◽  
Sandra Mihailova ◽  
Keyword(s):  
Social Interaction ◽  
Case Studies ◽  
Present Report ◽  
Biological Systems ◽  
Long Term Potentiation ◽  
Evolutionary Development ◽  
Entire Group ◽  
Shared Intentionality ◽  
The Difference ◽  
Neuronal Coherence

The present interdisciplinary study discusses the physical foundations of the neurobiological processes occurring during social interaction. The review of the literature establishes the difference between Intentionality and Intention, thereby proposing the theoretical basis of Shared Intentionality in humans. According to the present study, Shared Intentionality in humans (Goal-directed coherence of biological systems), which is the ability among social organisms to instantly select just one stimulus for the entire group, is the outcome of evolutionary development. Therefore, this interaction modality should be the preferred, archetypal, and most propagated modality in organisms, attributed to the Model of Hierarchical Complexity Stage 3. This characteristic of biological systems facilitates the training of the new members of the group and also ensures efficient cooperation among the members of the group without requiring communication. In humans, Shared Intentionality contributes to the learning of newborns. The neurons of a mature organism may teach the neonate neurons regarding the fitting reactions to the excitatory inputs of the specific structural organization. This enables the neonate neurons to develop a Long-Term Potentiation that links particular stimuli with specific embodied sensorimotor neural networks. The present report discusses three possible neuronal coherence agents that could involve quantum mechanisms in cells, thereby enabling the distribution of the quality of goal-directed coherence in biological systems (Shared Intentionality in humans). Recently reported case studies conducted online with the task of conveying the meaning of numerosity to the children of age 18–33 months revealed the occurrence of Shared Intentionality in mother-child dyads in the absence of sensory cues between the two, which promoted cognitive development in the children. The findings of these case studies support the concept of physical foundations and the hypothesis of the neurophysiological process of social interaction proposed in the present study.

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