Curcumin-like compounds designed to modify amyloid beta peptide aggregation patterns

RSC Advances ◽

10.1039/c7ra05300b ◽

2017 ◽

Vol 7 (50) ◽

pp. 31714-31724 ◽

Author(s):

Antonella Battisti ◽

Antonio Palumbo Piccionello ◽

Antonella Sgarbossa ◽

Silvia Vilasi ◽

Caterina Ricci ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Beta ◽

Amyloid Beta Peptide ◽

Peptide Aggregation ◽

New Concepts ◽

Novel Drugs ◽

This study suggests new concepts and potential difficulties in the design of novel drugs against diverse amyloidoses, including Alzheimer’s disease.

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P1-039: Inhibitors of amyloid beta peptide aggregation: Toward new drugs against Alzheimer's disease

Alzheimer s & Dementia ◽

10.1016/j.jalz.2015.06.235 ◽

2015 ◽

Vol 11 (7S_Part_7) ◽

pp. P352-P353 ◽

Author(s):

Olivia Berthoumieu ◽

Peter Faller ◽

Andrew J. Doig ◽

Philippe Derreumaux

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Beta ◽

New Drugs ◽

Amyloid Beta Peptide ◽

Peptide Aggregation ◽

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Xanthene Food Dye, as a Modulator of Alzheimer's Disease Amyloid-beta Peptide Aggregation and the Associated Impaired Neuronal Cell Function

PLoS ONE ◽

10.1371/journal.pone.0025752 ◽

2011 ◽

Vol 6 (10) ◽

pp. e25752 ◽

Author(s):

H. Edward Wong ◽

Inchan Kwon

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Beta ◽

Cell Function ◽

Neuronal Cell ◽

Amyloid Beta Peptide ◽

Peptide Aggregation ◽

Food Dye ◽

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A bifunctional non-natural tetrapeptide modulates amyloid-beta peptide aggregation in the presence of Cu(ii)

Metallomics ◽

10.1039/c4mt00257a ◽

2014 ◽

Vol 6 (12) ◽

pp. 2189-2192 ◽

Author(s):

Maripaz Márquez ◽

Luis M. Blancas-Mejía ◽

Adriana Campos ◽

Luis Rojas ◽

Gilberto Castañeda-Hernández ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Beta ◽

Therapeutic Potential ◽

Amyloid Beta Peptide ◽

Peptide Aggregation ◽

Beta Peptide ◽

Aβ Aggregation

A novel bifunctional non-natural tetrapeptide, Met-Asp-d-Trp-Aib, is capable of binding copper, competing with amyloid-beta peptide (Aβ) for Cu(ii), and modulating Aβ aggregation. The study of this tetrapeptide provides further insights into the role of Cu(ii) in the Aβ aggregation pathway, and into the design of compounds with therapeutic potential for Alzheimer's disease.

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Detecting bioactive amyloid beta peptide species in Alzheimer's disease

Journal of Neurochemistry ◽

10.1111/j.1471-4159.2004.02751.x ◽

2004 ◽

Vol 91 (3) ◽

pp. 648-656 ◽

Author(s):

Yuanbin Liu ◽

Richard Dargusch ◽

Cindy Banh ◽

Carol A. Miller ◽

David Schubert

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Beta ◽

Amyloid Beta Peptide ◽

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Erratum: Bapineuzumab captures the N-terminus of the Alzheimer’s disease amyloid-beta peptide in a helical conformation

Scientific Reports ◽

10.1038/srep01618 ◽

2013 ◽

Vol 3 (1) ◽

Author(s):

Luke A. Miles ◽

Gabriela A. N. Crespi ◽

Larissa Doughty ◽

Michael W. Parker

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Beta ◽

Amyloid Beta Peptide ◽

Helical Conformation ◽

Beta Peptide ◽

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Proposal for novel curcumin derivatives as potent inhibitors against Alzheimer’s disease: Ab initio molecular simulations on the specific interactions between amyloid-beta peptide and curcumin

Chemical Physics Letters ◽

10.1016/j.cplett.2017.08.024 ◽

2017 ◽

Vol 685 ◽

pp. 482-489 ◽

Author(s):

Shintaro Ota ◽

Mitsuki Fujimori ◽

Hiromi Ishimura ◽

Sergiy Shulga ◽

Noriyuki Kurita

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Ab Initio ◽

Amyloid Beta ◽

Molecular Simulations ◽

Amyloid Beta Peptide ◽

Specific Interactions ◽

Curcumin Derivatives ◽

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Effects of experimental intracerebral ventricular injection of amyloid beta peptide (1-42) aggregates on daily rhythms of Aβ-degrading enzymes in the hippocampus: Relevance to Alzheimer's disease pathophysiology

Pathophysiology ◽

10.1016/j.pathophys.2019.07.003 ◽

2019 ◽

Vol 26 (3-4) ◽

pp. 281-287

Author(s):

Andrea Castro ◽

Cinthia Coria-Lucero ◽

Ana Anzulovich ◽

Lorena Navigatore-Fonzo

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Beta ◽

Amyloid Beta Peptide ◽

Daily Rhythms ◽

Degrading Enzymes ◽

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Structure and location of amyloid beta peptide chains and arrays in Alzheimer’s disease: new findings require reevaluation of the amyloid hypothesis and of tests of the hypothesis

Neurobiology of Aging ◽

10.1016/s0197-4580(01)00283-4 ◽

2002 ◽

Vol 23 (2) ◽

pp. 225-230 ◽

Author(s):

William I Rosenblum

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Beta ◽

Amyloid Beta Peptide ◽

Amyloid Hypothesis ◽

New Findings ◽

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The extracellular matrix enriched with membrane metalloendopeptidase and insulin‐degrading enzyme suppresses the deposition of amyloid‐beta peptide in Alzheimer's disease cell models

Journal of Tissue Engineering and Regenerative Medicine ◽

10.1002/term.2906 ◽

2019 ◽

Vol 13 (10) ◽

pp. 1759-1769 ◽

Author(s):

Shumang Zhang ◽

Tongqian Xiao ◽

Yanzhen Yu ◽

Yong Qiao ◽

Zhongjuan Xu ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Extracellular Matrix ◽

Amyloid Beta ◽

Amyloid Beta Peptide ◽

Cell Models ◽

Insulin Degrading Enzyme ◽

Degrading Enzyme ◽

Beta Peptide ◽

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Why is the amyloid beta peptide of Alzheimer's disease neurotoxic?

Dalton Transactions ◽

10.1039/b718601k ◽

2008 ◽

pp. 1273 ◽

Author(s):

Arvi Rauk

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Beta ◽

Amyloid Beta Peptide ◽

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