Reactive Oxygen Species in Cancer Stem Cell Tumorigenesis, Metastasis, and Treatment Resistance

2021 ◽  
pp. 1-24
Author(s):  
Naomi Brook ◽  
Arun Dharmarajan
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Reactive Oxygen ◽  
Treatment Resistance ◽  
Oxygen Species

scholarly journals A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster

2017 ◽  
Vol 46 (38) ◽  
pp. 12785-12789 ◽  
Author(s):  
C. Lu ◽  
K. Laws ◽  
A. Eskandari ◽  
K. Suntharalingam
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Schiff Base ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Cyclooxygenase 2 ◽  
Oxygen Species

Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties,1–4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency.

scholarly journals A reactive oxygen species-generating, cancer stem cell-potent manganese(ii) complex and its encapsulation into polymeric nanoparticles

2019 ◽  
Vol 10 (33) ◽  
pp. 7792-7800 ◽  
Author(s):  
Arvin Eskandari ◽  
Kogularamanan Suntharalingam
Keyword(s):  
Breast Cancer ◽  
Reactive Oxygen Species ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Polymeric Nanoparticles ◽  
Reactive Oxygen ◽  
Breast Cancer Stem Cell ◽  
Oxygen Species ◽  
Inflammatory Drug ◽  
Phenanthroline Complex

Here we report the breast cancer stem cell (CSC) potency of a reactive oxygen species (ROS)-generating manganese(ii)-phenanthroline complex bearing diclofenac, a nonsteriodial anti-inflammatory drug.

scholarly journals Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics

2011 ◽  
Vol 135 (3) ◽  
pp. 293-304 ◽  
Author(s):  
Wanakee J. Carr ◽  
Rebecca E. Oberley-Deegan ◽  
Yuping Zhang ◽  
Christopher C. Oberley ◽  
Larry W. Oberley ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cell ◽  
Side Population ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Antioxidant Proteins

scholarly journals Tumor-Specific Reactive Oxygen Species Accelerators Improve Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies

2019 ◽  
Vol 20 (10) ◽  
pp. 2469 ◽  
Author(s):  
Hyeon Joo Yoo ◽  
Yibin Liu ◽  
Lei Wang ◽  
Maria-Luisa Schubert ◽  
Jean-Marc Hoffmann ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
T Cell ◽  
Tumor Microenvironment ◽  
Chimeric Antigen Receptor ◽  
Antigen Receptor ◽  
Reactive Oxygen ◽  
Treatment Resistance ◽  
Lymphocytic Leukemia ◽  
Oxygen Species ◽  
T Cell Therapy

Chimeric antigen receptor T cell (CART) therapy is currently one of the most promising treatment approaches in cancer immunotherapy. However, the immunosuppressive nature of the tumor microenvironment, in particular increased reactive oxygen species (ROS) levels, provides considerable limitations. In this study, we aimed to exploit increased ROS levels in the tumor microenvironment with prodrugs of ROS accelerators, which are specifically activated in cancer cells. Upon activation, ROS accelerators induce further generation of ROS. This leads to an accumulation of ROS in tumor cells. We hypothesized that the latter cells will be more susceptible to CARTs. CD19-specific CARTs were generated with a CD19.CAR.CD28.CD137zeta third-generation retroviral vector. Cytotoxicity was determined by chromium-51 release assay. Influence of the ROS accelerators on viability and phenotype of CARTs was determined by flow cytometry. The combination of CARTs with the ROS accelerator PipFcB significantly increased their cytotoxicity in the Burkitt lymphoma cell lines Raji and Daudi, as well as primary chronic lymphocytic leukemia cells. Exposure of CARTs to PipFcB for 48 h did not influence T cell exhaustion, viability, or T cell subpopulations. In summary, the combination of CARTs with ROS accelerators may improve adoptive immunotherapy and help to overcome tumor microenvironment-mediated treatment resistance.

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