scholarly journals Correction: Conformation dynamics of the intrinsically disordered protein c-Myb with the ff99IDPs force field

RSC Advances ◽  
2017 ◽  
Vol 7 (51) ◽  
pp. 32093-32093
Author(s):  
Xiang Guo ◽  
Jincheng Han ◽  
Ray Luo ◽  
Hai-Feng Chen
Keyword(s):  
Force Field ◽  
Protein C ◽  
Intrinsically Disordered Protein ◽  
Intrinsically Disordered ◽  
Disordered Protein

Correction for ‘Conformation dynamics of the intrinsically disordered protein c-Myb with the ff99IDPs force field’ by Xiang Guo et al., RSC Adv., 2017, 7, 29713–29721.

scholarly journals Conformation dynamics of the intrinsically disordered protein c-Myb with the ff99IDPs force field

RSC Advances ◽  
2017 ◽  
Vol 7 (47) ◽  
pp. 29713-29721 ◽  
Author(s):  
Xiang Guo ◽  
Jincheng Han ◽  
Ray Luo ◽  
Hai-Feng Chen
Keyword(s):  
Force Field ◽  
Protein C ◽  
Molten Globule ◽  
Intrinsically Disordered Protein ◽  
Intrinsically Disordered ◽  
Disordered Protein

Theff99IDPsforce field was used to reveal the conformation dynamics of c-Myb. Representative conformers of native molten globule, native pre-molten globule and native coil conformers were sampled.

scholarly journals Hydrophobic and Hydrophilic Residues are Important for Small Molecule Binding to the Intrinsically Disordered Protein c-Myc

2013 ◽  
Vol 104 (2) ◽  
pp. 52a-53a
Author(s):  
Lisette M. Fred ◽  
Kaitlyn P. Gerhart ◽  
Bethany L. Zablotsky ◽  
Scott A. Barnett ◽  
Steven J. Metallo
Keyword(s):  
Small Molecule ◽  
Protein C ◽  
Intrinsically Disordered Protein ◽  
Intrinsically Disordered ◽  
Disordered Protein ◽  
Hydrophilic Residues

Intrinsically disordered protein-specific force field CHARMM36IDPSFF

2018 ◽  
Vol 92 (4) ◽  
pp. 1722-1735 ◽  
Author(s):  
Hao Liu ◽  
Dong Song ◽  
Hui Lu ◽  
Ray Luo ◽  
Hai-Feng Chen
Keyword(s):  
Force Field ◽  
Intrinsically Disordered Protein ◽  
Specific Force ◽  
Intrinsically Disordered ◽  
Disordered Protein

scholarly journals Primary Sequence Controls the Specificity and Affinity of a Small Molecule Binding to the Intrinsically Disordered Protein c-Myc

2015 ◽  
Vol 108 (2) ◽  
pp. 389a
Author(s):  
Lisette M. Fred ◽  
Kaitlyn P. Gerhart ◽  
Bethany L. Zablotsky ◽  
Scott A. Barnett ◽  
Steven J. Metallo
Keyword(s):  
Small Molecule ◽  
Protein C ◽  
Intrinsically Disordered Protein ◽  
Primary Sequence ◽  
Intrinsically Disordered ◽  
Disordered Protein

scholarly journals Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Chen Yu ◽  
Xiaogang Niu ◽  
Fan Jin ◽  
Zhirong Liu ◽  
Changwen Jin ◽  
...  
Keyword(s):  
Protein C ◽  
Intrinsically Disordered Protein ◽  
Inhibitor Design ◽  
Intrinsically Disordered ◽  
Disordered Protein

Self-Assembling Micelles Based on an Intrinsically Disordered Protein Domain

2018 ◽  
Author(s):  
Sarah Klass ◽  
Matthew J. Smith ◽  
Tahoe Fiala ◽  
Jessica Lee ◽  
Anthony Omole ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fusion Proteins ◽  
Organic Molecules ◽  
Intrinsically Disordered Protein ◽  
Protein Domain ◽  
Enzymatic Cleavage ◽  
Intrinsically Disordered ◽  
Disordered Protein ◽  
Self Assembling ◽  
Protein Tag

Herein, we describe a new series of fusion proteins that have been developed to self-assemble spontaneously into stable micelles that are 27 nm in diameter after enzymatic cleavage of a solubilizing protein tag. The sequences of the proteins are based on a human intrinsically disordered protein, which has been appended with a hydrophobic segment. The micelles were found to form across a broad range of pH, ionic strength, and temperature conditions, with critical micelle concentration (CMC) values below 1 µM being observed in some cases. The reported micelles were found to solubilize hydrophobic metal complexes and organic molecules, suggesting their potential suitability for catalysis and drug delivery applications.

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