Integration of digital microfluidics with whispering-gallery mode sensors for label-free detection of biomolecules

Lab on a Chip ◽  
2017 ◽  
Vol 17 (10) ◽  
pp. 1740-1748 ◽  
Author(s):  
Sentayehu F. Wondimu ◽  
Sebastian von der Ecken ◽  
Ralf Ahrens ◽  
Wolfgang Freude ◽  
Andreas E. Guber ◽  
...  
Keyword(s):  
Refractive Index ◽  
Digital Microfluidics ◽  
Whispering Gallery Mode ◽  
Label Free ◽  
Biosensor Arrays ◽  
Whispering Gallery ◽  
Label Free Detection ◽  
Detection Of Biomolecules

WGM biosensor arrays are integrated with a DMF system. The viability of the system is demonstrated by refractive-index and biosensing experiments.

Handheld readout system for field-effect transistor biosensor arrays for label-free detection of biomolecules

2015 ◽  
Vol 212 (6) ◽  
pp. 1313-1319 ◽  
Author(s):  
Thanh Chien Nguyen ◽  
Miriam Schwartz ◽  
Xuan Thang Vu ◽  
Jörg Blinn ◽  
Sven Ingebrandt
Keyword(s):  
Field Effect ◽  
Field Effect Transistor ◽  
Label Free ◽  
Readout System ◽  
Biosensor Arrays ◽  
Label Free Detection ◽  
Effect Transistor ◽  
Detection Of Biomolecules

Optical whispering gallery mode resonators for label-free detection of water contaminants

2020 ◽  
Vol 126 ◽  
pp. 115856 ◽  
Author(s):  
Simone Berneschi ◽  
Francesca Bettazzi ◽  
Ambra Giannetti ◽  
Francesco Baldini ◽  
Gualtiero Nunzi Conti ◽  
...  
Keyword(s):  
Whispering Gallery Mode ◽  
Label Free ◽  
Water Contaminants ◽  
Whispering Gallery ◽  
Label Free Detection

scholarly journals Chiral Plasmonic Biosensors

Biosensors ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 120 ◽  
Author(s):  
Vladimir Bochenkov ◽  
Tatyana Shabatina
Keyword(s):  
Refractive Index ◽  
Surface Plasmon Resonance ◽  
Plasmonic Nanostructures ◽  
Label Free ◽  
Highly Sensitive ◽  
Label Free Detection ◽  
Recent Developments ◽  
Detection Of Biomolecules ◽  
Local Refractive Index ◽  
Unique Capability

Biosensing requires fast, selective, and highly sensitive real-time detection of biomolecules using efficient simple-to-use techniques. Due to a unique capability to focus light at nanoscale, plasmonic nanostructures provide an excellent platform for label-free detection of molecular adsorption by sensing tiny changes in the local refractive index or by enhancing the light-induced processes in adjacent biomolecules. This review discusses the opportunities provided by surface plasmon resonance in probing the chirality of biomolecules as well as their conformations and orientations. Various types of chiral plasmonic nanostructures and the most recent developments in the field of chiral plasmonics related to biosensing are considered.

scholarly journals Review of biosensing with whispering-gallery mode lasers

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Nikita Toropov ◽  
Gema Cabello ◽  
Mariana P. Serrano ◽  
Rithvik R. Gutha ◽  
Matías Rafti ◽  
...  
Keyword(s):  
Biological Samples ◽  
Whispering Gallery Mode ◽  
Photonic Devices ◽  
Whispering Gallery Modes ◽  
Label Free ◽  
Virus Particles ◽  
Whispering Gallery ◽  
Label Free Detection ◽  
Basic Concepts ◽  
Wgm Resonators

AbstractLasers are the pillars of modern optics and sensing. Microlasers based on whispering-gallery modes (WGMs) are miniature in size and have excellent lasing characteristics suitable for biosensing. WGM lasers have been used for label-free detection of single virus particles, detection of molecular electrostatic changes at biointerfaces, and barcode-type live-cell tagging and tracking. The most recent advances in biosensing with WGM microlasers are described in this review. We cover the basic concepts of WGM resonators, the integration of gain media into various active WGM sensors and devices, and the cutting-edge advances in photonic devices for micro- and nanoprobing of biological samples that can be integrated with WGM lasers.

The whispering gallery mode biosensor: label-free detection from virus to single protein

2014 ◽  
Author(s):  
S. Holler ◽  
V. R. Dantham ◽  
D. Keng ◽  
V. Kolchenko ◽  
S. Arnold ◽  
...  
Keyword(s):  
Whispering Gallery Mode ◽  
Label Free ◽  
Whispering Gallery ◽  
Label Free Detection ◽  
Single Protein
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