Magnetic iron oxide nanoparticles encapsulating horseradish peroxidase (HRP): synthesis, characterization and carrier for the generation of free radicals for potential applications in cancer therapy

Orientation of cellulose nanowhiskers (CNWs) within various matrices is an effective approach that affords the exploitation of the high stiffness of CNWs as a reinforcement phase in nanocomposites. One potential engineering method to achieve orientation is to incorporate magnetic properties into the CNWs by tethering magnetic nanoparticles onto the surface of these nanoparticles, followed by their alignment in an externally-applied magnetic field. In this work we report the successful in-situ tethering of iron oxide nanoparticles (IONPs) onto CNWs by the thermal decomposition of Fe(CO)5 in a H2O/DMF suspension. Following this procedure, IONPs consisting of mixtures of Fe3O4 and Fe2O3 with an average diameter of 20 nm were attached to the CNWs. The type of iron oxide species that was generated was determined by selected area electron diffraction (SAED) and energy dispersive spectroscopy (EDS) and the particle size was evaluated by transmission electron microscopy (TEM). Raman spectroscopy was used to characterize the presence and the nature of the molecular interaction between the IONPs and the CNWs.

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Decoration of Cellulose Nanowhiskers with Iron Oxide Nanoparticles

10.26434/chemrxiv.6987461 ◽

2018 ◽

Author(s):

Lyufei Chen ◽

Shruti Sharma ◽

Richard Darienzo ◽

Rina Tannenbaum

Keyword(s):

Magnetic Field ◽

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Average Diameter ◽

Oxide Nanoparticles ◽

Cellulose Nanowhiskers ◽

Selected Area Electron Diffraction ◽

Transmission Electron ◽

20 Nm

Orientation of cellulose nanowhiskers (CNWs) within various matrices is an effective approach that affords the exploitation of the high stiffness of CNWs as a reinforcement phase in nanocomposites. One potential engineering method to achieve orientation is to incorporate magnetic properties into the CNWs by tethering magnetic nanoparticles onto the surface of these nanoparticles, followed by their alignment in an externally-applied magnetic field. In this work we report the successful in-situ tethering of iron oxide nanoparticles (IONPs) onto CNWs by the thermal decomposition of Fe(CO)5 in a H2O/DMF suspension. Following this procedure, IONPs consisting of mixtures of Fe3O4 and Fe2O3 with an average diameter of 20 nm were attached to the CNWs. The type of iron oxide species that was generated was determined by selected area electron diffraction (SAED) and energy dispersive spectroscopy (EDS) and the particle size was evaluated by transmission electron microscopy (TEM). Raman spectroscopy was used to characterize the presence and the nature of the molecular interaction between the IONPs and the CNWs.

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Magnetic ELISA of aflatoxin B1 – pre-concentration without elution

Analytical Methods ◽

10.1039/c5ay02386f ◽

2015 ◽

Vol 7 (24) ◽

pp. 10177-10184 ◽

Cited By ~ 6

Author(s):

A. V. Petrakova ◽

A. E. Urusov ◽

A. V. Zherdev ◽

B. B. Dzantiev

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Aflatoxin B1 ◽

Average Diameter ◽

Oxide Nanoparticles ◽

Magnetic Iron Oxide Nanoparticles ◽

Magnetic Iron Oxide ◽

Highly Dispersed

This study proposes an ELISA variant based on the application of highly dispersed (average diameter – 10 nm) magnetic iron oxide nanoparticles as carriers for the adsorbable antibodies.

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