Single component thermo-gelling electroactive hydrogels from poly(caprolactone)–poly(ethylene glycol)–poly(caprolactone)-graft-aniline tetramer amphiphilic copolymers

2015 ◽  
Vol 3 (43) ◽  
pp. 8459-8468 ◽  
Author(s):  
Xin Zhao ◽  
Baolin Guo ◽  
Peter X. Ma
Keyword(s):  
Ethylene Glycol ◽  
Single Component ◽  
Amphiphilic Copolymers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Conductive Hydrogels ◽  
Poly Caprolactone

Single component injectable degradable conductive hydrogels with excellent biocompatibility based on poly(caprolactone)–poly(ethylene glycol)–poly(caprolactone) and aniline tetramer were prepared via a thermo-gelling approach.

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1438
Author(s):  
Silvio Curia ◽  
Feifei Ng ◽  
Marie-Emérentienne Cagnon ◽  
Victor Nicoulin ◽  
Adolfo Lopez-Noriega
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Gel Chromatography ◽  
Amphiphilic Copolymers ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Acting ◽  
In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation.

Preparation of poly(ethylene glycol)-block-poly(caprolactone) copolymers and their applications as thermo-sensitive materials

2004 ◽  
Vol 70A (1) ◽  
pp. 154-158 ◽  
Author(s):  
Moon Suk Kim ◽  
Kwang Su Seo ◽  
Gilson Khang ◽  
Sun Hang Cho ◽  
Hai Bang Lee
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Poly Caprolactone
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