In-depth study on the gene silencing capability of silica nanoparticles with different pore sizes: degree and duration of RNA interference

RSC Advances ◽  
2016 ◽  
Vol 6 (32) ◽  
pp. 27143-27150 ◽  
Author(s):  
Seongchan Kim ◽  
Hee-Kyung Na ◽  
Cheolhee Won ◽  
Dal-Hee Min
Keyword(s):  
Rna Interference ◽  
Mesoporous Silica ◽  
Gene Silencing ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sirna Delivery ◽  
Pore Sizes ◽  
Depth Study ◽  
Kinetics Of ◽  
Sirna Delivery System

The mesoporous silica nanoparticles (MSN) having different pore sizes were synthesized and utilized for siRNA delivery system capable of controlling kinetics of RNA interference.

scholarly journals Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted siRNA Delivery to HER2+Breast Cancer

2015 ◽  
Vol 25 (18) ◽  
pp. 2646-2659 ◽  
Author(s):  
Worapol Ngamcherdtrakul ◽  
Jingga Morry ◽  
Shenda Gu ◽  
David J. Castro ◽  
Shaun M. Goodyear ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sirna Delivery ◽  
Cationic Polymer ◽  
Her2 Breast Cancer

scholarly journals Characterization of modified mesoporous silica nanoparticles as vectors for siRNA delivery

2018 ◽  
Vol 13 (6) ◽  
pp. 592-599 ◽  
Author(s):  
Anna Slita ◽  
Anna Egorova ◽  
Eudald Casals ◽  
Anton Kiselev ◽  
Jessica M. Rosenholm
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sirna Delivery

scholarly journals Effects of pore size on in vitro and in vivo anticancer efficacies of mesoporous silica nanoparticles

RSC Advances ◽  
2018 ◽  
Vol 8 (43) ◽  
pp. 24633-24640 ◽  
Author(s):  
Jie Li ◽  
Suqin Shen ◽  
Fei Kong ◽  
Ting Jiang ◽  
Cui Tang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Pore Size ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Pore Sizes

MSN with suitable pore sizes achieved an outstanding performance for in vitro and in vivo antitumor efficacies.

scholarly journals Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 742 ◽  
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Drug Delivery Vehicles ◽  
Biological Compatibility ◽  
Delivery Vehicles ◽  
Efficient Loading ◽  
Kinetics Of

The fruition, commercialisation and clinical application combining nano-engineering, nanomedicine and material science for utilisation in drug delivery is becoming a reality. The successful integration of nanomaterial in nanotherapeutics requires their critical development to ensure physiological and biological compatibility. Mesoporous silica nanoparticles (MSNs) are attractive nanocarriers due to their biodegradable, biocompatible, and relative malleable porous frameworks that can be functionalized for enhanced targeting and delivery in a variety of disease models. The optimal formulation of an MSN with polyethylene glycol (2% and 5%) and chitosan was undertaken, to produce sterically stabilized, hydrophilic MSNs, capable of efficient loading and delivery of the hydrophobic anti-neoplastic drug, doxorubicin (DOX). The pH-sensitive release kinetics of DOX, together with the anticancer, apoptosis and cell-cycle activities of DOX-loaded MSNs in selected cancer cell lines were evaluated. MSNs of 36–60 nm in size, with a pore diameter of 9.8 nm, and a cumulative surface area of 710.36 m2/g were produced. The 2% pegylated MSN formulation (PCMSN) had the highest DOX loading capacity (0.98 mgdox/mgmsn), and a sustained release profile over 72 h. Pegylated-drug nanoconjugates were effective at a concentration range between 20–50 μg/mL, inducing apoptosis in cancer cells, and affirming their potential as effective drug delivery vehicles.

Comparative release kinetics of small drugs (ibuprofen and acetaminophen) from multifunctional mesoporous silica nanoparticles

2020 ◽  
Vol 8 (10) ◽  
pp. 2096-2106 ◽  
Author(s):  
Eun-Bi Lim ◽  
Tran Anh Vy ◽  
Sang-Wha Lee
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Intermolecular Interactions ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Kinetics Of

Multifunctional mesoporous silica nanoparticles (MSNs) can confer dynamically varied release kinetics depending on the intermolecular interactions between model drugs and functional decorations on the MSNs.

Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles

Nanoscale ◽  
2017 ◽  
Vol 9 (16) ◽  
pp. 5329-5341 ◽  
Author(s):  
Jianliang Shen ◽  
Haoran Liu ◽  
Chaofeng Mu ◽  
Joy Wolfram ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Gene Silencing ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica

Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids

2016 ◽  
Vol 79 (2) ◽  
pp. 319-327 ◽  
Author(s):  
Katharina Braun ◽  
Alexander Pochert ◽  
Michaela Beck ◽  
Richard Fiedler ◽  
Jens Gruber ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Dissolution Kinetics ◽  
Body Fluids ◽  
Simulated Body Fluids ◽  
Kinetics Of
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