Dose-dependent enhancement of octacalcium phosphate biodegradation with a gelatin matrix during bone regeneration in a rabbit tibial defect model

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64165-64174 ◽  
Author(s):  
Keisuke Saito ◽  
Takahisa Anada ◽  
Yukari Shiwaku ◽  
Shinpei Chiba ◽  
Naohisa Miyatake ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Octacalcium Phosphate ◽  
Defect Model ◽  
Gelatin Matrix ◽  
Tibial Defect ◽  
Rabbit Tibia ◽  
Biodegradable Properties ◽  
Dose Dependent ◽  
Tibia Defect

The present study was designed to investigate how the dose of granular octacalcium phosphate in a gelatin matrix affects its bone regenerative and biodegradable properties in a rabbit tibia defect.

scholarly journals STIMULATORY CAPACITY OF AN OCTACALCIUM PHOSPHATE/GELATIN COMPOSITE ON BONE REGENERATION IN A RABBIT TIBIA DEFECT MODEL

2012 ◽  
Vol 26 (0) ◽  
pp. 53-58 ◽  
Author(s):  
Kentaro Suzuki ◽  
Yoshitomo Honda ◽  
Takahisa Anada ◽  
Takuto Handa ◽  
Naohisa Miyatake ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Octacalcium Phosphate ◽  
Defect Model ◽  
Rabbit Tibia ◽  
Stimulatory Capacity ◽  
Tibia Defect

scholarly journals The Effect of Alendronate Loaded Biphasic Calcium Phosphate Scaffolds on Bone Regeneration in a Rat Tibial Defect Model

2015 ◽  
Vol 16 (11) ◽  
pp. 26738-26753 ◽  
Author(s):  
Kwang-Won Park ◽  
Young-Pil Yun ◽  
Sung Kim ◽  
Hae-Ryong Song
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Biphasic Calcium Phosphate ◽  
Defect Model ◽  
Tibial Defect

Application of a new bioresorbable film to guided bone regeneration in tibia defect model of the rabbits

2007 ◽  
Vol 82A (1) ◽  
pp. 256-262 ◽  
Author(s):  
Hong He ◽  
Jianqi Huang ◽  
Guanfu Chen ◽  
Yan Dong
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Defect Model ◽  
Tibia Defect

scholarly journals Octacalcium Phosphate Bone Substitute (Bontree®): From Basic Research to Clinical Case Study

2021 ◽  
Vol 11 (17) ◽  
pp. 7921
Author(s):  
Joo-Seong Kim ◽  
Tae-Sik Jang ◽  
Suk-Young Kim ◽  
Won-Pyo Lee
Keyword(s):  
Bone Regeneration ◽  
Bone Substitute ◽  
Alveolar Bone ◽  
Basic Research ◽  
Octacalcium Phosphate ◽  
Sinus Augmentation ◽  
Mg63 Cells ◽  
Rabbit Tibia ◽  
Clinical Cases

Bone grafts used in alveolar bone regeneration can be categorized into autografts, allografts, xenografts, and synthetic bones, depending on their origin. The purpose of this study was to evaluate the effect of a commercialized octacalcium phosphate (OCP)-based synthetic bone substitute material (Bontree®) in vitro, in vivo, and in clinical cases. Material characterization of Bontree® granules (0.5 mm and 1.0 mm) using scanning electron microscopy and X-ray diffraction showed that both 0.5 mm and 1.0 mm Bontree® granules were uniformly composed mainly of OCP. The receptor activator of NF-κB ligand (RANKL) and alkaline phosphatase (ALP) activities of MG63 cells were assessed and used to compare Bontree® with a commercial biphasic calcium phosphate ceramic (MBCP+TM). Compared with MBCP+TM, Bontree® suppressed RANKL and increased ALP activity. A rabbit tibia model used to examine the effects of granule size of Bontree® grafts showed that 1.0 mm Bontree® granules had a higher new bone formation ability than 0.5 mm Bontree® granules. Three clinical cases using Bontree® for ridge or sinus augmentation are described. All eight implants in the three patients showed a 100% success rate after 1 year of functional loading. This basic research and clinical application demonstrated the safety and efficacy of Bontree® for bone regeneration.

Bone Regeneration With a Collagen Model Polypeptides/α-Tricalcium Phosphate Sponge in a Canine Tibia Defect Model

2015 ◽  
pp. 1 ◽  
Author(s):  
Tomohiko Ito ◽  
Yoshiya Hashimoto ◽  
Shunsuke Baba ◽  
Tomio Iseki ◽  
Shosuke Morita
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Defect Model ◽  
Tibia Defect

Validation of a finite element model of a unilateral external fixator in a rabbit tibia defect model

2013 ◽  
Vol 35 (7) ◽  
pp. 1037-1043 ◽  
Author(s):  
Kavin Karunratanakul ◽  
Greet Kerckhofs ◽  
Johan Lammens ◽  
Johan Vanlauwe ◽  
Jan Schrooten ◽  
...  
Keyword(s):  
Finite Element ◽  
Finite Element Model ◽  
External Fixator ◽  
Element Model ◽  
Defect Model ◽  
Rabbit Tibia ◽  
Tibia Defect

scholarly journals Nurse’s A-Phase–Silicocarnotite Ceramic–Bone Tissue Interaction in a Rabbit Tibia Defect Model

2019 ◽  
Vol 8 (10) ◽  
pp. 1714 ◽  
Author(s):  
Belén Ñíguez Sevilla ◽  
Ruben Rabadan-Ros ◽  
Miguel Alcaraz-Baños ◽  
Francisco Martínez Díaz ◽  
José E. Mate Sánchez de Val ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Porous Ceramic ◽  
Bone Substitutes ◽  
Physicochemical Characteristics ◽  
Defect Model ◽  
X Ray ◽  
Ceramic Scaffold ◽  
Rabbit Tibia ◽  
Sintering Method ◽  
Tibia Defect

Calcium phosphate materials are widely used as bone substitutes due to their bioactive and biodegradable properties. Also, the presence of silicon in their composition seems to improve the bioactivity of the implant and promote bone tissue repair. The aim of this study was to develop a novel ceramic scaffold by partial solid-state sintering method with a composition lying in the field of the Nurse’s A-phase–silicocarnotite, in the tricalcium phosphate–dicalcium silicate (TCP–C2S) binary system. Also, we evaluated its osteogenic and osteoconductive properties after being implanted into tibia defects in New Zealand rabbits. X-ray, microcomputer tomography, and histomorphometry studies demonstrated that this porous ceramic is highly biocompatible and it has excellent osteointegration. The material was being progressively reabsorbed throughout the study and there was no unspecified local or systemic inflammatory response observed. These results suggest that ceramic imitates the physicochemical characteristics of bone substitutes used in bone reconstruction.

Evaluation of Bone Regeneration with an Injectable, In Situ Polymerizable Pluronic® F127 Hydrogel Derivative Combined with Autologous Mesenchymal Stem Cells in a Goat Tibia Defect Model

2010 ◽  
Vol 16 (2) ◽  
pp. 617-627 ◽  
Author(s):  
Evi Lippens ◽  
Geert Vertenten ◽  
Jordi Gironès ◽  
Heidi Declercq ◽  
Jimmy Saunders ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Regeneration ◽  
Defect Model ◽  
Autologous Mesenchymal Stem Cells ◽  
Tibia Defect

Bone regeneration by bone morphogenetic protein-2 from porous beads with leaf-stacked structure for critical-sized femur defect model in dogs

2020 ◽  
Vol 34 (10) ◽  
pp. 1437-1448 ◽  
Author(s):  
Sung Jin Hong ◽  
Se Heang Oh ◽  
Sung Lim Lee ◽  
Na-Hyun Kim ◽  
Yong Ho Choe ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 2 ◽  
Defect Model ◽  
Morphogenetic Protein ◽  
Porous Beads
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