Background:
In recent years, the emergence of stimuli-responsive nanoparticles makes drug delivery more
efficient. As an intelligent and effective targeted delivery platform, it can reduce the side effects generated during drug
transportation while enhancing the treatment efficacy. The stimuli-responsive nanoparticles can respond to different stimuli
at corresponding times and locations to deliver and release their drugs and associated therapeutic effects.
Objective:
This review aims to inform researchers on the latest advances in the application of dual-stimuli responsive
nanoparticles in precise drug delivery, with special attention to their design, drug release properties, and therapeutic effects.
Syntheses of nanoparticles with simultaneous or sequential responses to two or more stimuli (pH-redox, pH-light, redoxlight, temperature-magnetic, pH-redox-temperature, redox-enzyme-light, etc.) and the applications of such responsivity
properties for drugs control and release have become a hot topic of recent research.
Methods:
A database of relevant information for the production of this review was sourced, screened and analyzed from
Pubmed, Web of Science, SciFinder by searching for the following keywords: “dual-stimuli responsive”, “controlled
release”, “cancer therapy”, “synergistic treatment”.
Results:
Notably, the nanoparticles with dual-stimuli responsive function have an excellent control effect on drug delivery
and release, playing a crucial part in the treatment of tumors. They can improve the encapsulation and delivery efficiency
of hydrophobic chemotherapy drugs, combine chemo-photothermal therapies, apply imaging function in the diagnosis of
tumors and even conduct multi-drugs delivery to overcome multi-drugs resistance (MDR).
Conclusion:
With the development of smart dual-stimuli responsive nanoparticles, cancer treatment methods will become
more diverse and effective. All the stimuli-responsive nanoparticles functionalities exhibited their characteristics
individually within the single nanosystem.
Drug Delivery: Design of a Novel Mesoporous Organosilica Hybrid Microcarrier: a pH Stimuli-Responsive Dual-Drug-Delivery Vehicle for Intracellular Delivery of Anticancer Agents (Part. Part. Syst. Charact. 12/2013)
