Hydrophilic interaction chromatography-tandem mass spectrometry based on an amide column for the high-throughput quantification of metformin in rat plasma

RSC Advances ◽  
2015 ◽  
Vol 5 (123) ◽  
pp. 101386-101392 ◽  
Author(s):  
Rong Shi ◽  
Xining Xu ◽  
Jiasheng Wu ◽  
Tianming Wang ◽  
Yuanyuan Li ◽  
...  

A simple, highly sensitive, specific, reproducible, and high-throughput Amide-HILIC-MS/MS assay to quantify metformin in rat plasma was established and successfully applied for sample analysis to support pharmacokinetic studies.

Sign in / Sign up

Export Citation Format

Share Document