Silica/organosilica cross-linked block copolymer micelles: a versatile theranostic platform

2017 ◽  
Vol 46 (3) ◽  
pp. 569-585 ◽  
Author(s):  
Dechao Niu ◽  
Yongsheng Li ◽  
Jianlin Shi
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Hybrid Materials ◽  
Biomedical Applications ◽  
Recent Progress ◽  
Amphiphilic Block Copolymers ◽  
Cross Linking ◽  
Design Synthesis ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Silica/organosilica cross-linked block copolymer micelles are a novel class of hybrid materials that combine the advantages of amphiphilic block copolymers and silica/organosilica cross-linking agents into one unit. This Tutorial Review summarizes the recent progress in the design, synthesis and biomedical applications of various silica/organosilica cross-linked block copolymer micelles.

scholarly journals Characterizing block-copolymer micelles used in nanomedicines via solution static scattering techniques

2021 ◽  
Author(s):  
Isamu Akiba ◽  
Kazuo Sakurai
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Static Solution ◽  
Theoretical Background ◽  
Hydrophobic Drugs ◽  
Safety And Efficacy ◽  
Critical Quality Attributes ◽  
Regulatory Authorities ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

AbstractBlock copolymers are well recognized as excellent nanotools for delivering hydrophobic drugs. The formulation of such delivery nanoparticles requires robust characterization and clarification of the critical quality attributes correlating with the safety and efficacy of the drug before applying to regulatory authorities for approval. Static solution scattering from block copolymers is one such technique. This paper first outlines the theoretical background and current models for analyzing this scattering and then presents an overview of our recent studies on block copolymers.

Cross-Linking of Cationic Block Copolymer Micelles by Silica Deposition

2007 ◽  
Vol 129 (6) ◽  
pp. 1717-1723 ◽  
Author(s):  
Jian-Jun Yuan ◽  
Oleksandr O. Mykhaylyk ◽  
Anthony J. Ryan ◽  
Steven P. Armes
Keyword(s):  
Block Copolymer ◽  
Cross Linking ◽  
Silica Deposition ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

scholarly journals A facile strategy for manipulating micellar size and morphology through intramolecular cross-linking of amphiphilic block copolymers

2017 ◽  
Vol 8 (23) ◽  
pp. 3647-3656 ◽  
Author(s):  
Ryoto Tanaka ◽  
Kodai Watanabe ◽  
Takuya Yamamoto ◽  
Kenji Tajima ◽  
Takuya Isono ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Self Assembly ◽  
Amphiphilic Block Copolymers ◽  
Amphiphilic Block Copolymer ◽  
Cross Linking ◽  
Micellar Size ◽  
System P ◽  
Assembly Behavior ◽  
Size And Morphology

The effect of intramolecular cross-linking on aqueous self-assembly behavior was systematically investigated based on an amphiphilic block copolymer system.

Rodlike Block Copolymer Micelles of Controlled Length in Water Designed for Biomedical Applications

2019 ◽  
Vol 52 (14) ◽  
pp. 5231-5244 ◽  
Author(s):  
Qing Yu ◽  
Megan G. Roberts ◽  
Samuel Pearce ◽  
Alex M. Oliver ◽  
Hang Zhou ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Biomedical Applications ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Aggregation-induced emission from the crowded coronal chains of block copolymer micelles

2020 ◽  
Vol 11 (29) ◽  
pp. 4706-4713 ◽  
Author(s):  
Siyu Wang ◽  
Bixin Jin ◽  
Gangfeng Chen ◽  
Yunjun Luo ◽  
Xiaoyu Li
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Self Assembly ◽  
The Self ◽  
Assembly Process ◽  
Spatial Confinement ◽  
Aggregation Induced Emission ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Aggregation-induced emission (AIE) was triggered via the spatial confinement in the coronal chains in block copolymers upon micellization, even with very low content of AIE groups attached, and this could be used to monitor the self-assembly process.

Superior proapoptotic activity of curcumin-loaded mixed block copolymer micelles with mitochondrial targeting properties

2018 ◽  
Vol 6 (12) ◽  
pp. 3309-3317 ◽  
Author(s):  
Denitsa Momekova ◽  
Iva Ugrinova ◽  
Marta Slavkova ◽  
Georgi Momekov ◽  
Georgy Grancharov ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Mixed Block ◽  
Mitochondrial Targeting ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Multifunctional micelles based on two co-assembled block copolymers are proven to effectively accumulate and deliver curcumin in mitochondria, thus, inducing a much higher proapoptotic activity than single copolymer micelles.

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