Intratumoral H2O2-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy

2017 ◽  
Vol 53 (40) ◽  
pp. 5557-5560 ◽  
Author(s):  
Zhaokui Jin ◽  
Yanyuan Wen ◽  
Liwei Xiong ◽  
Tian Yang ◽  
Penghe Zhao ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Metal Carbonyl ◽  
Silica Nanoparticle ◽  
Triggered Release ◽  
Mesoporous Silica Nanoparticle ◽  
Hollow Mesoporous Silica ◽  
Manganese Carbonyl ◽  
Co Gas

H2O2-triggered release of CO: an intratumoral H2O2-responsive nanomedicine is constructed by effectively encapsulating the hydrophilic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize selective killing of tumor cells, exhibiting high in vitro and in vivo efficacies of CO gas therapy.

Uniform hollow mesoporous silica nanocages for drug delivery in vitro and in vivo for liver cancer therapy

2011 ◽  
Vol 21 (14) ◽  
pp. 5299 ◽  
Author(s):  
Tingting Wang ◽  
Fang Chai ◽  
Qin Fu ◽  
Lingyu Zhang ◽  
Haiyan Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Liver Cancer ◽  
Mesoporous Silica ◽  
Hollow Mesoporous Silica

scholarly journals A Novel H2O2 Generator for Tumor Chemotherapy-Enhanced CO Gas Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Yang Li ◽  
Zeming Liu ◽  
Weng Zeng ◽  
Ziqi Wang ◽  
Chunping Liu ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release ◽  
Tumor Microenvironment ◽  
Tumor Site ◽  
Co Poisoning ◽  
Chemotherapy Agent ◽  
Manganese Carbonyl ◽  
Co Gas

Carbon monoxide (CO) gas therapy is a promising cancer treatment. However, gas delivery to the tumor site remains problematic. Proper tunable control of CO release in tumors is crucial to increasing the efficiency of CO treatment and reducing the risk of CO poisoning. To overcome such challenges, we designed ZCM, a novel stable nanotechnology delivery system comprising manganese carbonyl (MnCO) combined with anticancer drug camptothecin (CPT) loaded onto a zeolitic imidazole framework-8 (ZIF-8). After intravenous injection, ZCM gradually accumulates in cancerous tissues, decomposing in the acidic tumor microenvironment, releasing CPT and MnCO. CPT acts as a chemotherapy agent destroying tumors and producing copious H2O2. MnCO can react with the H2O2 to generate CO, powerfully damaging the tumor. Both in vitro and in vivo experiments indicate that the ZCM system is both safe and has excellent tumor inhibition properties. ZCM is a novel system for CO controlled release, with significant potential to improve future cancer therapy.

Graphene quantum dot-decorated mesoporous silica nanoparticles for high aspirin loading capacity and its pH-triggered release

2016 ◽  
Vol 8 (12) ◽  
pp. 2561-2567 ◽  
Author(s):  
Shaping Huang ◽  
Liping Song ◽  
Zhidong Xiao ◽  
Yue Hu ◽  
Meiwen Peng ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Quantum Dot ◽  
Mesoporous Silica ◽  
Mesoporous Silica Nanoparticles ◽  
Graphene Quantum Dots ◽  
Silica Nanoparticle ◽  
Loading Capacity ◽  
Triggered Release ◽  
Mesoporous Silica Nanoparticle ◽  
Graphene Quantum Dot

In this paper, fluorescent graphene quantum dots (GQDs) grafted onto the surface of mesoporous silica nanoparticle (MSN) vehicles were prepared and characterized.

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