Prediction of modes of action of components of traditional medicinal preparations

2019 ◽  
Vol 5 (2) ◽  
Author(s):  
Fatima Baldo
Keyword(s):  
Natural Products ◽  
Traditional Medicine ◽  
Case Studies ◽  
Mode Of Action ◽  
Traditional Methods ◽  
Modes Of Action ◽  
Biochemical Methods ◽  
Medicinal Preparations ◽  
The World ◽  
Multiple Regions

Abstract Traditional medicine preparations are used to treat many ailments in multiple regions across the world. Despite their widespread use, the mode of action of these preparations and their constituents are not fully understood. Traditional methods of elucidating the modes of action of these natural products (NPs) can be expensive and time consuming e. g. biochemical methods, bioactivity guided fractionation, etc. In this review, we discuss some methods for the prediction of the modes of action of traditional medicine preparations, both in mixtures and as isolated NPs. These methods are useful to predict targets of NPs before they are experimentally validated. Case studies of the applications of these methods are also provided herein.

scholarly journals Hydroxychloroquine for the Treatment of COVID-19: Evidence, Possible Mode of Action and Industrial Supply of the Drug

2020 ◽  
Author(s):  
Mario Pagliaro ◽  
Francesco Meneguzzo
Keyword(s):  
Mode Of Action ◽  
Early Phase ◽  
Scale Up ◽  
Modes Of Action ◽  
The World ◽  
Staying At Home ◽  
At Home

Hydroxychloroquine, a known antiviral metabolite of chloroquine, is increasingly used along with antibiotic azithromycin for the treatment of COVID-19 infection. In about one month India, the world’s largest manufacturer, delivered hydroxychloroquine for treating COVID-19 to over 50 countries. The therapy is being used across the world both for patients staying at home at the early phase of symptoms, as well as for patients hospitalized. We summarize achievements as of late April 2020, review possible modes of action and suggest avenues for the quick scale-up of production of hydroxychloroquine.

The New Terrain of International Law

2014 ◽  
Author(s):  
Karen J. Alter
Keyword(s):  
International Law ◽  
Case Studies ◽  
Domestic Politics ◽  
Political Influence ◽  
The Political ◽  
International Courts ◽  
Constitutional Review ◽  
Delegation Of Authority ◽  
The World ◽  
The Law

In 1989, when the Cold War ended, there were six permanent international courts. Today there are more than two dozen that have collectively issued over thirty-seven thousand binding legal rulings. This book charts the developments and trends in the creation and role of international courts, and explains how the delegation of authority to international judicial institutions influences global and domestic politics. The book presents an in-depth look at the scope and powers of international courts operating around the world. Focusing on dispute resolution, enforcement, administrative review, and constitutional review, the book argues that international courts alter politics by providing legal, symbolic, and leverage resources that shift the political balance in favor of domestic and international actors who prefer policies more consistent with international law objectives. International courts name violations of the law and perhaps specify remedies. The book explains how this limited power—the power to speak the law—translates into political influence, and it considers eighteen case studies, showing how international courts change state behavior. The case studies, spanning issue areas and regions of the world, collectively elucidate the political factors that often intervene to limit whether or not international courts are invoked and whether international judges dare to demand significant changes in state practices.

The Role of Music and Allied Arts in Public Writings on Cultural Diversity: “People of Sri Lanka”

2020 ◽  
Vol 6 ◽  
pp. 93-100
Author(s):  
Gisa Jähnichen
Keyword(s):  
Sri Lanka ◽  
Cultural Diversity ◽  
South Asia ◽  
Case Studies ◽  
Sri Lankan ◽  
Culturally Different ◽  
The World ◽  
Official Languages ◽  
The Way

The Sri Lankan Ministry of National Coexistence, Dialogue, and Official Languages published the work “People of Sri Lanka” in 2017. In this comprehensive publication, 21 invited Sri Lankan scholars introduced 19 different people’s groups to public readers in English, mainly targeted at a growing number of foreign visitors in need of understanding the cultural diversity Sri Lanka has to offer. This paper will observe the presentation of these different groups of people, the role music and allied arts play in this context. Considering the non-scholarly design of the publication, a discussion of the role of music and allied arts has to be supplemented through additional analyses based on sources mentioned by the 21 participating scholars and their fragmented application of available knowledge. In result, this paper might help improve the way facts about groups of people, the way of grouping people, and the way of presenting these groupings are displayed to the world beyond South Asia. This fieldwork and literature guided investigation should also lead to suggestions for ethical principles in teaching and presenting of culturally different music practices within Sri Lanka, thus adding an example for other case studies.

Mikael Males, ed., Etymology and Wordplay in Medieval Literature. Disputatio, 30. Turnhout, Belgium: Brepols Publishers n.v., 2018, 272 pp., 10 ill.

Mediaevistik ◽  
2020 ◽  
Vol 32 (1) ◽  
pp. 320-322
Author(s):  
Robert E. Bjork
Keyword(s):  
Case Studies ◽  
Middle Ages ◽  
Medieval Literature ◽  
The World

During the logocentric Middle Ages, etymology and wordplay helped exegetes, philosophers, theologians, and poets understand the world and the world’s relationship to the divine. The case studies presented in this useful and fascinating collection of essays demonstrate how.

Is International Law International?

2017 ◽  
Author(s):  
Anthea Roberts ◽  
Martti Koskenniemi
Keyword(s):  
South China Sea ◽  
International Law ◽  
Case Studies ◽  
South China ◽  
Visual Representations ◽  
International Lawyer ◽  
Spheres Of Influence ◽  
Diverse Backgrounds ◽  
The World ◽  
Anglo American

Is International Law International? takes the reader on a sweeping tour of the international legal academy to reveal some of the patterns of difference, dominance, and disruption that belie international law’s claim to universality. Both revealing and challenging, confronting and engaging, this book is a must-read for any international lawyer, particularly in a world of shifting geopolitical power. Pulling back the curtain on the “divisible college of international lawyers,” the author shows how international lawyers in different states, regions, and geopolitical groupings are often subject to differences in their incoming influences and outgoing spheres of influence in ways that affect how they understand and approach international law, including with respect to contemporary controversies like Crimea and the South China Sea. Using case studies and visual representations, the author demonstrates how actors and materials from some states and groups have come to dominate certain transnational flows and forums in ways that make them disproportionately influential in constructing the “international”—a point which holds true for Western actors, materials, and approaches in general, and Anglo-American ones in particular. But these patterns are set for disruption. As the world moves past an era of Western dominance and toward greater multipolarity, it is imperative for international lawyers to understand the perspectives of those coming from diverse backgrounds. By taking readers on a comparative tour of different international law academies and textbooks, the author encourages international lawyers to see the world through others’ eyes—an approach that is pressing in a world of rising nationalism.

Introduction: The Translation History of Virgil

2018 ◽  
Author(s):  
Susanna Braund ◽  
Zara Martirosova Torlone
Keyword(s):  
Case Studies ◽  
Large Collection ◽  
The World ◽  
History Of ◽  
The Individual

The introduction describes the broad landscape of translation of Virgil from both the theoretical and the practical perspectives. It then explains the genesis of the volume and indicates how the individual chapters, each one of which is summarized, fit into the complex tapestry of Virgilian translation activity through the centuries and across the world. The volume editors indicate points of connection between the chapters in order to render the whole greater than the sum of its parts. Braund and Torlone emphasize that a project such as this could look like a (rather large) collection of case studies; they therefore consider it important to extrapolate larger phenomena from the specifics presented here

Introduction

2018 ◽  
Author(s):  
Tina K. Ramnarine
Keyword(s):  
Case Studies ◽  
Fundamental Question ◽  
Social Agency ◽  
Comparative Approach ◽  
Global Perspectives ◽  
Collective Creativity ◽  
Ensemble Performance ◽  
The World

This Introduction outlines various examples of ensemble performance to highlight diverse practices in the world of orchestras. It poses a fundamental question: What is an orchestra? It raises issues around collective creativity and social agency, which provide thematic foci in relation to a diversity of orchestral practices. Discussion on the conceptual aspects of adopting global perspectives on orchestras highlights comparison as a mode of theorization. The relevance of a comparative approach lies in its capacity to draw together diverse ethnographic case-studies. The Introduction thus provides a framework for reading this volume and it points out some of the conceptual connections between its chapters.

scholarly journals Handrails through the Swamp? A Pilot to Test the Integration and Implementation Science Framework in Complex Real-World Research

2021 ◽  
Vol 13 (10) ◽  
pp. 5491
Author(s):  
Melissa Robson-Williams ◽  
Bruce Small ◽  
Roger Robson-Williams ◽  
Nick Kirk
Keyword(s):  
Pilot Study ◽  
Case Studies ◽  
Implementation Science ◽  
Real World ◽  
Environmental Problems ◽  
Environmental Research ◽  
Integrative Framework ◽  
The World ◽  
Science Framework ◽  
Real World Problems

The socio-environmental challenges the world faces are ‘swamps’: situations that are messy, complex, and uncertain. The aim of this paper is to help disciplinary scientists navigate these swamps. To achieve this, the paper evaluates an integrative framework designed for researching complex real-world problems, the Integration and Implementation Science (i2S) framework. As a pilot study, we examine seven inter and transdisciplinary agri-environmental case studies against the concepts presented in the i2S framework, and we hypothesise that considering concepts in the i2S framework during the planning and delivery of agri-environmental research will increase the usefulness of the research for next users. We found that for the types of complex, real-world research done in the case studies, increasing attention to the i2S dimensions correlated with increased usefulness for the end users. We conclude that using the i2S framework could provide handrails for researchers, to help them navigate the swamps when engaging with the complexity of socio-environmental problems.

A Pandemic of Violence? The Impact of COVID-19 on Conflict

2020 ◽  
Vol 26 (3) ◽  
Author(s):  
Sara M.T. Polo
Keyword(s):  
Spatial Distribution ◽  
Real Time ◽  
Case Studies ◽  
Armed Conflict ◽  
Event Data ◽  
Social Unrest ◽  
Johns Hopkins University ◽  
The World ◽  
Political Advantage ◽  
The Impact

AbstractThis article examines the impact and repercussions of the COVID-19 pandemic on patterns of armed conflict around the world. It argues that there are two main ways in which the pandemic is likely to fuel, rather than mitigate, conflict and engender further violence in conflict-prone countries: (1) the exacerbating effect of COVID-19 on the underlying root causes of conflict and (2) the exploitation of the crisis by governments and non-state actors who have used the coronavirus to gain political advantage and territorial control. The article uses data collected in real-time by the Armed Conflict Location & Event Data Project (ACLED) and the Johns Hopkins University to illustrate the unfolding and spatial distribution of conflict events before and during the pandemic and combine this with three brief case studies of Afghanistan, Nigeria, and Libya. Descriptive evidence shows how levels of violence have remained unabated or even escalated during the first five months of the pandemic and how COVID-19-related social unrest has spread beyond conflict-affected countries.

Mounting Works on Paper with Neodymium Magnets

2014 ◽  
Vol 35 (3-4) ◽  
Author(s):  
Martina Noehles ◽  
Lena Niehus
Keyword(s):  
Physical Properties ◽  
Case Studies ◽  
Original Work ◽  
Traditional Methods ◽  
Valuable Addition ◽  
Works Of Art ◽  
Successful Case ◽  
Precautionary Measures ◽  
Neodymium Magnets

AbstractNeodymium magnets have been in use as a mounting technique for works of art on paper for several years; however, the method is still in its infancy. These very strong magnets provide a valuable addition to the traditional methods of mounting artworks on paper and objects made from paper, textile, or other materials for exhibitions. They offer an interesting and elegant alternative to attachment with adhesives, especially when adhesives may not or cannot be applied to the original work. This article addresses the physical properties and manufacture of the magnets, including their coatings and nomenclature. Three successful case studies of mounting artworks on paper with these “super magnets” are presented here. In addition, the limits and possible difficulties of working with neodymium magnets are addressed, as well as precautionary measures to take when handling them.

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