Ligand non-innocence and strong correlation in manganese superoxide dismutase mimics

2017 ◽  
Vol 19 (6) ◽  
pp. 4656-4660 ◽  
Author(s):  
Alexandra R. McIsaac ◽  
David A. Mazziotti
Keyword(s):  
Superoxide Dismutase ◽  
Electron Correlation ◽  
Strong Correlation ◽  
Manganese Superoxide Dismutase ◽  
Critical Role ◽  
Strong Electron Correlation ◽  
Strong Electron ◽  
Manganese Superoxide ◽  
Superoxide Dismutase Mimics

Strong electron correlation plays a critical role in the reduction of manganese superoxide dismutase mimics, stabilizing a ligand-centered reduction.

Regulation of lung manganese superoxide dismutase: species variation in response to lipopolysaccharide

1999 ◽  
Vol 276 (5) ◽  
pp. L705-L708 ◽  
Author(s):  
Ghenima Dirami ◽  
Donald Massaro ◽  
Linda Biadasz Clerch
Keyword(s):  
Superoxide Dismutase ◽  
Manganese Superoxide Dismutase ◽  
Critical Role ◽  
Mouse Lung ◽  
Translational Efficiency ◽  
Species Variation ◽  
Sod Activity ◽  
Mrna Concentration ◽  
Manganese Superoxide ◽  
Lps Treatment

Lipopolysaccharide (LPS) treatment increases survival of rats, but not of mice, during hyperoxia. Manganese superoxide dismutase (Mn SOD) in the lung plays a critical role in LPS-induced tolerance to hyperoxia in rats. Therefore, we now compared the response of lung Mn SOD with treatment of mice and rats with LPS. LPS treatment of rats increased Mn SOD activity and protein concentration, did not change its specific activity, increased Mn SOD mRNA concentration 35-fold, and elevated Mn SOD synthesis 50% without changing general protein synthesis. LPS treatment of mice did not alter any of these parameters except for a 16-fold increase in Mn SOD mRNA concentration. Mn SOD translational efficiency (synthesis/mRNA concentration) was diminished 93% in rat lung and 76% in mouse lung by treatment with LPS. However, the absolute translational efficiency was twofold higher in lungs of LPS-treated rats than in lungs of LPS-treated mice. The failure of LPS to raise Mn SOD activity in mouse lungs is due, at least in part, to a smaller increase in Mn SOD mRNA and lower translational efficiency in LPS-treated mice than in LPS-treated rats.

Monomeric (benzoato)manganese(II) complexes as manganese superoxide dismutase mimics

1993 ◽  
Vol 32 (10) ◽  
pp. 1879-1880 ◽  
Author(s):  
Nobumasa Kitajima ◽  
Masahisa Osawa ◽  
Nobuchika Tamura ◽  
Yoshihiko Morooka ◽  
Tomohisa Hirano ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Manganese Superoxide Dismutase ◽  
Manganese Superoxide ◽  
Superoxide Dismutase Mimics
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