Novel, fast-processed crystalline and amorphous manganese oxide nanoparticles for stem cell labeling

2015 ◽  
Vol 2 (7) ◽  
pp. 640-648 ◽  
Author(s):  
Jessica M. Rosenholm ◽  
Riikka M. Korpi ◽  
Eveliina Lammentausta ◽  
Siri Lehtonen ◽  
Petri Lehenkari ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mr Imaging ◽  
Contrast Agents ◽  
Manganese Oxide ◽  
Cell Labeling ◽  
Oxide Nanoparticles ◽  
Manganese Oxide Nanoparticles ◽  
Cellular Labeling ◽  
Amorphous Manganese Oxide

MnO(x) nanostructures were developed to be utilized as contrast agents for cellular labeling and tracking by MR-imaging.

MnO2 nanoflowers as a multifunctional nano-platform for enhanced photothermal/photodynamic therapy and MR imaging

2021 ◽  
Author(s):  
Wanru Sun ◽  
Hui Yu ◽  
Deqiang Wang ◽  
Youjie Li ◽  
Baocheng Tian ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mr Imaging ◽  
Manganese Oxide ◽  
Oxide Nanoparticles ◽  
Manganese Oxide Nanoparticles

Well-defined flower-shaped manganese oxide nanoparticles modified with 3-aminopropyltriethoxysilane (APTES) and loaded with Ce6 were achieved to realize synergistic PDT/PTT therapy and MR imaging.

scholarly journals Mesenchymal Stem Cells Do Not Lose Direct Labels Including Iron Oxide Nanoparticles and DFO-89Zr Chelates through Secretion of Extracellular Vesicles

Membranes ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 484
Author(s):  
Yue Gao ◽  
Anna Jablonska ◽  
Chengyan Chu ◽  
Piotr Walczak ◽  
Miroslaw Janowski
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Extracellular Vesicles ◽  
Superparamagnetic Iron Oxide ◽  
Cell Labeling ◽  
Oxide Nanoparticles ◽  
Stem Cell Delivery ◽  
Cellular Labeling

Rapidly ageing populations are beset by tissue wear and damage. Stem cell-based regenerative medicine is considered a solution. Years of research point to two important aspects: (1) the use of cellular imaging to achieve sufficient precision of therapeutic intervention, and the fact that (2) many therapeutic actions are executed through extracellular vesicles (EV), released by stem cells. Therefore, there is an urgent need to interrogate cellular labels in the context of EV release. We studied clinically applicable cellular labels: superparamagnetic iron oxide nanoparticles (SPION), and radionuclide detectable by two main imaging modalities: MRI and PET. We have demonstrated effective stem cell labeling using both labels. Then, we obtained EVs from cell cultures and tested for the presence of cellular labels. We did not find either magnetic or radioactive labels in EVs. Therefore, we report that stem cells do not lose labels in released EVs, which indicates the reliability of stem cell magnetic and radioactive labeling, and that there is no interference of labels with EV content. In conclusion, we observed that direct cellular labeling seems to be an attractive approach to monitoring stem cell delivery, and that, importantly, labels neither locate in EVs nor affect their basic properties.

scholarly journals L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles

Small ◽  
2015 ◽  
Vol 12 (3) ◽  
pp. 301-306 ◽  
Author(s):  
Birgitte Hjelmeland McDonagh ◽  
Gurvinder Singh ◽  
Sjoerd Hak ◽  
Sulalit Bandyopadhyay ◽  
Ingrid Lovise Augestad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Contrast Agents ◽  
Manganese Oxide ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Manganese Oxide Nanoparticles ◽  
Mri Contrast ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy

2019 ◽  
Vol Volume 14 ◽  
pp. 8321-8344 ◽  
Author(s):  
Xiaoxia Cai ◽  
Qingxia Zhu ◽  
Yun Zeng ◽  
Qi Zeng ◽  
Xueli Chen ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Manganese Oxide ◽  
Multimodal Imaging ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Manganese Oxide Nanoparticles ◽  
Mri Contrast
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