Anticancer activity of a chelating nitrogen mustard bearing tetrachloridoplatinum(iv) complex: better stability yet equipotent to the Pt(ii) analogue

A tetrachlorido Pt(iv) complex of a chelating nitrogen mustard (1a) shows higher solution stability than its known Pt(ii) counterpart yet is cytotoxic, shows GSH resistance and induces apoptosis.

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Chloroalkyl piperazine and nitrogen mustard porphyrins: synthesis and anticancer activity

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2004.01.045 ◽

2004 ◽

Vol 12 (9) ◽

pp. 2469-2475 ◽

Cited By ~ 60

Author(s):

Can-Cheng Guo ◽

Rong-Biao Tong ◽

Ke-Lai Li

Keyword(s):

Anticancer Activity ◽

Nitrogen Mustard

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Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation

Dalton Transactions ◽

10.1039/d0dt03465g ◽

2020 ◽

Vol 49 (46) ◽

pp. 16887-16902

Author(s):

Éva A. Enyedy ◽

Nóra V. May ◽

Veronika F. S. Pape ◽

Petra Heffeter ◽

Gergely Szakács ◽

...

Keyword(s):

Complex Formation ◽

Anticancer Activity ◽

Redox Properties ◽

Solution Stability ◽

Chalcogen Atom ◽

Solution Study

Effect of exchange of S to O or Se in Triapine and methylation of the hydrazone NH on the pKa, lipophilicity, solution stability and redox properties of Cu(ii), Fe(ii) and Fe(iii) complexes and their anticancer activity.

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The design, synthesis and anticancer activity of new nitrogen mustard derivatives of natural indole phytoalexin 1-methoxyspirobrassinol

Neoplasma ◽

10.4149/neo_2009_04_321 ◽

2009 ◽

Vol 56 (4) ◽

pp. 321-330 ◽

Cited By ~ 11

Author(s):

R. MEZENCEV ◽

P. KUTSCHY ◽

A. SALAYOVA ◽

T. UPDEGROVE ◽

J. McDONALD

Keyword(s):

Anticancer Activity ◽

Nitrogen Mustard ◽

Design Synthesis ◽

Derivatives Of

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Anticancer activity of a cis-dichloridoplatinum(ii) complex of a chelating nitrogen mustard: insight into unusual guanine binding mode and low deactivation by glutathione

Dalton Transactions ◽

10.1039/c5dt04459f ◽

2016 ◽

Vol 45 (8) ◽

pp. 3599-3615 ◽

Cited By ~ 15

Author(s):

Subhendu Karmakar ◽

Kallol Purkait ◽

Saptarshi Chatterjee ◽

Arindam Mukherjee

Keyword(s):

Anticancer Activity ◽

Nitrogen Mustard ◽

Binding Mode ◽

Angiogenic Potential ◽

Insight Into

A platinum(ii) complex (2) of a chelating nitrogen mustard shows potency against MIA PaCa2.2displays anti-angiogenic potential and displays excellent cytotoxicity profile even in presence of GSH in hypoxia.

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