Investigating allosteric effects on the functional dynamics of β2-adrenergic ternary complexes with enhanced-sampling simulations
Keyword(s):
We propose an experimentally testable extended ternary complex model, where direction of the cooperative effect between ligand and intracellular binding partner (positive or negative) and its magnitude are predicted to be a characteristic of the ligand signaling bias.
Keyword(s):
1987 ◽
Vol 253
(1)
◽
pp. E114-E121
2007 ◽
Vol 12
(5)
◽
pp. 668-676
◽
Keyword(s):
1993 ◽
Vol 268
(16)
◽
pp. 11881-11887
2011 ◽
Vol 9
(10)
◽
pp. 2123-2126
◽
1980 ◽
Vol 255
(15)
◽
pp. 7108-7117
◽
1993 ◽
Vol 268
(7)
◽
pp. 4625-4636
◽
Keyword(s):