Novel LC-MS/MS approaches for metabolite identification of natural compounds, such as curcumin and analogues, with anticancer activity

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
C Tamvakopoulos ◽  
ZD Sofianos ◽  
AL Skaltsounis ◽  
M Kritsanida
Keyword(s):  
Anticancer Activity ◽  
Metabolite Identification ◽  
Natural Compounds

scholarly journals Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies

Marine Drugs ◽  
2021 ◽  
Vol 19 (11) ◽  
pp. 610
Author(s):  
Junjie Yan ◽  
Weiwei Liu ◽  
Jiatong Cai ◽  
Yiming Wang ◽  
Dahong Li ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Pharmacological Activity ◽  
Biological Activities ◽  
Natural Compounds ◽  
Mechanisms Of Action ◽  
Biosynthetic Pathways ◽  
Pharmacological Activities ◽  
Chemical Structures ◽  
The Past ◽  
Synthetic Derivatives

Phenazines are a large group of nitrogen-containing heterocycles, providing diverse chemical structures and various biological activities. Natural phenazines are mainly isolated from marine and terrestrial microorganisms. So far, more than 100 different natural compounds and over 6000 synthetic derivatives have been found and investigated. Many phenazines show great pharmacological activity in various fields, such as antimicrobial, antiparasitic, neuroprotective, insecticidal, anti-inflammatory and anticancer activity. Researchers continued to investigate these compounds and hope to develop them as medicines. Cimmino et al. published a significant review about anticancer activity of phenazines, containing articles from 2000 to 2011. Here, we mainly summarize articles from 2012 to 2021. According to sources of compounds, phenazines were categorized into natural phenazines and synthetic phenazine derivatives in this review. Their pharmacological activities, mechanisms of action, biosynthetic pathways and synthetic strategies were summarized. These may provide guidance for the investigation on phenazines in the future.

Enhancing the Anticancer Activity and Selectivity of Goniothalamin Using pH-Sensitive Acetalated Dextran (Ac-Dex) Nanoparticles: A Promising Platform for Delivery of Natural Compounds

2020 ◽  
Vol 6 (5) ◽  
pp. 2929-2942
Author(s):  
Carolyne B. Braga ◽  
Larissa A. Kido ◽  
Ellen N. Lima ◽  
Celina A. Lamas ◽  
Valéria H. A. Cagnon ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Natural Compounds ◽  
Ph Sensitive

scholarly journals Role of Endoplasmic Reticulum Stress in the Anticancer Activity of Natural Compounds

2019 ◽  
Vol 20 (4) ◽  
pp. 961 ◽  
Author(s):  
Patrizia Limonta ◽  
Roberta Moretti ◽  
Monica Marzagalli ◽  
Fabrizio Fontana ◽  
Michela Raimondi ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Anticancer Activity ◽  
Molecular Mechanisms ◽  
Natural Compounds ◽  
New Drugs ◽  
Bioactive Molecules ◽  
Green Tea Polyphenols ◽  
Cell Death Pathways ◽  
Incidence And Mortality

Cancer represents a serious global health problem, and its incidence and mortality are rapidly growing worldwide. One of the main causes of the failure of an anticancer treatment is the development of drug resistance by cancer cells. Therefore, it is necessary to develop new drugs characterized by better pharmacological and toxicological profiles. Natural compounds can represent an optimal collection of bioactive molecules. Many natural compounds have been proven to possess anticancer effects in different types of tumors, but often the molecular mechanisms associated with their cytotoxicity are not completely understood. The endoplasmic reticulum (ER) is an organelle involved in multiple cellular processes. Alteration of ER homeostasis and its appropriate functioning originates a cascade of signaling events known as ER stress response or unfolded protein response (UPR). The UPR pathways involve three different sensors (protein kinase RNA(PKR)-like ER kinase (PERK), inositol requiring enzyme1α (IRE1) and activating transcription factor 6 (ATF6)) residing on the ER membranes. Although the main purpose of UPR is to restore this organelle’s homeostasis, a persistent UPR can trigger cell death pathways such as apoptosis. There is a growing body of evidence showing that ER stress may play a role in the cytotoxicity of many natural compounds. In this review we present an overview of different plant-derived natural compounds, such as curcumin, resveratrol, green tea polyphenols, tocotrienols, and garcinia derivates, that exert their anticancer activity via ER stress modulation in different human cancers.

scholarly journals Lecithin–chitosan–TPGS nanoparticles as nanocarriers of (−)-epicatechin enhanced its anticancer activity in breast cancer cells

RSC Advances ◽  
2018 ◽  
Vol 8 (61) ◽  
pp. 34773-34782 ◽  
Author(s):  
Adriana Guadalupe Perez-Ruiz ◽  
Adriana Ganem ◽  
Ivonne María Olivares-Corichi ◽  
José Rubén García-Sánchez
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Natural Compounds ◽  
Biological Properties

Natural compounds such as (−)-epicatechin show a variety of biological properties including anticancer activity.

scholarly journals Anticancer Activity of Natural Compounds

2021 ◽  
Vol 22 (S1) ◽  
pp. 1-2
Author(s):  
Abdul Q Khan ◽  
Shahab Uddin
Keyword(s):  
Anticancer Activity ◽  
Natural Compounds

Sanguinarine: A Double-Edged Sword of Anticancer and Carcinogenesis and its Future Application Prospect

2021 ◽  
Vol 21 ◽  
Author(s):  
Guanhua Lou ◽  
Jin Wang ◽  
Ju Hu ◽  
Qingxia Gan ◽  
Chengyi Peng ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Natural Compounds ◽  
Future Application ◽  
Anticancer Effect ◽  
Clinical Investigations ◽  
Potential Development ◽  
The Future ◽  
Future Potential ◽  
Experimental Researches

Background: Sanguinarine, a kind of benzophenanthridine alkaloid, is a natural compounds with potential development value for its anticancer activity. Hundreds of studies have been carried out in vivo or vitro, trying to make it feasible for the anticancer clinic medication of sanguinarine. However, sanguinarine was branded a toxicant or even a carcinogen according to some toxicological experiments and cancer investigations. Objective: Aimming at safety and effectiveness of sanguinarine, this article reviews the extant information on present studies of sanguinarine, both anticancer are carcinogenesis mechanism details are summarized. The future potential research directions of this valued compound are also discussed to provide reference for future drugs development. Methods: PubMed, Web of Science, CNKI and WanFang databases were used to search current studies and experimental researches about anticancer effect or carcinogenic information of sanguinarine. Results : Our results indicated that sanguinarine exhibited anticancer effect through anti-proliferation, anti-invasion, anti-angiogenesis and apoptosis within cancer lesion. Also, many clinical investigations indicated that sanguinarine and its related products might be associated to pre-carcinoma within oral or skin potentially. Conclusion: Sanguinarine is a natural compounds with good development value for its potent anticancer activity, however, its carcinogenesis effect should also be taken seriously. Studies on structural modification and analogue design should be carried out to improve its safety and efficiency in the future.

Novel natural compounds from endophytic fungi with anticancer activity

2018 ◽  
Vol 156 ◽  
pp. 316-343 ◽  
Author(s):  
Shou-Jie Li ◽  
Xuan Zhang ◽  
Xiang-Hua Wang ◽  
Chang-Qi Zhao
Keyword(s):  
Anticancer Activity ◽  
Endophytic Fungi ◽  
Natural Compounds

Semi-synthesis as a tool for broadening the health applications of bioactive olive secoiridoids: a critical review

2021 ◽  
Author(s):  
Manuela Oliverio ◽  
Monica Nardi ◽  
Maria Luisa Di Gioia ◽  
Paola Costanzo ◽  
Sonia Bonacci ◽  
...  
Keyword(s):  
Critical Review ◽  
Natural Compounds ◽  
Effective Strategy ◽  
Synthetic Analogues ◽  
Health Applications ◽  
Natural And Synthetic

Semi-synthesis is an effective strategy to obtain both natural and synthetic analogues of the olive secoiridoids, starting from easy accessible natural compounds.

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