Towards mismatched DNA photoprobes and photoreagents: “elbow-shaped” Ru(ii) complexes

2017 ◽  
Vol 4 (1) ◽  
pp. 91-103 ◽  
Author(s):  
Q. Deraedt ◽  
L. Marcélis ◽  
F. Loiseau ◽  
B. Elias
Keyword(s):  
Mismatched Dna ◽  
High Interest ◽  
Dna Mismatches ◽  
Planar Ligands

Due to their potentially harmful consequences, the detection of mismatched DNA is a subject of high interest. In order to probe these DNA mismatches, we report new Ru(ii) complexes, bearing “elbow-shaped” extended planar ligands based on an acridine or a phenazine core.

Lack of Credit in Albania; Who is to “Blame” Analyzing the Demand

2015 ◽  
Vol 3 (1) ◽  
pp. 122
Author(s):  
Eugen Musta ◽  
Elvin Meka
Keyword(s):  
Interest Rates ◽  
Small Sample ◽  
Economic Situation ◽  
Demand Side ◽  
Working Capital ◽  
Global Crisis ◽  
High Interest ◽  
Future Perceptions ◽  
Economic Slowdown ◽  
To Come

The last global crisis had it influence on Albanian economy as well. As the economy is still struggling to recover from the slowdown, a special attention is dedicated to lending which will in turn help investments pick up. Banks in Albania are currently flooding in excess deposits, but meanwhile the lending has hit its lowest score. What is refraining banks from lending? Is it really them to blame or maybe the demand is also part of the problem? Are businesses suffering from lack of funds to finance their activity or are they hesitating to invest and are waiting for better times to come along? The purpose of this study is to look into these questions and find the reasons behind them. This paper is focused on the demand side, analyzing some of the most important indicators influencing the demand for credit like enterprises growth, profits, planned investments, working capital needs, liquidity, etc. In order to get better understanding on the behavior of these variables the enterprises are divided in four groups by size criteria. The analysis is covering data for five-year timeframe, which is corresponding with the start of the economic slowdown. To help getting a prospect of the present and the future perceptions of the economic situation, a survey was conducted on a small sample of enterprises. This study comes to the conclusion that the demand for credit is growing, but what’s keeping businesses from applying for it, is mainly because of high interest rates and cost of credit, the study ends with some recommendations toward the solution.

Un estudio de caso en el análisis de la espiritualidad en el trabajo

Oikos ◽  
2016 ◽  
Vol 19 (39) ◽  
pp. 29
Author(s):  
Zahira Moreno Freites ◽  
María García Jiménez ◽  
Judith Hernández
Keyword(s):  
Qualitative Analysis ◽  
Work Environment ◽  
Theoretical Framework ◽  
Personal Life ◽  
Theoretical Construct ◽  
Spiritual Beliefs ◽  
High Interest ◽  
Beliefs And Values ◽  
The Subject ◽  
Estudio De Caso

RESUMENEsta investigación examina la espiritualidad y su consideración en el ambiente laboral, específicamente en los trabajadores de la Dirección de Educación Estadal del Municipio Palavecino, Estado Lara, Venezuela. El estudio de tipo descriptivo y cualitativo permitió analizar materiales teóricos relacionados con la espiritualidad en el trabajo, tomando el concepto de espiritualidad de Mitroff y Denton (1999) como marco teórico para esta investigación, además de los aportes de Pérez (2007) y Robles (2011) que exploran el tema y permitieron la elaboración de un constructo teórico para esta investigación. Los resultados evidencian que existe un alto interés por el tema de la espiritualidad tanto en la vida personal como en el trabajo y puede tratarse abiertamente en el ámbito laboral, a pesar de las limitaciones sobre el tema, su principal beneficio es que favorece el equilibrio en todos los aspectos de la vida.Palabras clave: espiritualidad, ambiente laboral, creencias y valores espirituales.An study of case on the analysis of spirituality at the workABSTRACT This research examines spirituality and its consideration in the workplace, specifically on workers of the Directorate of Education of the Municipality Palavecino State Authority, State Lara, Venezuela. The study of descriptive and qualitative analysis allowed theoretical materials related to spirituality at work, taking the concept of spirituality Mitroff and Denton (1999 ) as the theoretical framework for this research, along with the contributions of Perez (2007) and Robles ( 2011) that explore the issue and allowed the development of a theoretical construct for this research. Los results show that there is a high interest in the topic of spirituality both in personal life and at work and can openly addressed in the workplace, despite the limitations on the subject, its main benefit s that it favors the balance in all aspects of life .Keywords: spirituality, work environment, spiritual beliefs and values. Um estudo de caso na análise da espiritualidade no trabalho RESUMO Esta pesquisa analisa a espiritualidade e sua consideração no local de trabalho, especificamente nos trabalhadores do Departamento de Educação Estadual do Município Palavecino, Estado de Lara, Venezuela. O estudo de análise descritiva e qualitativa permitiu investigar materiais teóricos relacionados à espiritualidade no trabalho, tomando o conceito de espiritualidade de Mitroff e Denton (1999) como marco teórico para esta pesquisa, juntamente com as contribuições de Pérez (2007) e Robles ( 2011) que exploram o tema e permitiram o desenvolvimento de uma construção teórica para esta pesquisa. Os resultados mostram que existe um alto interesse pela temática da espiritualidade tanto na vida pessoal como no trabalho e pode-se tratar abertamente no espaço de trabalho, apesar das limitações sobre o assunto, seu principal benefício é que favorece o equilíbrio em todos os aspectos da vida.Palavras-chave: espiritualidade, ambiente de trabalho, crenças e valores espirituais.

Sistem Pendukung Keputusan Pemilihan Taksi Berbasis Web dengan Algoritma Pencarian Linear

2016 ◽  
Vol 7 (2) ◽  
pp. 148-154
Author(s):  
Bimo Satriantoro ◽  
Ni Made Satvika Iswari
Keyword(s):  
Public Transportation ◽  
Time Variable ◽  
Variable Speed ◽  
Linear Algorithm ◽  
High Interest ◽  
Distance Variable ◽  
Google Apps

Indonesian people have a high interest for public transportation. There are few kind of public transportation, and taxi is one of them. Taxi use taximeter to calculate passanger fares. Taximeters between taxi companies are different in term of results although using the same equation and principle. The total fare from the taximeter is based on equation that includes distance variable, speed of the vehicle, and time variable. People have a problem to choose taxi because of the differnces of taximeter fares and taxi pool. Based on the problem, the solution is an application to help customer to decide choosing taxi. The application will help customer by giving informations about taximeter and carpool form two different company. The informations are based on the distance of the start point and the finish point of the customer and based on the distances of the customer and the carpool of the taxy company that will processed trough the application to calculating the total fares for the customer between two taxi companies. By using algorithm for linear searching, customer will get the informations to help them to decide which taxi the customer will use. Keywords: Linear Algorithm, Taximeter, Google Apps, Choice, Taxi

Δα,β-Butenolides [Furan-2(5H)-ones]: Ring Construction Approaches and Biological Aspects - A Mini-Review

2020 ◽  
Vol 17 (8) ◽  
pp. 922-945
Author(s):  
Andrés-Felipe Villamizar-Mogotocoro ◽  
Andrés-Felipe León-Rojas ◽  
Juan-Manuel Urbina-González
Keyword(s):  
Biological Activities ◽  
Ring Formation ◽  
High Interest ◽  
The Past ◽  
Biological Aspects ◽  
Synthetic Methodologies ◽  
New Procedures

The five-membered oxacyclic system of furan-2(5H)-ones, commonly named as γ- butenolides or appropriately as Δα,β-butenolides, is of high interest since many studies have proven its bioactivity. During the past few years, Δα,β-butenolides have been important synthetic targets, with several reports of new procedures for their construction. A short compendium of the main different synthetic methodologies focused on the Δα,β-butenolide ring formation, along with selected examples of compounds with relevant biological activities of these promising pharmaceutical entities is presented.

High Interest Paper Kalman Filtering Applied to Power System Measurements for Relaying

1987 ◽  
Vol PER-7 (9) ◽  
pp. 21-27
Author(s):  
M. S. Sachdev ◽  
H. C. Wood ◽  
N. S. Johnson
Keyword(s):  
Power System ◽  
Kalman Filtering ◽  
High Interest

scholarly journals Risk assessment of recent high-interest conjunctions

2021 ◽  
Author(s):  
Salvatore Alfano ◽  
Daniel Oltrogge ◽  
Holger Krag ◽  
Klaus Merz ◽  
Robert Hall
Keyword(s):  
Risk Assessment ◽  
High Interest

Key factors in the synthesis of polycyclic iridaaromatics via the methoxyalkenylcarbene pathway

2021 ◽  
Author(s):  
Maria Talavera ◽  
Krystal M. Cid-Seara ◽  
Ángeles Peña-Gallego ◽  
Sandra Bolaño
Keyword(s):  
Key Factors ◽  
High Interest ◽  
Made In

Polycyclic iridaaromatic compounds are of high interest not only because of the contributions made in “aromatic chemistry” but also because of the possibility of improving the results of the applications...

scholarly journals Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shih-Chi Luo ◽  
Hsin-Yi Yeh ◽  
Wei-Hsuan Lan ◽  
Yi-Min Wu ◽  
Cheng-Han Yang ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Structural Analysis ◽  
Md Simulation ◽  
Structural Basis ◽  
High Fidelity ◽  
Dna Dynamics ◽  
Genomic Integrity ◽  
Mismatched Dna ◽  
Dna Backbone ◽  
Loop 2

AbstractBoth high-fidelity and mismatch-tolerant recombination, catalyzed by RAD51 and DMC1 recombinases, respectively, are indispensable for genomic integrity. Here, we use cryo-EM, MD simulation and functional analysis to elucidate the structural basis for the mismatch tolerance of DMC1. Structural analysis of DMC1 presynaptic and postsynaptic complexes suggested that the lineage-specific Loop 1 Gln244 (Met243 in RAD51) may help stabilize DNA backbone, whereas Loop 2 Pro274 and Gly275 (Val273/Asp274 in RAD51) may provide an open “triplet gate” for mismatch tolerance. In support, DMC1-Q244M displayed marked increase in DNA dynamics, leading to unobservable DNA map. MD simulation showed highly dispersive mismatched DNA ensemble in RAD51 but well-converged DNA in DMC1 and RAD51-V273P/D274G. Replacing Loop 1 or Loop 2 residues in DMC1 with RAD51 counterparts enhanced DMC1 fidelity, while reciprocal mutations in RAD51 attenuated its fidelity. Our results show that three Loop 1/Loop 2 residues jointly enact contrasting fidelities of DNA recombinases.

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