Dendritic chitosan as a magnetic and biocompatible nanocarrier for the simultaneous delivery of doxorubicin and methotrexate to MCF-7 cell line

2017 ◽  
Vol 41 (8) ◽  
pp. 3177-3189 ◽  
Author(s):  
Mahdi Rahimi ◽  
Kazem D. Safa ◽  
Effat Alizadeh ◽  
Roya Salehi
Keyword(s):  
Drug Delivery ◽  
Cell Line ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Anticancer Drug Delivery ◽  
Line P ◽  
Simultaneous Delivery ◽  
Mcf 7

A novel smart, biocompatible, and pH-responsive magnetic highly branched chitosan was synthesized efficiently for use in dual-anticancer drug delivery systems.

Cyclodextrin nanosponges as potential anticancer drug delivery systems to be introduced into the market, compared with liposomes

2021 ◽  
pp. 102931
Author(s):  
Saeideh Allahyari ◽  
Fahimeh Zahednezhad ◽  
Mohamad Khatami ◽  
Nastaran Hashemzadeh ◽  
Parvin Zakeri-Milani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Drug Delivery ◽  
Cyclodextrin Nanosponges

Micro/nanomachines: what is needed for them to become a real force in cancer therapy?

Nanoscale ◽  
2019 ◽  
Vol 11 (14) ◽  
pp. 6519-6532 ◽  
Author(s):  
Lucie Reinišová ◽  
Soňa Hermanová ◽  
Martin Pumera
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Future Development ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Drug Delivery

A biomedical perspective is used to assess micro/nanomotor-based anticancer drug delivery systems with recommendations for their effective future development.

scholarly journals Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

2017 ◽  
Vol 8 ◽  
pp. 1457-1468 ◽  
Author(s):  
Gamze Varan ◽  
Juan M Benito ◽  
Carmen Ortiz Mellet ◽  
Erem Bilensoy
Keyword(s):  
Drug Delivery ◽  
Cell Line ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Delivery Systems ◽  
Loading Capacity ◽  
Promising Alternative ◽  
Cytotoxicity Studies ◽  
Amphiphilic Cyclodextrin

Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its bioavailability problems arising from very poor aqueous solubility and tendency to recrystallize upon dilution, paclitaxel is commercially formulated with co-solvents such as Cremophor EL® that are known to cause serious side effects during chemotherapy. Amphiphilic cyclodextrins are favored oligosaccharides as drug delivery systems for anticancer drugs, having the ability to spontaneously form nanoparticles without surfactant or co-solvents. In the past few years, polycationic, amphiphilic cyclodextrins were introduced as effective agents for gene delivery in the form of nanoplexes. In this study, the potential of polycationic, amphiphilic cyclodextrin nanoparticles were evaluated in comparison to non-ionic amphiphilic cyclodextrins and core–shell type cyclodextrin nanoparticles for paclitaxel delivery to breast tumors. Pre-formulation studies were used as a basis for selecting the suitable organic solvent and surfactant concentration for the novel polycationic cyclodextrin nanoparticles. The nanoparticles were then extensively characterized with particle size distribution, polydispersity index, zeta potential, drug loading capacity, in vitro release profiles and cytotoxicity studies. Results: Paclitaxel-loaded cyclodextrin nanoparticles were obtained in the diameter range of 80−125 nm (depending on the nature of the cyclodextrin derivative) where the smallest diameter nanoparticles were obtained with polycationic (PC) βCDC6. A strong positive charge also helped to increase the loading capacity of the nanoparticles with paclitaxel up to 60%. Interestingly, cyclodextrin nanoparticles were able to stabilize paclitaxel in aqueous solution for 30 days. All blank cyclodextrin nanoparticles were demonstrated to be non-cytotoxic against L929 mouse fibroblast cell line. In addition, paclitaxel-loaded nanoparticles have a significant anticancer effect against MCF-7 human breast cancer cell line as compared with a paclitaxel solution in DMSO. Conclusion: According to the results of this study, both amphiphilic cyclodextrin derivatives provide suitable nanometer-sized drug delivery systems for safe and efficient intravenous paclitaxel delivery for chemotherapy. In the light of these studies, it can be said that amphiphilic cyclodextrin nanoparticles of different surface charge can be considered as a promising alternative for self-assembled nanometer-sized drug carrier systems for safe and efficient chemotherapy.

Anticancer Drug Delivery Systems Based on Curcumin Nanostructures: A Review

2020 ◽  
Vol 54 (4) ◽  
pp. 353-360
Author(s):  
Zahra Mirzaie ◽  
Mohammad Barati ◽  
Mohammad Asadi Tokmedash
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Drug Delivery

Development of curcumin–cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

2016 ◽  
Vol 26 (3) ◽  
pp. 941-945 ◽  
Author(s):  
Gautier M.A. Ndong Ntoutoume ◽  
Robert Granet ◽  
Jean Pierre Mbakidi ◽  
Frédérique Brégier ◽  
David Y. Léger ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Cellulose Nanocrystals ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Drug Delivery

Anticancer drug delivery systems based on noncovalent interactions between carbon nanotubes and linear–dendritic copolymers

Soft Matter ◽  
2011 ◽  
Vol 7 (8) ◽  
pp. 4062 ◽  
Author(s):  
Mohsen Adeli ◽  
Farahman Hakimpoor ◽  
Masoumeh Ashiri ◽  
Roya Kabiri ◽  
Masoumeh Bavadi
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Noncovalent Interactions ◽  
Delivery Systems ◽  
Anticancer Drug Delivery

Nanoparticles and mesenchymal stem cells: a win-win alliance for anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 36910-36922 ◽  
Author(s):  
Min Li ◽  
Fangrong Zhang ◽  
Kerong Chen ◽  
Cheng Wang ◽  
Yujie Su ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Drug Delivery

Schematic illustration of the combination of NPs and MSCs drug delivery systems for cancer therapy.

Sign in / Sign up

Export Citation Format

Share Document