scholarly journals A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster

2017 ◽  
Vol 46 (38) ◽  
pp. 12785-12789 ◽  
Author(s):  
C. Lu ◽  
K. Laws ◽  
A. Eskandari ◽  
K. Suntharalingam
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Schiff Base ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Cyclooxygenase 2 ◽  
Oxygen Species

Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties,1–4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency.

A tri-metallic palladium complex with breast cancer stem cell potency

2020 ◽  
Vol 49 (14) ◽  
pp. 4211-4215
Author(s):  
Arvin Eskandari ◽  
Arunangshu Kundu ◽  
Alice Johnson ◽  
Sanjib Karmakar ◽  
Sushobhan Ghosh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Palladium Complex ◽  
Breast Cancer Stem Cell ◽  
Metallic Palladium ◽  
Micromolar Range

A multi-nuclear, triangular-shaped palladium(ii) complex is shown to equipotently kill bulk cancer cells and cancer stem cells (CSCs) in the micromolar range.

scholarly journals A reactive oxygen species-generating, cancer stem cell-potent manganese(ii) complex and its encapsulation into polymeric nanoparticles

2019 ◽  
Vol 10 (33) ◽  
pp. 7792-7800 ◽  
Author(s):  
Arvin Eskandari ◽  
Kogularamanan Suntharalingam
Keyword(s):  
Breast Cancer ◽  
Reactive Oxygen Species ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Polymeric Nanoparticles ◽  
Reactive Oxygen ◽  
Breast Cancer Stem Cell ◽  
Oxygen Species ◽  
Inflammatory Drug ◽  
Phenanthroline Complex

Here we report the breast cancer stem cell (CSC) potency of a reactive oxygen species (ROS)-generating manganese(ii)-phenanthroline complex bearing diclofenac, a nonsteriodial anti-inflammatory drug.

scholarly journals Reactive Oxygen Species in Cancer Stem Cells

2012 ◽  
Vol 16 (11) ◽  
pp. 1215-1228 ◽  
Author(s):  
Xiaoke Shi ◽  
Yan Zhang ◽  
Junheng Zheng ◽  
Jingxuan Pan
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Arif Malik ◽  
Misbah Sultana ◽  
Aamer Qazi ◽  
Mahmood Husain Qazi ◽  
Gulshan Parveen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Radiation Therapy ◽  
Cancer Stem Cells ◽  
Ionizing Radiation ◽  
Malignant Tumors ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Ros Scavenging

Cancer originates from genetic mutations accumulation. Cancer stem cells have been depicted as tumorigenic cells that can differentiate and self-renew. Cancer stem cells are thought to be resistant to conventional therapy like chemotherapy and radiation therapy. Radiation therapy and chemotherapy damage carcinomic DNA cells. Because of the ability of cancer stem cells to self-renew and reproduce malignant tumors, they are the subject of intensive research. In this review, CSCs radioresistant mechanisms which include DNA damage response and natural radiosensitizers have been summed up. Reactive oxygen species play an important role in different physiological processes. ROS scavenging is responsible for regulation of reactive oxygen species generation. A researcher has proved that microRNAs regulate tumor radiation resistance. Ionizing radiation does not kill the cancer cells; rather, IR just slows down the signs and symptoms. Ionizing radiation damages DNA directly/indirectly. IR is given mostly in combination with other chemo/radiotherapies. We briefly described here the behavior of cancer stem cells and radioresistance therapies in cancer treatment. To overcome radioresistance in treatment of cancer, strategies like fractionation modification, treatment in combination, inflammation modification, and overcoming hypoxic tumor have been practiced. Natural radiosensitizers, for example, curcumin, genistein, and quercetin, are more beneficial than synthetic compounds.

Regulation of reactive oxygen species in stem cells and cancer stem cells

2011 ◽  
Vol 227 (2) ◽  
pp. 421-430 ◽  
Author(s):  
Chiharu I. Kobayashi ◽  
Toshio Suda
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Association of reactive oxygen species levels and radioresistance in cancer stem cells

Nature ◽  
2009 ◽  
Vol 458 (7239) ◽  
pp. 780-783 ◽  
Author(s):  
Maximilian Diehn ◽  
Robert W. Cho ◽  
Neethan A. Lobo ◽  
Tomer Kalisky ◽  
Mary Jo Dorie ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Reactive Oxygen ◽  
Oxygen Species
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