A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation

2019 ◽  
Vol 55 (95) ◽  
pp. 14307-14310 ◽  
Author(s):  
Wen-Li Jiang ◽  
Yongfei Li ◽  
Wen-Xin Wang ◽  
Yi-Ting Zhao ◽  
Junjie Fei ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Ratiometric Fluorescent Probe

A novel hepatocyte-targeting near-infrared ratiometric fluorescent probe named Gal-NIR is developed for detecting ONOO−. The probe can target the hepatocyte and assess drug-induced liver injury and its remediation in living cells and mice.

BODIPY-based near-infrared fluorescent probe for diagnosis drug-induced liver injury via imaging of HClO in cells and in vivo

2021 ◽  
pp. 110073
Author(s):  
Guanwen Fan ◽  
Nannan Wang ◽  
Jian Zhang ◽  
Xin Ji ◽  
Shuchun Qin ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
In Cells

scholarly journals In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe

2017 ◽  
Vol 8 (5) ◽  
pp. 3479-3483 ◽  
Author(s):  
Xinyuan He ◽  
Lihong Li ◽  
Yu Fang ◽  
Wen Shi ◽  
Xiaohua Li ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Leucine Aminopeptidase ◽  
Aminopeptidase Activity ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
First Time

The upregulation of leucine aminopeptidase in hepatopathy models is imaged in vivo for the first time with a near-infrared fluorescent probe.

Rational design of a fluorescent probe for the detection of LAP and its application in drug-induced liver injury

2021 ◽  
Vol 251 ◽  
pp. 119362
Author(s):  
Tao Liu ◽  
Manman Tian ◽  
Jiayue Wang ◽  
Xiangge Tian ◽  
Jihong Liu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fluorescent Probe ◽  
Rational Design ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Development of a near-infrared ratiometric fluorescent probe for glutathione using an intramolecular charge transfer signaling mechanism and its bioimaging application in living cells

2019 ◽  
Vol 7 (5) ◽  
pp. 809-814 ◽  
Author(s):  
Yong Zhou ◽  
Li Zhang ◽  
Xuan Zhang ◽  
Zhi-Jia Zhu
Keyword(s):  
Aqueous Solution ◽  
Charge Transfer ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Intramolecular Charge Transfer ◽  
Living Cells ◽  
Selective Detection ◽  
Signaling Mechanism ◽  
Acetyl Group ◽  
Ratiometric Fluorescent Probe

A novel NIR ratiometric fluorescent probe HBT-GSH was developed for the selective detection of GSH over Cys and Hcy in aqueous solution. The signaling mechanism of the GSH-induced removal of an acetyl group and the switching on of ICT fluorescence was proposed.

A near-infrared ratiometric fluorescent probe for rapid and highly sensitive imaging of endogenous hydrogen sulfide in living cells

2013 ◽  
Vol 4 (6) ◽  
pp. 2551 ◽  
Author(s):  
Xu Wang ◽  
Juan Sun ◽  
Weihong Zhang ◽  
Xiaoxu Ma ◽  
Jianzheng Lv ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
Highly Sensitive ◽  
Ratiometric Fluorescent Probe

A mitochondria-targeted near infrared ratiometric fluorescent probe for the detection of sulfite in aqueous and in living cells

Talanta ◽  
2018 ◽  
Vol 189 ◽  
pp. 429-436 ◽  
Author(s):  
Yuhua Yao ◽  
Qian Sun ◽  
Zhaoyang Chen ◽  
Rui Huang ◽  
Weibing Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
Ratiometric Fluorescent Probe
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