Cardiac-inhibiting properties of the sesquiterpene lactone, parthenin, in the migratory grasshopper, Melanoplus sanguinipes

1981 ◽  
Vol 59 (2) ◽  
pp. 285-292 ◽  
Author(s):  
Anna K. Picman ◽  
R. H. Elliott ◽  
G. H. N. Towers
Keyword(s):  
Glutamic Acid ◽  
Plant Defense ◽  
Sesquiterpene Lactone ◽  
Mode Of Action ◽  
Reduced Glutathione ◽  
Sesquiterpene Lactones ◽  
Melanoplus Sanguinipes ◽  
Inhibitory Effects ◽  
Lethal Effects ◽  
Sulphydryl Groups

The cardiac-inhibiting properties of the sesquiterpene lactone, parthenin, were examined on semiisolated heart preparations of the migratory grasshopper, Melanoplus sanguinipes. Compared with saline-treated hearts, 0.3 mM parthenin significantly increased the frequency of heartbeat. However, higher concentrations of parthenin (3.4–51.3 mM) were progressively more inhibitory and caused a cessation in heartbeat within 1 h after application.Parthenin-arrested hearts treated with reduced glutathione, DL-cystathionine, acetylcholine, or L-glutamic acid remained inactive. In contrast, L-cysteine, DL-homocysteine, or dithiothreitol (DTT) reinitiated heartbeat in parthenin-arrested hearts. When the isolated monoadduct of parthenin and cysteine was applied to heart preparations, no inhibitory effects were apparent. The inhibitory effects of parthenin could also be delayed or prevented by mixing the compound with equimolar concentrations of cysteine, homocysteine, or DTT prior to its application to the heart. Because certain thiol agents negate or neutralize the cardiac-inhibiting properties of parthenin, the findings suggest that the lethal effects of sesquiterpene lactones on insects are due, in part, to an interference with free sulphydryl groups which appear essential to normal cardiac activity.The implications of these findings are discussed in terms of the mode of action, detoxification, and importance of parthenin in plant defense.

scholarly journals Carbaryl and Human Health: A Review

2018 ◽  
Vol 2 (5) ◽  
Author(s):  
Atreyee Sahana ◽  
Soumik Agarwal
Keyword(s):  
Human Health ◽  
Mode Of Action ◽  
Reduced Glutathione ◽  
Melatonin Receptors ◽  
Carcinogenic Activity ◽  
Glutathione Conjugate ◽  
Biochemical Effects ◽  
Carbamate Insecticides ◽  
Sulphydryl Groups

Carbaryl (1-naphthalenylmethylcarbamate) is one of the most frequently used carbamate insecticides. Carbaryl has elicited some serious carcinogenic activity in the chronic rodent studies and has also been found to cause tumors in the liver. Though carbaryl is relatively safe to mammals, but carbaryl causes damage to hepatocytes. It has other biochemical effects, as it reacts with reduced glutathione and probably directly with other accessible protein hydroxyl and sulphydryl groups or indirectly through reactions involving the glutathione conjugate. In mammals, carbaryl inhibits acetylcholinesterase causing several neural problems. Some recent reports suggest it can bind human melatonin receptors exerting serious implications on human health. Here in this review an attempt has been made to summarise carbaryl’s mode of action and its ill effects on human health.

Anticancer Potential of Aguerin B, a Sesquiterpene Lactone Isolated from Centaurea behen in Metastatic Breast Cancer Cells

2020 ◽  
Vol 15 (2) ◽  
pp. 165-173
Author(s):  
Elaheh Amini ◽  
Mohammad Nabiuni ◽  
Seyed Bahram Behzad ◽  
Danial Seyfi ◽  
Farhad Eisvand ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Tumor Cell ◽  
Sesquiterpene Lactone ◽  
Sesquiterpene Lactones ◽  
Metastatic Breast ◽  
Breast Adenocarcinoma ◽  
Human Breast ◽  
Skin Malignancy

Background: Breast carcinoma is a malignant disease that represents the most common non-skin malignancy and a chief reason of cancer death in women. Large interest is growing in the use of natural products for cancer treatment, especially with goal of suppression angiogenesis, tumor cell growth, motility, as well as invasion and metastasis with low/no toxicity. It is evident from recent patents on the anticancer properties of sesquiterpene lactones such as parthenolide. Objective: In this study, using MDA-MB-231 cells of a human breast adenocarcinoma, the effects of aguerin B, as a natural sesquiterpene lactone, has been evaluated, in terms of the expression of metastatic-related genes (Pak-1, Rac-1 and HIF-1α). Methods: Cytotoxicity of aguerin B was tested toward MDA-MB-231 breast tumor cells using MTT. Scratch assay was accomplished to evaluate the tumor cell invasion. To understand the underlying molecular basis, the mRNA expressions were evaluated by real time PCR. Results: It was found that aguerin B significantly inhibited human breast cancer cell growth in vitro (IC50 = 2μg/mL) and this effect was accompanied with a persuasive suppression on metastasis. Our results showed that aguerin B in IC50 concentration down-regulated Rac-1, Pak-1, Hif-1α and Zeb-1 transcriptional levels. Conclusion: Taken together, this study demonstrated that aguerin B possessed potential anti-metastatic effect, suggesting that it may consider as a potential multi target bio compound for treatment of breast metastatic carcinoma.

scholarly journals Mode of Action of the Sesquiterpene Lactones Psilostachyin and Psilostachyin C on Trypanosoma cruzi

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0150526 ◽  
Author(s):  
Valeria P. Sülsen ◽  
Vanesa Puente ◽  
Daniela Papademetrio ◽  
Alcira Batlle ◽  
Virginia S. Martino ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Mode Of Action ◽  
Sesquiterpene Lactones

EFFECTS OF HYPOGLYCIN A ON THE METABOLISM OF AMINO ACIDS BY LIVER SLICES

1964 ◽  
Vol 42 (1) ◽  
pp. 139-142 ◽  
Author(s):  
S. J. Patrick ◽  
L. C. Stewart
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Glutamic Acid ◽  
Rat Liver ◽  
Inhibitory Effects ◽  
Liver Slices

The effects of hypoglycin A on the metabolism of L-leucine-C14, L-alanine-C14, and L-glutamic-acid-C14 by rat liver slices have been investigated. Hypoglycin exerted markedly inhibitory effects on the conversion of leucine-C14 to fatty acid, cholesterol, and CO2. Conversion of alanine-C14 and glutamic acid-C14 to fatty acids was also inhibited by hypoglycin. No effects of hypoglycin on the conversion of C14-amino acids into protein or glycogen were demonstrated.

Synergistic Insecticidal Mode of Action between Sesquiterpene Lactones and a Phototoxin, α-Terthienyl

2007 ◽  
Vol 71 (2) ◽  
pp. 111-115
Author(s):  
Gabriel Guillet ◽  
Juraj Harmatha ◽  
Thomas G. Waddell ◽  
Bernard J. R. Philogène ◽  
John T. Arnason
Keyword(s):  
Mode Of Action ◽  
Sesquiterpene Lactones

scholarly journals Coordination chemistry of glutathione.

1999 ◽  
Vol 46 (3) ◽  
pp. 567-580 ◽  
Author(s):  
A Krezel ◽  
W Bal
Keyword(s):  
Glutamic Acid ◽  
Metal Ions ◽  
Metal Ion ◽  
Reduced Glutathione ◽  
Transition Metal Ions ◽  
Oxidized Glutathione ◽  
Binding Modes ◽  
Glutamic Acid Residue ◽  
Reduced And Oxidized Glutathione ◽  
Soft Metal

The metal ion coordination abilities of reduced and oxidized glutathione are reviewed. Reduced glutathione (GSH) is a very versatile ligand, forming stable complexes with both hard and soft metal ions. Several general binding modes of GSH are described. Soft metal ions coordinate exclusively or primarily through thiol sulfur. Hard ones prefer the amino acid-like moiety of the glutamic acid residue. Several transition metal ions can additionally coordinate to the peptide nitrogen of the gamma-Glu-Cys bond. Oxidized glutathione lacks the thiol function. Nevertheless, it proves to be a surprisingly efficient ligand for a range of metal ions, coordinating them primarily through the donors of the glutamic acid residue.

scholarly journals New Sesquiterpene Lactone and Other Constituents from Centaurea sulphurea (Asteraceae)

2010 ◽  
Vol 5 (6) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Hichem Lakhal ◽  
Tarek Boudiar ◽  
Ahmed Kabouche ◽  
Zahia Kabouche ◽  
Rachid Touzani ◽  
...  
Keyword(s):  
Sesquiterpene Lactone ◽  
Endemic Species ◽  
Sesquiterpene Lactones ◽  
First Time

Five known flavonoids (1-5) and three sesquiterpene lactones (6-8) are reported for the first time from the endemic species Centaurea sulphurea Willd. (Asteraceae). Compound 7 is a new heliangolide (6 R, 7 R, 8 S, 3' R)-8α-(3’,4’-dihydroxy-methylene-2’-butanoyloxy)-15-oxo-helianga-1(10), 4(5), 11(13)-trien-6,12-olide, named as sulphurein.

Guaiane Sesquiterpene Lactones and Amino Acid-Sesquiterpene Lactone Conjugates from the Aerial Parts ofSaussurea pulchella

2008 ◽  
Vol 71 (4) ◽  
pp. 678-683 ◽  
Author(s):  
Min Cheol Yang ◽  
Sang Un Choi ◽  
Wahn Soo Choi ◽  
Sun Yeou Kim ◽  
Kang Ro Lee
Keyword(s):  
Amino Acid ◽  
Sesquiterpene Lactone ◽  
Sesquiterpene Lactones ◽  
Aerial Parts
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