Cyanopyridone flanked the tetraphenylethylene to generate an efficient, three-dimensional small molecule non-fullerene electron acceptor

2017 ◽  
Vol 1 (12) ◽  
pp. 2511-2518 ◽  
Author(s):  
Anushri Rananaware ◽  
Akhil Gupta ◽  
Gajanan Kadam ◽  
Duong Duc La ◽  
Ante Bilic ◽  
...  
Keyword(s):  
Small Molecule ◽  
Electron Acceptor ◽  
Three Dimensional

A cyanopyridone-functionalised non-fullerene acceptor (CP1). Device: ITO/P3HT : CP1 (1 : 1.2)/Ca/Al; PCE: 6.02%.

scholarly journals Patient-Derived Three-Dimensional Cortical Neurospheres to Model Parkinson′s Disease

2021 ◽  
Author(s):  
Waseem K. Raja ◽  
Esther Neves ◽  
Christopher Burke ◽  
Xin Jiang ◽  
Ping Xu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Small Molecule ◽  
Three Dimensional ◽  
Underlying Disease ◽  
Alpha Synuclein ◽  
Protein Accumulation ◽  
Molecule Inhibitor ◽  
Induced Pluripotent ◽  
Small Molecule Therapeutics

There are currently no preventive or disease-modifying therapies for Parkinson′s Disease (PD). Failures in clinical trials necessitate a re-evaluation of existing pre-clinical models in order to adopt systems that better recapitulate underlying disease mechanisms and better predict clinical outcomes. In recent years, models utilizing patient-derived induced pluripotent stem cells (iPSCs) have emerged as attractive models to recapitulate disease-relevant neuropathology in vitro without exogenous overexpression of disease-related pathologic proteins. Here, we utilized iPSCs derived from patients with early-onset PD and dementia phenotypes that harbored either a point mutation (A53T) or multiplication at the Alpha-synuclein/SNCA gene locus. We generated a three-dimensional (3D) cortical neurosphere culture model to better mimic the tissue microenvironment of the brain. We extensively characterized the differentiation process using quantitative PCR, Western immunoblotting, and immunofluorescence staining. Differentiation and aging of the neurospheres revealed alterations in fatty acid profiles and elevated total and pathogenic phospho-Alpha-synuclein levels in both A53T and the triplication lines compared to their isogenic control lines. Furthermore, treatment of the neurospheres with a small molecule inhibitor of stearoyl CoA desaturase (SCD) attenuated the protein accumulation and aberrant fatty acid profile phenotypes. Our findings suggest that the 3D cortical neurosphere model is a useful tool to interrogate targets for PD and amenable to test small molecule therapeutics.

Generating a three-dimensional non-fullerene electron acceptor by combining inexpensive spiro[fluorene-9,9′-xanthene] and cyanopyridone functionalities

2018 ◽  
Vol 2 (6) ◽  
pp. 1090-1096 ◽  
Author(s):  
Gajanan Kadam ◽  
Anuradha Anuradha ◽  
Anubha Agarwal ◽  
Avinash Puyad ◽  
Duong Duc La ◽  
...  
Keyword(s):  
Electron Acceptor ◽  
Three Dimensional

A spiro[fluorene-9,9′-xanthene]-functionalized non-fullerene acceptor A1 [D : A1 = 1 : 1.2; P3HT(D) = 5.84%, PTB7(D) = 7.21%].

An efficient, three-dimensional non-fullerene electron acceptor: functionalizing tetraphenylethylene with naphthalene diimides

2019 ◽  
Vol 3 (6) ◽  
pp. 1231-1237 ◽  
Author(s):  
Sopan M. Wagalgave ◽  
Sheshanath V. Bhosale ◽  
Rajesh S. Bhosale ◽  
Avinash L. Puyad ◽  
Jing-Yu Chen ◽  
...  
Keyword(s):  
Electron Acceptor ◽  
Three Dimensional ◽  
Naphthalene Diimide ◽  
Naphthalene Diimides

A non-fullerene acceptor, W8, based on tetraphenylethylene and naphthalene diimide ITO/PEDOT:PSS/PTB7:W8 (1 : 1.2 D : A w/w)/Ca/Al; PCE = 8.58%.

A minimal benzo[c][1,2,5]thiadiazole-based electron acceptor as a third component material for ternary polymer solar cells with efficiencies exceeding 16.0%

2020 ◽  
Vol 7 (1) ◽  
pp. 117-124 ◽  
Author(s):  
Yunlong Ma ◽  
Xiaobo Zhou ◽  
Dongdong Cai ◽  
Qisheng Tu ◽  
Wei Ma ◽  
...  
Keyword(s):  
Solar Cells ◽  
Small Molecule ◽  
Electron Acceptor ◽  
Polymer Solar Cells ◽  
Binary Blends ◽  
Component Material ◽  
Ternary Polymer

A simple small molecule of BTF is used as a third component in the binary blends of J71:ITIC and PM6:Y6 to achieve efficient ternary polymer solar cells with enhanced PCEs of 12.35% and 16.53%, respectively.

scholarly journals Design of a New Small‐Molecule Electron Acceptor Enables Efficient Polymer Solar Cells with High Fill Factor

2017 ◽  
Vol 29 (46) ◽  
pp. 1704051 ◽  
Author(s):  
Sunsun Li ◽  
Long Ye ◽  
Wenchao Zhao ◽  
Xiaoyu Liu ◽  
Jie Zhu ◽  
...  
Keyword(s):  
Solar Cells ◽  
Small Molecule ◽  
Electron Acceptor ◽  
Fill Factor ◽  
Polymer Solar Cells ◽  
High Fill Factor

A large-bandgap small-molecule electron acceptor utilizing a new indacenodibenzothiophene core for organic solar cells

2018 ◽  
Vol 2 (1) ◽  
pp. 136-142 ◽  
Author(s):  
Pengfei Wang ◽  
Haijun Fan ◽  
Cheng Zhang ◽  
Xiaozhang Zhu
Keyword(s):  
Solar Cells ◽  
Small Molecule ◽  
Electron Acceptor ◽  
Organic Solar Cells ◽  
Weak Electron

A large-bandgap molecular acceptor NIDBT utilizing a new heteroarene, indacenodibenzothiophene, featuring weak electron-donating ability, was designed and synthesized for organic solar cells.

scholarly journals Small-Molecule Labeling of Live Cell Surfaces for Three-Dimensional Super-Resolution Microscopy

2014 ◽  
Vol 136 (40) ◽  
pp. 14003-14006 ◽  
Author(s):  
Marissa K. Lee ◽  
Prabin Rai ◽  
Jarrod Williams ◽  
Robert J. Twieg ◽  
W. E. Moerner
Keyword(s):  
Small Molecule ◽  
Three Dimensional ◽  
Super Resolution ◽  
Live Cell ◽  
Cell Surfaces ◽  
Super Resolution Microscopy

scholarly journals Development of a Gas-Generation Model for the Waste Isolation Pilot Plant

1993 ◽  
Vol 333 ◽  
Author(s):  
L. H. Brush ◽  
J. W. Garner ◽  
L. J. Storz
Keyword(s):  
New Mexico ◽  
Electron Acceptor ◽  
Microbial Degradation ◽  
Pilot Plant ◽  
Three Dimensional ◽  
Cementitious Materials ◽  
Generation Model ◽  
Gas Generation ◽  
Waste Isolation Pilot Plant ◽  
Design Basis

ABSTRACTDesign-basis transuranic (TRU) waste to be emplaced in the Waste Isolation Pilot Plant (WIPP) in southeastern New Mexico may generate significant quantities of gas, which may affect the performance of the WIPP with respect to regulations for radioactive and/or chemically hazardous waste constituents. We are developing a model to predict gas generation in WIPP disposal rooms during and after filling and sealing. Currently, the model includes: (1) oxic and anoxic corrosion of steels and other Fe-base alloys, including passivation and depassivation; (2) microbial degradation of cellulosics with O2, NO3-, FeO(OH) , SO42-, or CO2as the electron acceptor; (3) α radiolysis of brine; (4) consumption of CO2and, perhaps, H2S by Ca(OH)2(in cementitious materials) and CaO (a potential backfill additive). The code simulates these processes and interactions among them by converting reactants (steels, cellulosics, etc.) to gases and other products at experimentally observed or estimated rates and plotting temporal reaction paths in three-dimensional phase diagrams for solids in the Fe-H2O-CO2-H2-H2S system.

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