scholarly journals Magnetic field activated drug delivery using thermodegradable azo-functionalised PEG-coated core–shell mesoporous silica nanoparticles

Nanoscale ◽  
2015 ◽  
Vol 7 (31) ◽  
pp. 13168-13172 ◽  
Author(s):  
P. Saint-Cricq ◽  
S. Deshayes ◽  
J. I. Zink ◽  
A. M. Kasko
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Core Shell

A NIR light-triggered drug delivery system using core–shell gold nanostars–mesoporous silica nanoparticles based on multiphoton absorption photo-dissociation of 2-nitrobenzyl PEG

2019 ◽  
Vol 55 (61) ◽  
pp. 9039-9042 ◽  
Author(s):  
Andy Hernández-Montoto ◽  
Mónica Gorbe ◽  
Antoni Llopis-Lorente ◽  
José Manuel Terrés ◽  
Roberto Montes ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Shell ◽  
Multiphoton Absorption ◽  
Core Shell ◽  
Gold Nanostars ◽  
Nir Light

Gold nanostars coated with a mesoporous silica shell and functionalised with PEG containing photolabile 2-nitrobenzyl moieties released doxorubicin after NIR light irradiation.

Magnetic Field-Induced Accentuation of Drug Release from Core/Shell Magnetic Mesoporous Silica Nanoparticles for Anticancer Treatment

2016 ◽  
Vol 16 (4) ◽  
pp. 4195-4199 ◽  
Author(s):  
Nikola Ž Knežević
Keyword(s):  
Magnetic Field ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Hela Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers ◽  
Core Shell ◽  
Delivery Method ◽  
Anticancer Treatment ◽  
Magnetic Mesoporous Silica

Drug (9-aminoacridine) loaded core/shell magnetic iron oxide-containing mesoporous silica nanoparticles (MMSN) were treated with HeLa cells and the drug carriers were agitated by exposure to magnetic field. Viability studies show the applicability of drug loaded magnetic material for anticancer treatment, which is enhanced upon stimulation with magnetic field. Confocal micrographs of fluorescein grafted MMSN-treated HeLa cells confirmed the ability of magnetic field to concentrate the synthesized material in the exposed area of the cells. The synthesized material and the applied drug delivery method may find application in magnetic field-responsive targeted treatment of cancer.

Construction of polymer coated core–shell magnetic mesoporous silica nanoparticles with triple responsive drug delivery

2017 ◽  
Vol 8 (38) ◽  
pp. 5852-5864 ◽  
Author(s):  
Mohammad Hegazy ◽  
Pei Zhou ◽  
Guangyu Wu ◽  
Lei Wang ◽  
Nahla Rahoui ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Delivery Systems ◽  
Core Shell ◽  
On Demand ◽  
Magnetic Mesoporous Silica

Multi-responsive drug delivery systems are playing a very important role in nanomedicine, as they can feature as smart carriers releasing their payload on demand.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

In Vitro Evaluation of pH Responsive Doxazosin Loaded Mesoporous Silica Nanoparticles: A Smart Approach in Drug Delivery

2016 ◽  
Vol 13 (4) ◽  
pp. 574-581 ◽  
Author(s):  
Arijit Guha ◽  
Nikhil Biswas ◽  
Kaustav Bhattacharjee ◽  
Piu Das ◽  
Ketousetuo Kuotsu
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Responsive ◽  
In Vitro Evaluation
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