scholarly journals Stability and growth mechanism of self-assembling putative antifreeze cyclic peptides

2017 ◽  
Vol 19 (29) ◽  
pp. 19032-19042 ◽  
Author(s):  
Z. Faidon Brotzakis ◽  
Mascha Gehre ◽  
Ilja K. Voets ◽  
Peter G. Bolhuis
Keyword(s):  
Growth Mechanism ◽  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Growth Mechanisms ◽  
Self Assembling ◽  
Peptide Nanotube ◽  
Cyclic Peptide Nanotube

From right to left: three distinct growth mechanisms of a pentamer to a hexamer putative antifreeze cyclic peptide nanotube.

Self-Assembly Effects of Cyclic Peptide Dimers: Molecular Modeling Study

2007 ◽  
Vol 353-358 ◽  
pp. 2257-2260
Author(s):  
Jing Chuan Zhu ◽  
Jie Cheng ◽  
Bo Liu
Keyword(s):  
Self Assembly ◽  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
The Self ◽  
Transport Channel ◽  
Structure And Property ◽  
Self Assembling ◽  
Intermolecular Hydrogen Bonding Interaction ◽  
Bonding Interaction ◽  
Peptide Nanotube

The cyclic peptides can self-assemble into β-sheet like antiparallel tubular ensembles through intermolecular hydrogen-bonding interaction. Under the self-assembling effects of the dimer subunits, various aggregate properties may alter with the change of the structure. The relationship between the property and structure of ensembles is extremely important for designing new nanostructures. Molecular mechanics (MM) and molecular dynamics (MD) were employed to investigate the structure and property of single dimer and dimer-ensemble from cyclo-[D-Phe-(1R, 3S)-γ-Acc]3. Results reveal that the single dimer cannot adsorb CHCl3 molecule into its cavity, while the two-dimer ensemble can do. It suggests that the self-assembled cyclic peptide nanotube from the dimer-ensemble may act as the transport channel of CHCl3 molecules.

Doxorubicin-Loaded Cyclic Peptide Nanotube Bundles Overcome Chemoresistance in Breast Cancer Cells

2014 ◽  
Vol 10 (3) ◽  
pp. 445-454 ◽  
Author(s):  
Yongzhong Wang ◽  
Sijia Yi ◽  
Leming Sun ◽  
Yujian Huang ◽  
Scott C. Lenaghan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cyclic Peptide ◽  
Nanotube Bundles ◽  
Peptide Nanotube ◽  
Cyclic Peptide Nanotube

scholarly journals Energetic and Dynamic Analysis of Transport of Na+ and K+ through a Cyclic Peptide Nanotube in Water and in Lipid Bilayers

2016 ◽  
Vol 120 (46) ◽  
pp. 11912-11922 ◽  
Author(s):  
Yeonho Song ◽  
Ji Hye Lee ◽  
Hoon Hwang ◽  
George C. Schatz ◽  
Hyonseok Hwang
Keyword(s):  
Dynamic Analysis ◽  
Lipid Bilayers ◽  
Cyclic Peptide ◽  
Peptide Nanotube ◽  
Cyclic Peptide Nanotube

The effect of the diameter of cyclic peptide nanotube on its chirality discrimination

2018 ◽  
Vol 37 (3) ◽  
pp. 691-701 ◽  
Author(s):  
Hossein Farrokhpour ◽  
Alireza Mansouri ◽  
Ahmad Reza Rajabi ◽  
Alireza Najafi Chermahini
Keyword(s):  
Cyclic Peptide ◽  
Peptide Nanotube ◽  
Cyclic Peptide Nanotube

Dynamic behavior and selective adsorption of a methanol/water mixture inside a cyclic peptide nanotube

2018 ◽  
Vol 24 (7) ◽  
Author(s):  
Xialan Si ◽  
Jianfen Fan ◽  
Jian Xu ◽  
Xin Zhao ◽  
Lingling Zhang ◽  
...  
Keyword(s):  
Dynamic Behavior ◽  
Cyclic Peptide ◽  
Selective Adsorption ◽  
Water Mixture ◽  
Peptide Nanotube ◽  
Cyclic Peptide Nanotube

scholarly journals Molecular Insights on the Cyclic Peptide Nanotube-Mediated Transportation of Antitumor Drug 5-Fluorouracil

2010 ◽  
Vol 7 (6) ◽  
pp. 1985-1994 ◽  
Author(s):  
Huifang Liu ◽  
Jian Chen ◽  
Qing Shen ◽  
Wei Fu ◽  
Wei Wu
Keyword(s):  
Cyclic Peptide ◽  
Antitumor Drug ◽  
Peptide Nanotube ◽  
Cyclic Peptide Nanotube
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