scholarly journals In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe

2017 ◽  
Vol 8 (5) ◽  
pp. 3479-3483 ◽  
Author(s):  
Xinyuan He ◽  
Lihong Li ◽  
Yu Fang ◽  
Wen Shi ◽  
Xiaohua Li ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Leucine Aminopeptidase ◽  
Aminopeptidase Activity ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
First Time

The upregulation of leucine aminopeptidase in hepatopathy models is imaged in vivo for the first time with a near-infrared fluorescent probe.

Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N

2017 ◽  
Vol 53 (68) ◽  
pp. 9438-9441 ◽  
Author(s):  
Xinyuan He ◽  
Yiming Hu ◽  
Wen Shi ◽  
Xiaohua Li ◽  
Huimin Ma
Keyword(s):  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Aminopeptidase N ◽  
Design Synthesis ◽  
First Time

We have, for the first time, developed a near-infrared fluorescent probe for aminopeptidase N by combining a hemicyanine and an alanyl residue.

A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation

2019 ◽  
Vol 55 (95) ◽  
pp. 14307-14310 ◽  
Author(s):  
Wen-Li Jiang ◽  
Yongfei Li ◽  
Wen-Xin Wang ◽  
Yi-Ting Zhao ◽  
Junjie Fei ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Ratiometric Fluorescent Probe

A novel hepatocyte-targeting near-infrared ratiometric fluorescent probe named Gal-NIR is developed for detecting ONOO−. The probe can target the hepatocyte and assess drug-induced liver injury and its remediation in living cells and mice.

A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection

2019 ◽  
Vol 55 (17) ◽  
pp. 2541-2544 ◽  
Author(s):  
Xiaodong Zeng ◽  
Ziyang Chen ◽  
Lin Tang ◽  
Han Yang ◽  
Nan Liu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Fluorescence Probe ◽  
Fluorescent Light ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Nir Fluorescence

A novel light-up NIR fluorescence probe was developed and used for tumor and drug-induced liver injury imaging in vivo.

Engineering dithiobenzoic acid lactone-decorated Si-rhodamine as a highly selective near-infrared HOCl fluorescent probe for imaging drug-induced acute nephrotoxicity

2019 ◽  
Vol 55 (73) ◽  
pp. 10916-10919 ◽  
Author(s):  
Jinping Wang ◽  
Dan Cheng ◽  
Longmin Zhu ◽  
Peng Wang ◽  
Hong-Wen Liu ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Drug Induced ◽  
Acid Lactone ◽  
First Time

A NIR fluorescent probe based on Si-rhodamine dithiobenzoic acid lactone was used to selectively visualize HOCl during GEN-induced nephrotoxicity for the first time.

Drug-induced liver injury classification model based on in vitro human transcriptomics and in vivo rat clinical chemistry data

2014 ◽  
Vol 2 (4) ◽  
pp. 63-70 ◽  
Author(s):  
Danyel Jennen ◽  
Jan Polman ◽  
Mark Bessem ◽  
Maarten Coonen ◽  
Joost van Delft ◽  
...  
Keyword(s):  
Liver Injury ◽  
Clinical Chemistry ◽  
Classification Model ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Chemistry Data ◽  
Model Based ◽  
Injury Classification

A hypoxia-activated near infrared fluorescent probe for cyclooxygenase-2 and in vivo imaging for tumor and inflammation

2018 ◽  
Vol 265 ◽  
pp. 582-590 ◽  
Author(s):  
Yuezheng Ti ◽  
Ling Yu ◽  
Yao Tang ◽  
Tongxia Jin ◽  
Ming Yang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Cyclooxygenase 2
Sign in / Sign up

Export Citation Format

Share Document