Highly sensitive iridium(iii) complex-based phosphorescent probe for thiophenol detection

2017 ◽  
Vol 46 (39) ◽  
pp. 13456-13462 ◽  
Author(s):  
Li Xiong ◽  
Lin Yang ◽  
Shuai Luo ◽  
Yan Huang ◽  
Zhiyun Lu
Keyword(s):  
Rational Design ◽  
Highly Sensitive ◽  
Long Lifetime

An iridium(iii) complex could serve as a highly sensitive, long-lifetime phosphorescence thiophenol probe, obtained through rational design.

The rational design of a highly sensitive and selective fluorogenic probe for detecting nitric oxide

2014 ◽  
Vol 50 (49) ◽  
pp. 6475-6478 ◽  
Author(s):  
Sufang Ma ◽  
De-Cai Fang ◽  
Baoming Ning ◽  
Minfeng Li ◽  
Lan He ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Small Molecule ◽  
Rational Design ◽  
Switching Mechanism ◽  
Fluorogenic Probe ◽  
Highly Sensitive

A small-molecule fluorogenic probe for nitric oxide (NO) detection based on a new switching mechanism is developedviaa rational design.

scholarly journals Rational design of Au nanorods assemblies for highly sensitive and selective SERS detection of prostate specific antigen

RSC Advances ◽  
2015 ◽  
Vol 5 (48) ◽  
pp. 38354-38360 ◽  
Author(s):  
An-qi Yang ◽  
Dong Wang ◽  
Xiang Wang ◽  
Yu Han ◽  
Xue-bin Ke ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Rapid Detection ◽  
Rational Design ◽  
Specific Antigen ◽  
Early Diagnostics ◽  
Au Nanorods ◽  
Highly Sensitive ◽  
Sers Detection

A simple SERS immunosensor based on AuNRs assembly was developed for rapid detection of specific antigen in early diagnostics.

scholarly journals Protein kinase J regulates Rv0642c expression and sensitivity to rifampicin of mycobacteria

2021 ◽  
Author(s):  
Kishore Kumar Srivastava ◽  
Diwakar Kumar Singh ◽  
Sameer Tiwari ◽  
Kumari Kripalata
Keyword(s):  
Rational Design ◽  
Treatment Strategies ◽  
Host Immune System ◽  
Intracellular Growth ◽  
Methyltransferase Activity ◽  
Knock Out ◽  
Long Duration ◽  
Highly Sensitive ◽  
Novel Treatment Strategies

Mycobacterium tuberculosis (M.tb) persists for long-duration inside the human host in both active and latent form by modulating the immune response. The mechanisms employed by M.tb to survive inside the host and evade the host immune system need to be explored in greater depth for the rational design of novel treatment strategies. The phosphorylation and methylation of biomolecules need to be addressed in mycobacteria because it has an important role in infection establishment and persistence. In the present study, we elaborate on the role of PknJ in the slow growth of BCG and its association with mmaA4 protein during extracellular and intracellular growth. The pknJ knock-out (KO) BCG has been used to decode the functional significance in mycobacteria. The mmaA4 expression and methyltransferase activity is decreased in knocked-out BCG strain (pknJ-/-) during extracellular growth, while mmaA4 expression and methyltransferase activity is increased during intracellular growth of mycobacteria. The knocked-out BCG strain is highly sensitive to the rifampicin antibiotics during extracellular growth in compared to control. A significant association of pknJ and mmaA4 was found in our studies during the growth and intracellular persistence of mycobacteria.

Projected research trends in invertebrate physiology and biochemistry

1987 ◽  
Vol 65 (4) ◽  
pp. 797-802
Author(s):  
Roger G. H. Downer
Keyword(s):  
Rational Design ◽  
Research Progress ◽  
Future Research ◽  
Invertebrate Species ◽  
Research Areas ◽  
Modern Molecular Biology ◽  
Highly Sensitive ◽  
Physiology And Biochemistry ◽  
Invertebrate Physiology ◽  
Increased Activity

The direction of future research is likely to be influenced by major conceptual advances and technological breakthroughs, neither of which can be predicted with certainty. However, it is possible to identify general areas in which conceptual advances may be anticipated as a result of studies on invertebrate physiology and biochemistry and, in this regard, neurobiology and developmental biology offer particular promise. It is reasonable to predict also that the technologies of modern molecular biology and the development of highly sensitive analytical instrumentation will greatly facilitate research progress. Increased activity may also be predicted in strategic research areas including those that will lead to the rational design of pesticides and the improvement of "farming" procedures for invertebrate species that are used as sources of food. Invertebrates are also expected to continue to be used as models for biomedical research.

Rational Design of MoS2/C3N4 Hybrid Aerogel with Abundant Exposed Edges for Highly Sensitive NO2 Detection at Room Temperature

2020 ◽  
Vol 32 (17) ◽  
pp. 7215-7225
Author(s):  
Muhammad Ikram ◽  
He Lv ◽  
Zhuo Liu ◽  
Mawaz Khan ◽  
Lujia Liu ◽  
...  
Keyword(s):  
Rational Design ◽  
Room Temperature ◽  
Highly Sensitive ◽  
No2 Detection ◽  
Hybrid Aerogel

The influence of dopant concentration on temperature dependent emission spectra in LiLa1−x−yEuxTbyP4O12 nanocrystals: toward rational design of highly-sensitive luminescent nanothermometers

2016 ◽  
Vol 18 (23) ◽  
pp. 15584-15592 ◽  
Author(s):  
L. Marciniak ◽  
A. Bednarkiewicz
Keyword(s):  
Temperature Sensitivity ◽  
Rational Design ◽  
Dopant Concentration ◽  
Emission Spectra ◽  
Temperature Dependent ◽  
Sensing Range ◽  
Highly Sensitive

Luminescence nanothermometry is gaining great interest, and different excitation and readout schemes have been sought to improve temperature sensitivity and sensing range, or to simplify the readout.

scholarly journals Time-gated FRET nanoassemblies for rapid and sensitive intra- and extracellular fluorescence imaging

2016 ◽  
Vol 2 (6) ◽  
pp. e1600265 ◽  
Author(s):  
Hamid Samareh Afsari ◽  
Marcelina Cardoso Dos Santos ◽  
Stina Lindén ◽  
Ting Chen ◽  
Xue Qiu ◽  
...  
Keyword(s):  
Resonance Energy Transfer ◽  
Growth Factor Receptor ◽  
Resonance Energy ◽  
Background Fluorescence ◽  
Highly Sensitive ◽  
Unique Material ◽  
Epidermal Growth ◽  
Long Lifetime ◽  
Biomolecular Imaging ◽  
Terbium Complexes

Time-gated Förster resonance energy transfer (FRET) using the unique material combination of long-lifetime terbium complexes (Tb) and semiconductor quantum dots (QDs) provides many advantages for highly sensitive and multiplexed biosensing. Although time-gated detection can efficiently suppress sample autofluorescence and background fluorescence from directly excited FRET acceptors, Tb-to-QD FRET has rarely been exploited for biomolecular imaging. We demonstrate Tb-to-QD time-gated FRET nanoassemblies that can be applied for intra- and extracellular imaging. Immunostaining of different epitopes of the epidermal growth factor receptor (EGFR) with Tb- and QD-conjugated antibodies and nanobodies allowed for efficient Tb-to-QD FRET on A431 cell membranes. The broad usability of Tb-to-QD FRET was further demonstrated by intracellular Tb-to-QD FRET and Tb-to-QD-to-dye FRET using microinjection as well as cell-penetrating peptide–mediated endocytosis with HeLa cells. Effective brightness enhancement by FRET from several Tb to the same QD, the use of low nanomolar concentrations, and the quick and sensitive detection void of FRET acceptor background fluorescence are important advantages for advanced intra- and extracellular imaging of biomolecular interactions.

Rational design of a highly sensitive and selective “turn-on” fluorescent sensor for PO43− detection

2015 ◽  
Vol 44 (48) ◽  
pp. 20830-20833 ◽  
Author(s):  
Si-Quan Jiang ◽  
Zi-Yan Zhou ◽  
Shu-Ping Zhuo ◽  
Guo-Gang Shan ◽  
Ling-Bao Xing ◽  
...  
Keyword(s):  
Schiff Base ◽  
Rational Design ◽  
Fluorescent Sensor ◽  
Turn On ◽  
Base Unit ◽  
Highly Sensitive

An in situ-generated iron(iii) complex with a 1,8-naphthalene-based Schiff base unit has been rationally designed, which exhibits a highly selective response and excellent sensitivity for the turn-on detection of PO43− anions.

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