A highly enantioselective Hg(ii)-catalyzed Sakurai–Hosomi reaction of isatins with allyltrimethylsilanes

2016 ◽  
Vol 14 (24) ◽  
pp. 5500-5504 ◽  
Author(s):  
Zhong-Yan Cao ◽  
Jia-Sheng Jiang ◽  
Jian Zhou
Keyword(s):  
Building Blocks ◽  
Catalyst Loading ◽  
Facile Synthesis ◽  
Chiral Complex

A chiral complex derived from (S)-difluorophos and Hg(OTf)2 is identified as a powerful catalyst for the Sakurai–Hosomi reaction of isatins with allyltrimethylsilane, allowing the facile synthesis of valuable building blocks 3-allyl-3-hydroxyoxindoles in up to 97% ee, with only 0.5–1.0 mol% of catalyst loading.

Y(OTf)3-catalyzed Phosphorylation of 2H-Chromene Hemiacetals with P(O)-H compounds to 2-Phosphorylated 2H-Chromenes

2021 ◽  
Author(s):  
Long Chen ◽  
Shi-Lu Zheng ◽  
Yun-Xiang Zou ◽  
Zhong Wen ◽  
Jiafu Lin ◽  
...  
Keyword(s):  
Catalyst Loading ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
Low Catalyst Loading

Facile synthesis of 2-phosphorylated 2H-chromenes has been accomplished herein via a Y(OTf)3-catalyzed dehydrative coupling of 2H-chromene hemiacetals with P(O)-H compounds. This protocol features low catalyst loading, mild reaction conditions, broad...

scholarly journals A Facile Synthesis of α-N-Ribosyl-Asparagine and α-N-Ribosyl-Glutamine Building Blocks

Molecules ◽  
2013 ◽  
Vol 18 (8) ◽  
pp. 8779-8785 ◽  
Author(s):  
Gaetano Speciale ◽  
Anna Bernardi ◽  
Filippo Nisic
Keyword(s):  
Building Blocks ◽  
Facile Synthesis

Facile Synthesis of Guanidine Functionalised Building Blocks

2015 ◽  
Vol 4 (4) ◽  
pp. 320-326 ◽  
Author(s):  
Shane M. Hickey ◽  
Trent D. Ashton ◽  
Frederick M. Pfeffer
Keyword(s):  
Building Blocks ◽  
Facile Synthesis

Facile Synthesis of α-Functionalized Vinyl Sulfides Bearing β-Trifluoromethyl Group: Highly Potential CF3-Containing Building Blocks.

ChemInform ◽  
2007 ◽  
Vol 38 (36) ◽  
Author(s):  
Takeshi Hanamoto ◽  
Ryoko Anno ◽  
Kenji Yamada ◽  
Kousuke Ryu
Keyword(s):  
Building Blocks ◽  
Trifluoromethyl Group ◽  
Facile Synthesis ◽  
Vinyl Sulfides

Facile synthesis of α-functionalized vinyl sulfides bearing β-trifluoromethyl group: a highly potential CF3-containing building blocks

2007 ◽  
Vol 48 (21) ◽  
pp. 3727-3730 ◽  
Author(s):  
Takeshi Hanamoto ◽  
Ryoko Anno ◽  
Kenji Yamada ◽  
Kousuke Ryu
Keyword(s):  
Building Blocks ◽  
Trifluoromethyl Group ◽  
Facile Synthesis ◽  
Vinyl Sulfides ◽  
Group A

scholarly journals Facile synthesis of N-doped graphene encapsulated Pd@N/C catalyst and its efficient application in cascade flow synthesis of amines

2021 ◽  
Author(s):  
Jianguo Liu ◽  
Jiangmin Sun ◽  
Yanpei Song ◽  
Shanshan Lin ◽  
Longlong Ma
Keyword(s):  
Heterogeneous Catalyst ◽  
Primary Amine ◽  
Flow Reactor ◽  
Building Blocks ◽  
Primary Amines ◽  
Facile Synthesis ◽  
Flow Synthesis ◽  
Nitrogen Doped ◽  
Doped Graphene ◽  
Excellent Stability

Abstract N-methylamines, as an important class of chemicals, crucial building blocks, have been widely used in pharmaceutical companies and materials synthesis. Transition metal-catalyzed synthesis of N-methylamines, especially the heterogeneous catalyzed N-methylation of amines via different C1 sources has become the most promising methodology, due to the environmentally friendlier process and the recyclable and easily accessible catalysts. However, these reactions generally require activated toxic methyl iodide or dimethyl sulfoxide, and homogeneous catalysts or Raney nickel catalyst. The synthesis of amines still suffering from narrow scopes of amines, harsh reaction conditions, low selectivity of the desired products, and against the requirements of atomic economy and sustainable green environment. Herein, we developed a novel facile synthesis of nitrogen-doped graphene encapsulated Pd@NC nanocatalysts. The resulting heterogeneous catalyst was active for the synthesis of amines (more than 83 examples, yield up to 99%). The nitrogen-doped effect was unlike the previous report that poisoned the metal, it could increase the interaction with the active metal resulting in excellent stability. As far as we know, for the first time, the developed N-doped graphene encapsulated Pd@NC nanocatalyst showed excellent stability and activity of amines synthesis in the 20 times’ recycling test, industrially applicable flow reactor 2880 minutes’ test, and 99% purity of primary amine and tertiary amines product preparation test. Moreover, we have also shown the high atomic economy and environmentally friendlier tandem flow synthesis of N, N-dimethylamine products via the combination of reduction of nitrobenzene and N-methylation of amines, using the single one Pd@NC nanocatalyst with H2O as the only by-product. Upon our knowledge, this is a novel example of primary amine and tertiary amine synthesis methodology with the combined cascade reaction and flow process of nitrobenzene reduction and primary amines N-methylation with a single heterogeneous catalyst.

scholarly journals Asymmetric Michael Addition of Malononitrile with Chalcones via Rosin-Derived Bifunctional Squaramide

Catalysts ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 14
Author(s):  
Ning Lin ◽  
Qiu-Xiang Wei ◽  
Li-Hua Jiang ◽  
Yan-Qiu Deng ◽  
Zhen-Wei Zhang ◽  
...  
Keyword(s):  
Michael Addition ◽  
Carbonyl Compounds ◽  
Catalyst Loading ◽  
Facile Synthesis ◽  
Asymmetric Michael Addition ◽  
High Yields ◽  
Experimental Findings

A rosin-derived bifunctional squaramide catalyzed asymmetric Michael addition of malononitrile with chalcones was discovered. This protocol provides a methodology for the facile synthesis of chiral γ-cyano carbonyl compounds in high yields and enantioselectivities (up to 99% yield and 90% ee) with a lower catalyst loading (0.3 mol%). The predominant R-configured adducts were obtained by this organocatalystic reaction, according to the experimental findings.

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